CAS No. 41733-55-5
Batch:
Purity:99.96
Chemical Structure
Check the
Furosemide sodium
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | sodium 4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoylbenzoate | |
|---|---|---|
| CAS Number | 41733-55-5 | |
| Molecular Formula |
C12H10ClN2NaO5S |
|
| Molecular Weight (MW) | 352.73 | |
| SMILES | [Na+].N[S](=O)(=O)C1=C(Cl)C=C(NCC2=CC=CO2)C(=C1)C([O-])=O | |
| InChIKey | DLFCAVBMDSKMEY-UHFFFAOYSA-M |
Biological Activity
Furosemide sodium is a potent, orally active inhibitor of the Na-K-Cl cotransporter (NKCC) and a subtype-selective antagonist of the GABAA receptor. By inhibiting NKCC-mediated ion transport and modulating GABAA receptor signaling, furosemide sodium alters transmembrane electrolyte flux and neuronal excitability, leading to reduced ion reabsorption and suppressed GABA-gated currents in targeted cell populations. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
71 mg/mL
(201.28 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 71 mg/mL |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.