CAS No. 298197-04-3
| IUPAC Name | 4-(4-methylphenyl)-2-(2-propyl-4-pyridinyl)-1,3-thiazole;hydrobromide | |
|---|---|---|
| CAS Number | 298197-04-3 | |
| Molecular Formula |
C18H18N2S·HBr |
|
| Molecular Weight (MW) | 375.33 | |
| SMILES | CCCC1=NC=CC(=C1)C2=NC(=CS2)C3=CC=C(C=C3)C.Br | |
| InChIKey | RJCFNQZVFUMORB-UHFFFAOYSA-N |
Fatostatin Hydrobromide is a selective inhibitor of sterol regulatory element-binding proteins, impairing the activation of both SREBP-1 and SREBP-2. By directly binding to SREBP cleavage-activating protein (SCAP), it blocks the ER-to-Golgi translocation of SREBPs. This disrupts lipogenic gene expression, leading to decreased lipid accumulation, reduced fatty acid and cholesterol synthesis, and suppressed cell proliferation in various metabolic and cancer cell models. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| Ethanol | 58 mg/mL |
| DMSO |
7 mg/mL
(18.65 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| DMSO |
38 mg/mL
(101.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 10 mg/mL |
| Water | Insoluble |
| DMSO |
38 mg/mL
(101.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
| DMSO |
38 mg/mL
(101.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
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