CAS No. 873652-48-3

Batch: Purity:99.73
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GDC-0152 Chemical Structure
Chemical Structure
Check the GDC-0152 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2S)-1-[(2S)-2-cyclohexyl-2-[[(2S)-2-(methylamino)propanoyl]amino]acetyl]-N-(4-phenylthiadiazol-5-yl)pyrrolidine-2-carboxamide
CAS Number 873652-48-3
Molecular Formula

C25H34N6O3S
Molecular Weight (MW) 498.64
SMILES CC(C(=O)NC(C1CCCCC1)C(=O)N2CCCC2C(=O)NC3=C(N=NS3)C4=CC=CC=C4)NC
InChIKey WZRFLSDVFPIXOV-LRQRDZAKSA-N

Ordering Information

Biological Activity

GDC-0152 is a synthetic small-molecule antagonist of inhibitor of apoptosis proteins (IAPs) that binds to XIAP-BIR3 (Ki = 28 nM), ML-IAP-BIR3 (Ki = 14 nM), cIAP1-BIR3 (Ki = 17 nM), and cIAP2-BIR3 (Ki = 43 nM). By inhibiting IAP family proteins, GDC-0152 promotes cIAP1 and cIAP2 degradation, activates caspase cascades, modulates NF-kB signaling, and induces apoptosis in cancer cell lines. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 99 mg/mL (198.54 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 99 mg/mL
Water 3 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.