|
MOLM-14
|
9.18 nM
|
MTS assay, calculated by nonlinear regression in GraphPad Prism 10, fitting normalized cell viability to four-parameter dose-response curves.
|
Download PDF
|
|
MONOMAC-1
|
18.84 nM
|
MTS assay, calculated by nonlinear regression in GraphPad Prism 10, fitting normalized cell viability to four-parameter dose-response curves.
|
Download PDF
|
|
Ba/F3 PT IL-3+
|
1.1 nM
|
CCK-8 cell viability assay
|
Download PDF
|
|
Ba/F3 G1202R mutant
|
107.1 nM
|
CCK-8 cell viability assay
|
Download PDF
|
|
Ba/F3 I1171N mutant
|
0.9 nM
|
CCK-8 cell viability assay
|
Download PDF
|
|
Ba/F3 I1171N+ E1210K mutant
|
165.4 nM
|
CCK-8 cell viability assay
|
Download PDF
|
|
Ba/F3 I1171N+ D1203N mutant
|
261.9 nM
|
CCK-8 cell viability assay
|
Download PDF
|
|
Ba/F3 I1171N+ E1129V mutant
|
68.9 nM
|
CCK-8 cell viability assay
|
Download PDF
|
|
Primary human FLT3ITD AML cells
|
0.5-0.6 nM
|
Proliferation assay
|
PMC8864657
|
|
MV4-11
|
3.02 nM
|
CCK-8 assay
|
Download PDF
|
|
FLT3
|
1–2 nM
|
cell-based assays
|
PMC5572576
|
|
MOLM-14-MR cells
|
29.08 to 49.31 nM
|
2.0 Assay
|
Download PDF
|
|
MOLM-14-MR2 cells
|
29.08 to 49.31 nM
|
2.0 Assay
|
Download PDF
|
|
MV4-11
|
0.92 nM
|
CellTiter-Glo® Luminescent Cell Viability Assay
|
Download PDF
|
|
MOLM-13
|
2.9 nM
|
CellTiter-Glo® Luminescent Cell Viability Assay
|
Download PDF
|
|
Ba/F3 FLT3-ITD
|
1.8 nM
|
Cell viability assay
|
Download PDF
|
|
Ba/F3 FLT3-D835Y
|
1.6 nM
|
Cell viability assay
|
Download PDF
|
|
Ba/F3 FLT3-ITD-D835Y
|
2.1 nM
|
Cell viability assay
|
Download PDF
|
|
Ba/F3 FLT3-ITD-F691L
|
22 nM
|
Cell viability assay
|
Download PDF
|
|
Ba/F3 FLT3-ITD-F691I
|
49 nM
|
Cell viability assay
|
Download PDF
|
|
Parental Ba/F3
|
420 nM
|
Cell viability assay
|
Download PDF
|
|
MOLM-13
|
0.99 ± 0.14 nM
|
MTS assay, fluorescence plate reader, nonlinear best-fit regression analysis using Prism 8 software
|
Download PDF
|
|
MOLM-14
|
3.60 ± 0.04 nM
|
MTS assay, fluorescence plate reader, nonlinear best-fit regression analysis using Prism 8 software
|
Download PDF
|
|
MV4-11
|
1.85 ± 0.06 nM
|
MTS assay, fluorescence plate reader, nonlinear best-fit regression analysis using Prism 8 software
|
Download PDF
|
|
MV4-11, MOLM13, THP1, HL60, U937, OCI-AML2, OCI-AML3
|
MV4-11: 1.989 nM, MOLM13: 3.011 nM, THP1: --, HL60: --, U937
|
CellTiter-Glo® 2.0 Cell Viability Assay, luminescence measurement, GraphPad Prism for determination
|
Download PDF
|
|
MOLM-13, MV4-11
