CAS No. 1186486-62-3

Batch: Purity:99.83
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Evacetrapib (LY2484595) Chemical Structure
Chemical Structure
Check the Evacetrapib (LY2484595) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[[(5S)-5-[[3,5-bis(trifluoromethyl)phenyl]methyl-(2-methyltetrazol-5-yl)amino]-7,9-dimethyl-2,3,4,5-tetrahydro-1-benzazepin-1-yl]methyl]cyclohexane-1-carboxylic acid
CAS Number 1186486-62-3
Molecular Formula

C31H36F6N6O2
Molecular Weight (MW) 638.65
SMILES CC1=CC(=C2C(=C1)C(CCCN2CC3CCC(CC3)C(=O)O)N(CC4=CC(=CC(=C4)C(F)(F)F)C(F)(F)F)C5=NN(N=N5)C)C
InChIKey IHIUGIVXARLYHP-UXNJHFGPSA-N

Ordering Information

Biological Activity

Evacetrapib (LY2484595) is a potent inhibitor of cholesteryl ester transfer protein (CETP). By inhibiting CETP activity, it suppresses the transfer of cholesteryl esters from high-density lipoprotein (HDL) to pro-atherogenic lipoproteins, leading to elevated HDL cholesterol levels and apolipoprotein A-I concentrations. Furthermore, evacetrapib produces targeted CETP inhibition without inducing adverse increases in aldosterone secretion or blood pressure. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 12.8 mg/mL (20.04 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 12.8 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.