CAS No. 26016-99-9

Batch: Purity:98
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Fosfomycin Disodium Chemical Structure
Chemical Structure
Check the Fosfomycin Disodium product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name disodium;[(2R,3S)-3-methyloxiran-2-yl]-dioxido-oxo-λ5-phosphane
CAS Number 26016-99-9
Molecular Formula

C3H5O4P.2Na
Molecular Weight (MW) 182.02
SMILES CC1C(O1)P(=O)([O-])[O-].[Na+].[Na+]
InChIKey QZIQJIKUVJMTDG-JSTPYPERSA-L

Biological Activity

Fosfomycin Disodium is a broad-spectrum, low-molecular-weight antibiotic that acts as an irreversible inhibitor of UDP-N-acetylglucosamine enolpyruvyl transferase (MurA). By alkylating a key active-site cysteine residue of MurA, it blocks the first committed step in bacterial peptidoglycan biosynthesis. This targeted inhibition disrupts cell wall integrity, leading to bacterial cell lysis and potent bactericidal activity against diverse Gram-positive and Gram-negative pathogens.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 36 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.