|
MV4-11 + FL: 6.76 nM, MV4-11 + FGF2: 8.06 nM, MOLM13 + FL: 1
|
CellTiter-Glo® 2.0 Cell Viability Assay, luminescence measurement, GraphPad Prism for determination
|
Download PDF
|
|
Ba/F3 FLT3-ITD
|
4.5 nM
|
CellTiter-Glo® 2.0 Assay and Sigmoid-Emax model nonlinear regression analysis
|
PMC11974573
|
|
Ba/F3 FLT3-JMD D835V
|
0.60 nM
|
CellTiter-Glo® 2.0 Assay and Sigmoid-Emax model nonlinear regression analysis
|
PMC11974573
|
|
Ba/F3 FLT3-TKD D835E
|
0.96 nM
|
CellTiter-Glo® 2.0 Assay and Sigmoid-Emax model nonlinear regression analysis
|
PMC11974573
|
|
Ba/F3 FLT3-TKD D835A
|
0.97 nM
|
CellTiter-Glo® 2.0 Assay and Sigmoid-Emax model nonlinear regression analysis
|
PMC11974573
|
|
Ba/F3 FLT3-TKD D835N
|
1.0 nM
|
CellTiter-Glo® 2.0 Assay and Sigmoid-Emax model nonlinear regression analysis
|
PMC11974573
|
|
Ba/F3 FLT3-TKD D835G
|
1.4 nM
|
CellTiter-Glo® 2.0 Assay and Sigmoid-Emax model nonlinear regression analysis
|
PMC11974573
|
|
Ba/F3 FLT3-TKD D835L+K
|
2.6 nM
|
CellTiter-Glo® 2.0 Assay and Sigmoid-Emax model nonlinear regression analysis
|
PMC11974573
|
|
Ba/F3 FLT3-TKD D835del
|
0.87 nM
|
CellTiter-Glo® 2.0 Assay and Sigmoid-Emax model nonlinear regression analysis
|
PMC11974573
|
|
Ba/F3 FLT3-TKD I836del
|
3.5 nM
|
CellTiter-Glo® 2.0 Assay and Sigmoid-Emax model nonlinear regression analysis
|
PMC11974573
|
|
Ba/F3 FLT3-TKD I836L+D
|
1.7 nM
|
CellTiter-Glo® 2.0 Assay and Sigmoid-Emax model nonlinear regression analysis
|
PMC11974573
|
|
Ba/F3 FLT3-TKD I836S
|
4.0 nM
|
CellTiter-Glo® 2.0 Assay and Sigmoid-Emax model nonlinear regression analysis
|
PMC11974573
|
|
Ba/F3 FLT3-TKD I836T
|
3.9 nM
|
CellTiter-Glo® 2.0 Assay and Sigmoid-Emax model nonlinear regression analysis
|
PMC11974573
|
|
Ba/F3 FLT3-TKD N841Y
|
0.85 nM
|
CellTiter-Glo® 2.0 Assay and Sigmoid-Emax model nonlinear regression analysis
|
PMC11974573
|
|
Ba/F3 FLT3-TKD R845S
|
4.8 nM
|
CellTiter-Glo® 2.0 Assay and Sigmoid-Emax model nonlinear regression analysis
|
PMC11974573
|
|
Ba/F3 FLT3-TKD N676K
|
0.99 nM
|
CellTiter-Glo® 2.0 Assay and Sigmoid-Emax model nonlinear regression analysis
|
PMC11974573
|
|
Ba/F3 FLT3-JMD Y572C
|
1.1 nM
|
CellTiter-Glo® 2.0 Assay and Sigmoid-Emax model nonlinear regression analysis
|
PMC11974573
|
|
Ba/F3 FLT3-JMD F590G/Y591D
|
5.0 nM
|
CellTiter-Glo® 2.0 Assay and Sigmoid-Emax model nonlinear regression analysis
|
PMC11974573
|
|
Ba/F3 FLT3-JMD F590 D593delinsLY
|
4.9 nM
|
