CAS No. 732302-99-7
Batch:
Purity:99.77
Chemical Structure
Check the
ITF-2357 (Givinostat) Hydrochloride Monohydrate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | [6-(diethylaminomethyl)naphthalen-2-yl]methyl N-[4-(hydroxycarbamoyl)phenyl]carbamate;hydrate;hydrochloride | |
|---|---|---|
| CAS Number | 732302-99-7 | |
| Molecular Formula |
C24H27N3O4.HCl.H2O |
|
| Molecular Weight (MW) | 475.97 | |
| SMILES | CCN(CC)CC1=CC2=C(C=C1)C=C(C=C2)COC(=O)NC3=CC=C(C=C3)C(=O)NO.O.Cl | |
| InChIKey | FKGKZBBDJSKCIS-UHFFFAOYSA-N |
Givinostat (ITF-2357) is an orally active histone deacetylase (HDAC) inhibitor targeting class I and class II HDACs. HDAC inhibition alters gene transcription and attenuates downstream inflammatory signaling pathways. In peripheral blood mononuclear cells, Givinostat suppresses the production of pro-inflammatory cytokines, including TNF-α, IL-1β, IL-6, and IFN-γ. Additionally, treatment inhibits total intracellular IL-1β synthesis at concentrations below 25 nM and promotes apoptotic cell death in hematological cells. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
95 mg/mL
(199.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
95 mg/mL
(199.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
| DMSO |
95 mg/mL
(199.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 1 mg/mL |
| Water | Insoluble |
| DMSO |
95 mg/mL
(199.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 6 mg/mL |
| Water | Insoluble |
| DMSO |
95 mg/mL
(199.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- ITF-2357 (Givinostat) Hydrochloride Monohydrate Mechanism of Action: HDAC Inhibition in Skeletal Muscle Cell Research
- ITF-2357 (Givinostat) Hydrochloride Monohydrate Clinical Trials
- ITF-2357 (Givinostat) Hydrochloride Monohydrate Working Concentration | Cell Culture | Treatment
- ITF-2357 (Givinostat) Hydrochloride Monohydrate Solubility in DMSO
- ITF-2357 (Givinostat) Hydrochloride Monohydrate Stock Solution
- ITF-2357 (Givinostat) Hydrochloride Monohydrate Storage
- ITF-2357 (Givinostat) Hydrochloride Monohydrate Stability
- ITF-2357 (Givinostat) Hydrochloride Monohydrate Combination Database
- ITF-2357 (Givinostat) Hydrochloride Monohydrate Molecular Weight
- ITF-2357 (Givinostat) Hydrochloride Monohydrate SMILES
- ITF-2357 (Givinostat) Hydrochloride Monohydrate Chemical Structure (2D and 3D)
- ITF-2357 (Givinostat) Hydrochloride Monohydrate IC50 for Cell-based and Cell-free Assays
- ITF-2357 (Givinostat) Hydrochloride Monohydrate APExBIO (A4093)? Try a better option.
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- ITF-2357 (Givinostat) Hydrochloride Monohydrate Sigma (SML1772)? Try a better option.
- ITF-2357 (Givinostat) Hydrochloride Monohydrate SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.