CAS No. 491833-30-8

Batch: Purity:99.87
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Genz-123346 free base Chemical Structure
Chemical Structure
Check the Genz-123346 free base product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[(1R,2R)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-hydroxy-3-pyrrolidin-1-ylpropan-2-yl]nonanamide
CAS Number 491833-30-8
Molecular Formula

C24H38N2O4
Molecular Weight (MW) 418.57
SMILES CCCCCCCCC(=O)NC(CN1CCCC1)C(C2=CC3=C(C=C2)OCCO3)O
InChIKey JMNXWOFCUJJYEO-HYBUGGRVSA-N

Ordering Information

Biological Activity

Genz-123346 is a potent inhibitor of glucosylceramide synthase (GL1 synthase) that blocks the conversion of ceramide to glucosylceramide. By inhibiting GL1 synthase, Genz-123346 disrupts the primary rate-limiting step in glycosphingolipid biosynthesis, leading to depleted cellular glucosylceramide levels and diminished downstream ganglioside production. Consequently, this compound modulates glycosphingolipid metabolism, improves insulin sensitivity, and suppresses renal cyst growth in polycystic kidney disease models. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 84 mg/mL (200.68 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 84 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.