Target Selectivity of Gefitinib (ZD1839)
| Key Target | IC50 | Description | Reference |
|---|---|---|---|
| EGFR | 0.5 nM | in vitro EGFR kinase assays | PMC6491395 |
| EGFR | 2.12 nM | cell-free assays | PMC9520547 |
| VEGFR-2 | 45.3 nM | VEGFR-2 kinase assay (using recombinant human VEGFR-2/KDR ELISA kit) | PMC9415638 |
| EGFR2 | 1.2 µM | -- | PMC10713255 |
| Raf | 10 µM | -- | PMC10713255 |
| MEK-1 | 10 µM | -- | PMC10713255 |
| ERK-2 | 100 µM | -- | PMC10713255 |
Check the
Gefitinib (ZD1839)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
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- Gefitinib (ZD1839) Mechanism of Action: EGFR Inhibition in Non-Small Cell Lung Cancer Cells Research
- Gefitinib (ZD1839) Clinical Trials
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- Gefitinib (ZD1839) Combination Database
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- Gefitinib (ZD1839) Chemical Structure (2D and 3D)
- Gefitinib (ZD1839) IC50 for Cell-based and Cell-free Assays
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- Gefitinib (ZD1839) SDS｜MSDS