CAS No. 434-03-7
Batch:
Purity:99.32
Chemical Structure
Check the
Ethisterone
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 434-03-7 | |
|---|---|---|
| Molecular Formula |
C21H28O2 |
|
| Molecular Weight (MW) | 312.45 | |
| SMILES | CC12CCC(=O)C=C1CCC3C2CCC4(C3CCC4(C#C)O)C |
Ethisterone is a synthetic progestogen hormone that acts as a progesterone receptor agonist. Upon binding to nuclear progesterone receptors, it modulates steroid receptor-mediated transcriptional activity and downregulates hormone-dependent signaling pathways. These cellular interactions regulate gene expression involved in tissue differentiation, cellular proliferation, and endocrine responses, demonstrating inhibitory potential in hormone-sensitive prostate and reproductive cancer models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
0.05 mg/mL
(0.16 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
4 mg/mL
(12.8 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.