CAS No. 42835-25-6
| IUPAC Name | 7-fluoro-12-methyl-4-oxo-1-azatricyclo[7.3.1.05,13]trideca-2,5,7,9(13)-tetraene-3-carboxylic acid | |
|---|---|---|
| CAS Number | 42835-25-6 | |
| Molecular Formula |
C14H12FNO3 |
|
| Molecular Weight (MW) | 261.25 | |
| SMILES | CC1CCC2=C3N1C=C(C(=O)C3=CC(=C2)F)C(=O)O | |
| InChIKey | DPSPPJIUMHPXMA-UHFFFAOYSA-N |
Flumequine is a synthetic fluoroquinolone antibiotic that functions as an inhibitor of bacterial DNA gyrase and topoisomerase II. By interfering with bacterial topoisomerase activities, flumequine disrupts DNA replication and transcription processes, leading to inhibition of DNA synthesis and bacterial cell death. It exhibits broad antimicrobial activity against various Gram-negative pathogens by targeting essential bacterial type II topoisomerase complexes. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
3 mg/mL
(11.48 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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