CAS No. 1415823-73-2
| IUPAC Name | 1-[4-[[[6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl]amino]methyl]piperidin-1-yl]prop-2-en-1-one | |
|---|---|---|
| CAS Number | 1415823-73-2 | |
| Molecular Formula |
C25H27N5O2 |
|
| Molecular Weight (MW) | 429.51 | |
| SMILES | C=CC(=O)N1CCC(CC1)CNC2=NC=NC(=C2C3=CC=C(C=C3)OC4=CC=CC=C4)N | |
| InChIKey | QUIWHXQETADMGN-UHFFFAOYSA-N |
Evobrutinib is a potent and highly selective Bruton's tyrosine kinase (BTK) inhibitor. By covalently binding to the active site of BTK, it effectively disrupts B-cell receptor signaling pathways and suppresses downstream B-cell activation, cellular proliferation, and pro-inflammatory cytokine production. Additionally, evobrutinib inhibits Fc receptor-mediated signaling in myeloid lineage cells, demonstrating broad immunomodulatory activity and potential anti-neoplastic effects. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
86 mg/mL
(200.22 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 10 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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