CAS No. 26472-47-9
Batch:
Purity:99.15
Chemical Structure
Check the
Fosfomycin calcium
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | calcium [(2R,3S)-3-methyloxiran-2-yl]-dioxido-oxo-λ5-phosphane | |
|---|---|---|
| CAS Number | 26472-47-9 | |
| Molecular Formula |
C3H5O4P.Ca |
|
| Molecular Weight (MW) | 176.12 | |
| SMILES | CC1C(O1)P(=O)([O-])[O-].[Ca+2] | |
| InChIKey | YMZJBJPWTXJQMR-LJUKVTEVSA-L |
Fosfomycin calcium is an antibiotic agent that functions as a broad-spectrum bactericidal inhibitor of UDP-N-acetylglucosamine-3-enolpyruvyltransferase (MurA). Upon uptake into bacterial cells via glycerophosphate transporters, fosfomycin selectively inactivates MurA to block the initial step of bacterial peptidoglycan biosynthesis. This targeted enzyme inactivation disrupts cell wall biogenesis, leading to bacterial cell lysis and potent antimicrobial phenotypes across diverse pathogenic strains.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| 5%TFA | 3.06 mg/mL |
| DMSO |
0.1 mg/mL
(0.56 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.