CAS No. 1426138-42-2

Batch: Purity:99.75
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FX1 Chemical Structure
Chemical Structure
Check the FX1 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 3-[5-(5-chloro-2-oxoindol-3-yl)-4-hydroxy-2-sulfanylidene-1,3-thiazol-3-yl]propanoic acid
CAS Number 1426138-42-2
Molecular Formula

C14H9ClN2O4S2
Molecular Weight (MW) 368.82
SMILES C1=CC2=NC(=O)C(=C2C=C1Cl)C3=C(N(C(=S)S3)CCC(=O)O)O
InChIKey JYBGCTWNOMSQJY-UHFFFAOYSA-N

Ordering Information

Biological Activity

FX1 is a selective inhibitor targeting the BTB domain of B-cell lymphoma 6 (BCL6). By disrupting the interaction between BCL6 and its corepressor proteins, FX1 derepresses transcriptional repression, alters target gene expression, and potently induces apoptosis in diffuse large B-cell lymphoma cells. Furthermore, FX1 displays high selectivity for BCL6 over other non-target protein kinases. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 20 mg/mL (54.22 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.