CAS No. 528-48-3
| IUPAC Name | 2-(3,4-dihydroxyphenyl)-3,7-dihydroxychromen-4-one | |
|---|---|---|
| CAS Number | 528-48-3 | |
| Molecular Formula |
C15H10O6 |
|
| Molecular Weight (MW) | 286.24 | |
| InChIKey | XHEFDIBZLJXQHF-UHFFFAOYSA-N |
Fisetin is a natural flavonoid that acts as a potent sirtuin-activating compound (STAC) and modulates SIRT1 activity. It functions as a caloric restriction mimetic, promoting longevity in model organisms including Saccharomyces cerevisiae and Drosophila melanogaster. Furthermore, fisetin exerts anti-inflammatory, anti-carcinogenic, and senolytic effects, suppressing pro-inflammatory signaling pathways and selectively clearing senescent cell populations in preclinical models. [1][2]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
57 mg/mL
(199.13 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 9 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(349.35 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 14 mg/mL |
| Water | Insoluble |
| DMSO |
750 mg/mL
(2620.17 mM)
; Warmed with 60°C water bath
; Ultrasonicated
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
| DMSO |
57 mg/mL
(199.13 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
57 mg/mL
(199.13 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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