CAS No. 173932-75-7
Batch:
Purity:99.94
Chemical Structure
Check the
Gambogenic acid
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (Z)-4-[(1S,2S,13S,15R)-7-[(2E)-3,7-dimethylocta-2,6-dienyl]-6,8-dihydroxy-17,17-dimethyl-5-(3-methylbut-2-enyl)-10,14-dioxo-3,16-dioxapentacyclo[11.4.1.02,11.02,15.04,9]octadeca-4,6,8,11-tetraen-15-yl]-2-methylbut-2-enoic acid | |
|---|---|---|
| CAS Number | 173932-75-7 | |
| Molecular Formula |
C38H46O8 |
|
| Molecular Weight (MW) | 630.77 | |
| InChIKey | RCWNBHCZYXWDOV-VSFMGBBVSA-N |
Biological Activity
Gambogenic acid is a natural small-molecule inhibitor of the FGFR signaling pathway and enhancer of zeste homolog 2 (EZH2). By covalently binding to Cys668 within the EZH2-SET domain, it triggers EZH2 ubiquitination and protein degradation. This targeted inhibition suppresses downstream oncogenic signaling, inhibiting cell proliferation and inducing apoptosis in non-small-cell lung cancer cells. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
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Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(158.53 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.