CAS No. 1254053-43-4
Batch:
Purity:99.83
Chemical Structure
Check the
ASP2215 (Gilteritinib)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 6-ethyl-3-[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]anilino]-5-(oxan-4-ylamino)pyrazine-2-carboxamide | |
|---|---|---|
| CAS Number | 1254053-43-4 | |
| Molecular Formula |
C29H44N8O3 |
|
| Molecular Weight (MW) | 552.71 | |
| SMILES | CCC1=C(N=C(C(=N1)C(=O)N)NC2=CC(=C(C=C2)N3CCC(CC3)N4CCN(CC4)C)OC)NC5CCOCC5 | |
| InChIKey | GYQYAJJFPNQOOW-UHFFFAOYSA-N |
Biological Activity
Gilteritinib (ASP2215) is a small-molecule inhibitor of FLT3 and AXL, exhibiting approximately 800-fold higher potency for FLT3 over c-KIT. By selectively blocking receptor tyrosine kinase activity, gilteritinib suppresses downstream STAT5, AKT, and ERK signaling pathways, thereby inhibiting cell proliferation and inducing apoptosis in acute myeloid leukemia models.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
4 mg/mL
(7.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
5 mg/mL
(9.04 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | 4 mg/mL |
| Water | Insoluble |
| Ethanol | 11 mg/mL |
| DMSO |
4 mg/mL
(7.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| DMSO |
10 mg/mL
(18.09 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 6 mg/mL |
| Water | ˂1 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Jump to
- ASP2215 (Gilteritinib) Mechanism of Action: FLT3 Inhibition in Leukemic Blast Cells Research
- ASP2215 (Gilteritinib) Clinical Trials
- ASP2215 (Gilteritinib) Working Concentration | Cell Culture | Treatment
- ASP2215 (Gilteritinib) Solubility in DMSO
- ASP2215 (Gilteritinib) Stock Solution
- ASP2215 (Gilteritinib) Storage
- ASP2215 (Gilteritinib) Stability
- ASP2215 (Gilteritinib) Combination Database
- ASP2215 (Gilteritinib) Molecular Weight
- ASP2215 (Gilteritinib) SMILES
- ASP2215 (Gilteritinib) Chemical Structure (2D and 3D)
- ASP2215 (Gilteritinib) IC50 for Cell-based and Cell-free Assays
- ASP2215 (Gilteritinib) Sigma (AMBH324AB971)? Try a better option.
- ASP2215 (Gilteritinib) MedChemExpress (HY-12432)? Try a better option.
- ASP2215 (Gilteritinib) Cayman (21503)? Try a better option.
- ASP2215 (Gilteritinib) APExBIO (A4691)? Try a better option.
- ASP2215 (Gilteritinib) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.