Ferrostatin-1 (Fer-1): Mechanism of Action

Ferrostatin-1 (Fer-1) MOA:Targeting Lipid Peroxidation/Ferroptosis Pathway for Oncology

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Ferrostatin-1 is a potent, selective ferroptosis inhibitor. It affects Nrf2/GPX4, TGF-β/Smad, and NF-κB signaling by scavenging lipid reactive oxygen species, preventing iron accumulation, and restoring GPX4 expression, effectively inhibiting ferroptosis, mitigating oxidative stress, and protecting cells from injury.

Primary Applications and Mechanism of Action