ITF-2357 (Givinostat) Hydrochloride Monohydrate Solubility in DMSO

In Vitro Solubility

Batch:

All in vitro solubility values are batch-tested experimental data (non-literature values).

Solvent	Solubility & Note
DMSO	95 mg/mL (199.59 mM) (Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water	Insoluble
Ethanol	Insoluble
DMSO	95 mg/mL (199.59 mM) (Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol	3 mg/mL
Water	Insoluble
DMSO	95 mg/mL (199.59 mM) (Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol	1 mg/mL
Water	Insoluble
DMSO	95 mg/mL (199.59 mM) (Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol	6 mg/mL
Water	Insoluble
DMSO	95 mg/mL (199.59 mM) (Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water	Insoluble
Ethanol	Insoluble

FAQ

Q: Why does a DMSO stock precipitate in media/saline?

A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.

How to fix it?

Preheat media/saline to 37°C.
Mix rapidly (pipette/vortex) upon addition.
For complex mixes, always add the aqueous phase last.
Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Check the ITF-2357 (Givinostat) Hydrochloride Monohydrate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

How to Prepare Stock Solution?

Concentration Volume Mass

Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.

Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.

Formulation for Animal Experiments

Batch:

Administration Route	Formulation Type	Formulation Details	Solubility	Preparation Method
Oral Administration	Homogeneous suspension	CMC-NA	≥5mg/mL	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Injection	Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	5.000mg/mL (10.50mM)	Taking the 1 mL working solution as an example, add 50 μL of 100 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 0 μL of Tween80 to the above system, mix evenly to make it clear; then continue to add 550 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Oral Administration	Homogeneous suspension	CMC-NA	≥5mg/mL	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Oral Administration	Homogeneous suspension	CMC-NA	≥5mg/mL	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Oral Administration	Homogeneous suspension	CMC-NA	≥5mg/mL	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Oral Administration	Homogeneous suspension	CMC-NA	≥5mg/mL	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

Recommended and Maximum Dosing Volumes for Animal Experiments

Other Animals:

Size	Price	Qty
5mg	USD 170
1g	USD 2,990

ITF-2357 (Givinostat) Hydrochloride Monohydrate Solubility

In Vitro Solubility

How to Prepare Stock Solution?

Formulation for Animal Experiments

Recommended and Maximum Dosing Volumes for Animal Experiments

In Vivo Formulation Calculator

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