CAS No. 851983-85-2
| IUPAC Name | (3S,8R,9S,10R,13S,14S)-17-(benzimidazol-1-yl)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-ol | |
|---|---|---|
| CAS Number | 851983-85-2 | |
| Molecular Formula |
C26H32N2O |
|
| Molecular Weight (MW) | 388.55 | |
| SMILES | CC12CCC(CC1=CCC3C2CCC4(C3CC=C4N5C=NC6=CC=CC=C65)C)O | |
| InChIKey | PAFKTGFSEFKSQG-PAASFTFBSA-N |
Galeterone (TOK-001) is a selective CYP17 inhibitor (IC50 300 nM) and androgen receptor (AR) antagonist. It disrupts androgen receptor signaling through inhibition of CYP17 activity, competitive antagonism of AR, and downregulation of AR protein expression. Consequently, galeterone inhibits AR-mediated transcription, suppresses prostate cancer cell proliferation, and induces endoplasmic reticulum stress-mediated apoptosis in prostate cancer cell models. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| Ethanol | 40 mg/mL |
| DMSO |
24 mg/mL
(61.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | 40 mg/mL |
| DMSO |
39 mg/mL
(100.37 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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