CAS No. 1226895-15-3
| IUPAC Name | (E)-3-(3,4-dimethoxyphenyl)-1-[1-[(E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]cyclohexyl]prop-2-en-1-one | |
|---|---|---|
| CAS Number | 1226895-15-3 | |
| Molecular Formula |
C28H32O6 |
|
| Molecular Weight (MW) | 464.55 | |
| SMILES | COC1=C(C=C(C=C1)C=CC(=O)C2(CCCCC2)C(=O)C=CC3=CC(=C(C=C3)OC)OC)OC | |
| InChIKey | NQDROBVIYYEMDQ-WFYKWJGLSA-N |
FLLL32 is a potent small-molecule JAK2 and STAT3 inhibitor that suppresses STAT3 activation. By blocking STAT3 signaling, it effectively inhibits IL-6- and IFNα-stimulated STAT3 phosphorylation at Tyr705. This targeted inhibition disrupts downstream signaling cascades, downregulating anti-apoptotic proteins such as Bcl-2 and survivin, suppressing cell proliferation, and inducing apoptosis in various cancer cell lines including breast and pancreatic cancer cells. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
92 mg/mL
(198.04 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 25 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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