CAS No. 1206161-97-8

Batch: Purity:99.76
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Filgotinib (GLPG0634) Chemical Structure
Chemical Structure
Check the Filgotinib (GLPG0634) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[5-[4-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide
CAS Number 1206161-97-8
Molecular Formula

C21H23N5O3S
Molecular Weight (MW) 425.50
SMILES C1CC1C(=O)NC2=NN3C(=N2)C=CC=C3C4=CC=C(C=C4)CN5CCS(=O)(=O)CC5
InChIKey RIJLVEAXPNLDTC-UHFFFAOYSA-N

Ordering Information

Biological Activity

Filgotinib (GLPG0634) is a selective Janus kinase 1 (JAK1) inhibitor with IC50 values of 10 nM for JAK1, 28 nM for JAK2, 116 nM for TYK2, and 810 nM for JAK3. By suppressing JAK/STAT pathway activation, it inhibits downstream signal transducer phosphorylation and blocks pro-inflammatory cytokine signaling, thereby modulating immune responses in preclinical inflammatory disease models.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 21 mg/mL (49.35 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.