CAS No. 1446321-46-5
Batch:
Purity:99.96
Chemical Structure
Check the
Voxelotor
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 2-hydroxy-6-[[2-(2-propan-2-ylpyrazol-3-yl)-3-pyridinyl]methoxy]benzaldehyde | |
|---|---|---|
| CAS Number | 1446321-46-5 | |
| Molecular Formula |
C19H19N3O3 |
|
| Molecular Weight (MW) | 337.37 | |
| SMILES | CC(C)N1C(=CC=N1)C2=C(C=CC=N2)COC3=CC=CC(=C3C=O)O | |
| InChIKey | FWCVZAQENIZVMY-UHFFFAOYSA-N |
Biological Activity
Voxelotor is a novel, orally active hemoglobin S (HbS) modifier that increases hemoglobin oxygen affinity. By binding to the N-terminal alpha-chain of hemoglobin, it stabilizes the oxygenated hemoglobin conformation and directly inhibits hypoxia-induced HbS polymerization. Consequently, voxelotor reduces red blood cell sickling, improves erythrocyte deformability, and prevents membrane damage and hemolysis, offering protective cellular effects against sickle cell disease pathology. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
67 mg/mL
(198.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
| DMSO |
67 mg/mL
(198.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 10 mg/mL |
| Water | Insoluble |
| DMSO |
67 mg/mL
(198.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 67 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
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Note: Technical data last updated: Sep 1, 2026.