CAS No. 75607-67-9
Batch:
Purity:99.91
Chemical Structure
Check the
Fludarabine (NSC 118218) Phosphate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | [(2R,3S,4S,5R)-5-(6-amino-2-fluoropurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate | |
|---|---|---|
| CAS Number | 75607-67-9 | |
| Molecular Formula |
C10H13FN5O7P |
|
| Molecular Weight (MW) | 365.21 | |
| SMILES | C1=NC2=C(N=C(N=C2N1C3C(C(C(O3)COP(=O)(O)O)O)O)F)N | |
| InChIKey | GIUYCYHIANZCFB-FJFJXFQQSA-N |
Fludarabine Phosphate is a purine nucleoside analogue that acts as a potent DNA synthesis inhibitor. Upon cellular uptake and intracellular conversion to its active triphosphate form, F-ara-ATP, it inhibits essential enzymes required for DNA replication, including DNA polymerase, ribonucleotide reductase, and DNA primase. This inhibition suppresses DNA synthesis and chain elongation, leading to the induction of apoptosis in sensitive cell lines.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
73 mg/mL
(199.88 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 3 mg/mL |
| Ethanol | Insoluble |
| DMSO |
73 mg/mL
(199.88 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 2 mg/mL |
| Ethanol | Insoluble |
| DMSO |
73 mg/mL
(199.88 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 6 mg/mL |
| Ethanol | Insoluble |
| DMSO |
73 mg/mL
(199.88 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 8 mg/mL |
| Ethanol | Insoluble |
| DMSO |
73 mg/mL
(199.88 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 6 mg/mL |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Fludarabine (NSC 118218) Phosphate Clinical Trials
- Fludarabine (NSC 118218) Phosphate Solubility in DMSO
- Fludarabine (NSC 118218) Phosphate Stock Solution
- Fludarabine (NSC 118218) Phosphate Storage
- Fludarabine (NSC 118218) Phosphate Stability
- Fludarabine (NSC 118218) Phosphate Molecular Weight
- Fludarabine (NSC 118218) Phosphate SMILES
- Fludarabine (NSC 118218) Phosphate Chemical Structure (2D and 3D)
- Fludarabine (NSC 118218) Phosphate SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.