CellTiter-Glo® 2.0 Assay and Sigmoid-Emax model nonlinear regression analysis
|
PMC11974573
|
|
Ba/F3 FLT3-JMD V592G
|
4.8 nM
|
CellTiter-Glo® 2.0 Assay and Sigmoid-Emax model nonlinear regression analysis
|
PMC11974573
|
|
Ba/F3 FLT3-JMD V592A
|
8.6 nM
|
CellTiter-Glo® 2.0 Assay and Sigmoid-Emax model nonlinear regression analysis
|
PMC11974573
|
|
Ba/F3 FLT3-JMD D593del
|
5.8 nM
|
CellTiter-Glo® 2.0 Assay and Sigmoid-Emax model nonlinear regression analysis
|
PMC11974573
|
|
Ba/F3 FLT3-JMD F594L
|
5.5 nM
|
CellTiter-Glo® 2.0 Assay and Sigmoid-Emax model nonlinear regression analysis
|
PMC11974573
|
|
Ba/F3 FLT3-JMD V579A
|
2.5 nM
|
CellTiter-Glo® 2.0 Assay and Sigmoid-Emax model nonlinear regression analysis
|
PMC11974573
|
|
Ba/F3 FLT3-JMD E598/Y599del
|
1.0 nM
|
CellTiter-Glo® 2.0 Assay and Sigmoid-Emax model nonlinear regression analysis
|
PMC11974573
|
|
Ba/F3 FLT3-TKD K663R
|
1.5 nM
|
CellTiter-Glo® 2.0 Assay and Sigmoid-Emax model nonlinear regression analysis
|
PMC11974573
|
|
Ba/F3 FLT3-TKD K663Q
|
0.98 nM
|
CellTiter-Glo® 2.0 Assay and Sigmoid-Emax model nonlinear regression analysis
|
PMC11974573
|
|
Ba/F3 FLT3-TKD R834Q
|
2.4 nM
|
CellTiter-Glo® 2.0 Assay and Sigmoid-Emax model nonlinear regression analysis
|
PMC11974573
|
|
Ba/F3 FLT3-TKD D839G
|
0.56 nM
|
CellTiter-Glo® 2.0 Assay and Sigmoid-Emax model nonlinear regression analysis
|
PMC11974573
|
|
Ba/F3 FLT3-TKD S840insGS
|
1.2 nM
|
CellTiter-Glo® 2.0 Assay and Sigmoid-Emax model nonlinear regression analysis
|
PMC11974573
|
|
Ba/F3 FLT3-TKD N841I
|
0.77 nM
|
CellTiter-Glo® 2.0 Assay and Sigmoid-Emax model nonlinear regression analysis
|
PMC11974573
|
|
Ba/F3 FLT3-TKD Y842C
|
1.4 nM
|
CellTiter-Glo® 2.0 Assay and Sigmoid-Emax model nonlinear regression analysis
|
PMC11974573
|
|
Ba/F3 FLT3-TKD I867S
|
1.8 nM
|
CellTiter-Glo® 2.0 Assay and Sigmoid-Emax model nonlinear regression analysis
|
PMC11974573
|
|
Ba/F3 (EML4-ALK I1171T)
|
4.17 nM
|
Cell viability assay (assay)
|
Download PDF
|
|
Ba/F3 (EML4-ALK I1171N)
|
6.13 nM
|
Cell viability assay (assay)
|
Download PDF
|
|
Ba/F3 (EML4-ALK I1171S)
|
2.86 nM
|
Cell viability assay (assay)
|
Download PDF
|
|
Ba/F3 (EML4-ALK V1180L)
|
1.45 nM
|
Cell viability assay (assay)
|
Download PDF
|
|
Ba/F3 (EML4-ALK L1196M)
|
20.4 nM
|
Cell viability assay (assay)
|
Download PDF
|
|
Ba/F3 (EML4-ALK G1202R)
|
168 nM
|
Cell viability assay (assay)
|
Download PDF
|
|
Ba/F3 (EML4-ALK C1156Y)
|
0.66 nM
|
Cell viability assay (assay)
