Ferrostatin-1 is a potent, selective ferroptosis inhibitor. It affects Nrf2/GPX4, TGF-β/Smad, and NF-κB signaling by scavenging lipid reactive oxygen species, preventing iron accumulation, and restoring GPX4 expression, effectively inhibiting ferroptosis, mitigating oxidative stress, and protecting cells from injury.
Ferrostatin-1 (Fer-1) IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for Ferrostatin-1 (Fer-1) Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.