CAS No. 65646-68-6
| CAS Number | 65646-68-6 | |
|---|---|---|
| Molecular Formula |
C26H33NO2 |
|
| Molecular Weight (MW) | 391.55 | |
| SMILES | CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)NC2=CC=C(C=C2)O)C)C |
Fenretinide (4-HPR) is a synthetic derivative of retinoic acid that functions as a retinoid receptor ligand, binding to retinoic acid receptor (RAR) and retinoid X receptor (RXR). By interacting with these nuclear receptors and modulating intracellular signaling, fenretinide triggers reactive oxygen species generation and induces apoptosis. It exhibits broad-spectrum cytotoxic activity against various cancer cell lines and primary tumor models, particularly human neuroblastoma cells.
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
78 mg/mL
(199.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 78 mg/mL |
| Water | Insoluble |
| DMSO |
78 mg/mL
(199.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 78 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.