|
Download PDF
|
|
Ba/F3 (EML4-ALK F1174V)
|
3.41 nM
|
Cell viability assay (assay)
|
Download PDF
|
|
Ba/F3 (EML4-ALK F1245V)
|
1.41 nM
|
Cell viability assay (assay)
|
Download PDF
|
|
Ba/F3 (EML4-ALK G1269A)
|
1.39 nM
|
Cell viability assay (assay)
|
Download PDF
|
|
Ba/F3 (EML4-ALK T1151K)
|
1.24 nM
|
Cell viability assay (assay)
|
Download PDF
|
|
Ba/F3 (EML4-ALK F1174I)
|
4.72 nM
|
Cell viability assay (assay)
|
Download PDF
|
|
Ba/F3 (EML4-ALK L1196Q)
|
25.5 nM
|
Cell viability assay (assay)
|
Download PDF
|
|
Ba/F3 (EML4-ALK D1203N)
|
53.0 nM
|
Cell viability assay (assay)
|
Download PDF
|
|
Ba/F3 (EML4-ALK L1256F)
|
0.34 nM
|
Cell viability assay (assay)
|
Download PDF
|
|
Ba/F3 (ALK I1171S +G1269A)
|
13.3 nM
|
Cell viability assay (assay)
|
Download PDF
|
|
Ba/F3 (I1171S)
|
2.86 nM
|
Cell viability assay (assay)
|
Download PDF
|
|
Ba/F3 (I1171N +F1174I)
|
23.5 nM
|
Cell viability assay (assay)
|
Download PDF
|
|
Ba/F3 (I1171N +F1174L)
|
3.15 nM
|
Cell viability assay (assay)
|
Download PDF
|
|
Ba/F3 (I1171N +L1196M)
|
14.0 nM
|
Cell viability assay (assay)
|
Download PDF
|
|
Ba/F3 (I1171N +L1198F)
|
1.64 nM
|
Cell viability assay (assay)
|
Download PDF
|
|
Ba/F3 (I1171N +L1198H)
|
6.95 nM
|
Cell viability assay (assay)
|
Download PDF
|
|
Ba/F3 (I1171N +L1256F)
|
0.41 nM
|
Cell viability assay (assay)
|
Download PDF
|
|
Ba/F3 (I1171N +G1269A)
|
11.4 nM
|
Cell viability assay (assay)
|
Download PDF
|
|
Ba/F3 (G1202R +L1196M)
|
117 nM
|
Cell viability assay (assay)
|
Download PDF
|
|
Ba/F3 (D1203N +F1245V)
|
64 nM
|
Cell viability assay (assay)
|
Download PDF
|
|
Ba/F3 (D1203N +L1196M)
|
109 nM
|
Cell viability assay (assay)
|
Download PDF
|
|
Ba/F3 (L1198F-mutant EML4-ALK)
|
0.1 nM
|
Cell viability assay (assay)
|
Download PDF
|
|
Ba/F3 (WT EML4-ALK)
|
0.78 nM
|
Cell viability assay (assay)
|
Download PDF
|
|
Ba/F3 (L1198F +G1202R)
|
32 nM
|
Cell viability assay (assay)
|
Download PDF
|
|
Ba/F3 (G1202R)
|
168 nM
|
Cell viability assay (assay)
|
Download PDF
|
|
Ba/F3 (I1171N +L1198F)
|
1.6 nM
|
Cell viability assay (assay)
|
Download PDF
|
|
Ba/F3 (I1171N)
|
6.1 nM
|
Cell viability assay (assay)
|
Download PDF
|
|
AXL overexpressed H3122
|
<5 nM
|
Cell viability assay
|
Download PDF
|
|
KM12
|
<30 nM
|
Cell viability assay
|
Download PDF
|
|
Ba/F3 (TPM3-NTRK1 WT)
|
13.3 nM
|
Cell viability assay
|
Download PDF
|
|
Ba/F3 (TPM3-NTRK1 G667C)
|
12.7 nM
|
Cell viability assay
|
Download PDF
|
