CAS No. 245329-02-6 (free base)

Batch: Purity:99.31
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FSLLRY-NH2 TFA Chemical Structure
Chemical Structure
Check the FSLLRY-NH2 TFA product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[1-[[1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-2-[[2-[[2-[(2-amino-3-phenylpropanoyl)amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanamide;2,2,2-trifluoroacetic acid
CAS Number 245329-02-6 (free base)
Molecular Formula

C41H61F3N10O10
Molecular Weight (MW) 910.98
SMILES CC(C)CC(NC(=O)C(CC(C)C)NC(=O)C(CO)NC(=O)C(N)CC1=CC=CC=C1)C(=O)NC(CCCNC(N)=N)C(=O)NC(CC2=CC=C(O)C=C2)C(N)=O.OC(=O)C(F)(F)F
InChIKey YOHKVKBYKRRTME-UHFFFAOYSA-N

Ordering Information

Biological Activity

FSLLRY-NH2 TFA is a peptide-based, selective inhibitor of protease-activated receptor 2 (PAR2). By blocking PAR2 activation, it suppresses downstream intracellular calcium mobilization and inflammatory signaling pathways. This target inhibition effectively reduces PAR2-mediated joint swelling and cellular inflammation in preclinical models, making it a valuable tool for investigating PAR2 receptor function and inflammatory disease mechanisms. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (109.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 50 mg/mL
Ethanol 7 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.