CAS No. 1403-66-3

Batch: Purity:99
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Gentamicin Chemical Structure
Chemical Structure
Check the Gentamicin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[4,6-diamino-3-[3-amino-6-[1-(methylamino)ethyl]oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol
CAS Number 1403-66-3
Molecular Formula

C60H123N15O21
Molecular Weight (MW) 1390.71
SMILES CNC(C)C1CCC(N)C(O1)OC2C(N)CC(N)C(OC3OCC(C)(O)C(NC)C3O)C2O.CNC4C(O)C(OCC4(C)O)OC5C(N)CC(N)C(OC6OC(CN)CCC6N)C5O.CNC7C(O)C(OCC7(C)O)OC8C(N)CC(N)C(OC9OC(CCC9N)C(C)N)C8O
InChIKey CEAZRRDELHUEMR-UHFFFAOYSA-N

Ordering Information

Biological Activity

Gentamicin is an aminoglycoside antibiotic that targets the 30S ribosomal subunit by binding specifically to 16S rRNA. This binding disrupts protein translation and fidelity, leading to bacterial cell death, particularly in Gram-negative infections. In addition to its bactericidal properties, gentamicin induces acute kidney injury and renal impairment in vivo, making it a standard agent for establishing animal models of acute renal failure. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 100 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.