CAS No. 172922-91-7

Batch: Purity:99.05
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FICZ (6-Formylindolo[3,2-b]carbazole) Chemical Structure
Chemical Structure
Check the FICZ (6-Formylindolo[3,2-b]carbazole) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 5,11-dihydroindolo[3,2-b]carbazole-12-carbaldehyde
CAS Number 172922-91-7
Molecular Formula

C19H12N2O
Molecular Weight (MW) 284.31
SMILES O=CC1=C2C(=CC3=C1[NH]C4=C3C=CC=C4)[NH]C5=C2C=CC=C5
InChIKey ZUDXFBWDXVNRKF-UHFFFAOYSA-N

Biological Activity

FICZ is a high-affinity agonist of the aryl hydrocarbon receptor (AhR) with a Kd of. Activation of AhR by FICZ drives the gene expression of cytochrome P4501 (CYP1) enzymes, particularly CYP1A1, which in turn metabolize FICZ in an autoregulatory feedback loop. This signaling pathway regulates xenobiotic metabolism, mucosal immunity, and T helper 17 cell differentiation. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 57 mg/mL (200.48 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Virus Research. 1998;56(1):123-124.

[2] Wincent E, et al. J Biol Chem. 2009;284(5):2690-2696.

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Note: Technical data last updated: Sep 1, 2026.