CAS No. 13636-18-5

Batch: Purity:99.86
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Fendiline hydrochloride Chemical Structure
Chemical Structure
Check the Fendiline hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 3,3-diphenyl-N-(1-phenylethyl)propan-1-amine;hydrochloride
CAS Number 13636-18-5
Molecular Formula

C23H25N.HCl
Molecular Weight (MW) 351.91
SMILES CC(C1=CC=CC=C1)NCCC(C2=CC=CC=C2)C3=CC=CC=C3.Cl
InChIKey NJXWZWXCHBNOOG-UHFFFAOYSA-N

Ordering Information

Biological Activity

Fendiline hydrochloride is an L-type calcium channel blocker and a selective inhibitor of K-Ras plasma membrane localization. By disrupting the association of K-Ras with the plasma membrane without affecting H-Ras or N-Ras trafficking, it impairs downstream Ras signaling pathways including MAPK and AKT. Consequently, fendiline hydrochloride inhibits cell proliferation and suppresses tumor growth in Ras-dependent cancer models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 70 mg/mL (198.91 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.