CAS No. 2639957-39-2

Batch: Purity:99.10
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Exarafenib (KIN-2787) Chemical Structure
Chemical Structure
Check the Exarafenib (KIN-2787) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (3S)-N-[3-[2-[[(2R)-1-hydroxypropan-2-yl]amino]-6-morpholin-4-yl-4-pyridinyl]-4-methylphenyl]-3-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide
CAS Number 2639957-39-2
Molecular Formula

C26H34F3N5O3
Molecular Weight (MW) 521.58
InChIKey GZMYLSJUNSCMTD-MOPGFXCFSA-N

Ordering Information

Biological Activity

Exarafenib (KIN- is an orally available, selective pan-RAF inhibitor that potently targets ARAF, BRAF, and RAF1. By intercepting RAF proteins in a dimer-compatible conformation, exarafenib suppresses downstream MAPK signaling cascade activation. This pathway blockade inhibits cellular proliferation and exhibits broad antitumor efficacy in preclinical models harboring class I, II, and III BRAF alterations as well as NRAS mutations. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (191.72 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.