CAS No. 129453-61-8
Batch:
Purity:99.97
Chemical Structure
Check the
Fulvestrant (ICI-182780)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (7R,8R,9S,13S,14S,17S)-13-methyl-7-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl]-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol | |
|---|---|---|
| CAS Number | 129453-61-8 | |
| Molecular Formula |
C32H47F5O3S |
|
| Molecular Weight (MW) | 606.77 | |
| SMILES | CC12CCC3C(C1CCC2O)C(CC4=C3C=CC(=C4)O)CCCCCCCCCS(=O)CCCC(C(F)(F)F)(F)F | |
| InChIKey | VWUXBMIQPBEWFH-WCCTWKNTSA-N |
Fulvestrant (ICI-182780) is a synthetic estrogen receptor (ER) antagonist and selective estrogen receptor down-regulator (SERD). By binding competitively to ER, fulvestrant induces receptor deformation and degradation, thereby blocking estrogen-mediated signaling pathways. This inhibition downregulates ER-dependent gene expression, suppresses tumor cell proliferation, and promotes autophagy and apoptosis in estrogen-sensitive breast cancer cells. [1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(164.8 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(164.8 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(164.8 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(164.8 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(164.8 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Fulvestrant (ICI-182780) Mechanism of Action: ER Inhibition in Breast Cancer Cell Research
- Fulvestrant (ICI-182780) Clinical Trials
- Fulvestrant (ICI-182780): Selectivity & Specificity
- Fulvestrant (ICI-182780) Working Concentration | Cell Culture | Treatment
- Fulvestrant (ICI-182780) Solubility in DMSO
- Fulvestrant (ICI-182780) Stock Solution
- Fulvestrant (ICI-182780) Storage
- Fulvestrant (ICI-182780) Stability
- Fulvestrant (ICI-182780) Combination Database
- Fulvestrant (ICI-182780) Molecular Weight
- Fulvestrant (ICI-182780) SMILES
- Fulvestrant (ICI-182780) Chemical Structure (2D and 3D)
- Fulvestrant (ICI-182780) IC50 for Cell-based and Cell-free Assays
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- Fulvestrant (ICI-182780) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.