Clinical Trials

Numerous clinical trials evaluate estradiol-related therapies across diverse conditions, including reproductive health, menopausal indications, atrophic vaginitis, systemic scleroderma, arteriosclerosis, and HIV infections. Spanning phase 1 through phase 4, these studies examine parameters such as therapeutic equivalence and drug-drug interactions across active, recruiting, completed, terminated, and withdrawn recruitment statuses. Sponsored by major pharmaceutical corporations and academic medical centers, these investigations rigorously assess bioequivalence, efficacy, and regulatory compliance across varied physiological contexts.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT07574216 NOT_YET_RECRUITING
Post-menopause; Pre-menopause; Sexual Function; Menopause; Vaginal Dryness; Painful Intercourse
University of Arizona
 2026-06-01
NCT07420218 NOT_YET_RECRUITING
Perimenopausal Women
University of Delaware
 2026-09-01 PHASE4
NCT07526948 NOT_YET_RECRUITING
Menopausal Complaints; Vaginal Atrophy; Genitourinary Symptoms; HIV (Human Immunodeficiency Virus); Menopause Related Conditions; Vaginitis; Perimenopause
Albert Einstein College of Medicine
 2026-09 PHASE4
NCT07536763 NOT_YET_RECRUITING
Contraception
Dr. Hang Wun Raymond Li
 2026-07 PHASE3
NCT07041814 NOT_YET_RECRUITING
Turner Syndrome
Universiti Kebangsaan Malaysia Medical Centre
 2026-02-15 PHASE2
NCT06369363 NOT_YET_RECRUITING
Postmenopausal Symptoms; Cardiovascular Diseases
Milton S. Hershey Medical Center
 2026-09 EARLY_PHASE1
NCT07620587 RECRUITING
Energy Balance; Physiology - Regulation of Appetite and Food Intake
Wilfrid Laurier University
 2026-06-01
NCT07100782 RECRUITING
Endometriosis; Pelvic Pain
University of Michigan
 2025-12-08 PHASE3
NCT06439524 RECRUITING
Endometriosis
Main Line Health
 2024-08-15 PHASE3
NCT06610305 RECRUITING
Major Depressive Disorder
University of North Carolina, Chapel Hill
 2024-09-02 PHASE4
NCT07568574 ENROLLING_BY_INVITATION
Safety and Impact of Medically Supervised Performance Enhancing Substance Usage in Healthy Elite Athletes
Enhanced Emirates Limited
 2026-03-12
NCT06334315 RECRUITING
Contraception; Pharmacogenomic Drug Interaction
Yale University
 2024-10-29 PHASE4
NCT07544966 NOT_YET_RECRUITING
Depression - Major Depressive Disorder; Irritability
University of North Carolina, Chapel Hill
 2026-10-01 PHASE4
NCT07340190 RECRUITING
Advanced Malignancies
Novartis Pharmaceuticals
 2026-06-12 PHASE1
NCT07419594 RECRUITING
PTSD; Intrusive Memories; Intrusion Symptom; Trauma; Intrusion
Charite University, Berlin, Germany
 2024-08-19
NCT05900895 RECRUITING
Metastatic Breast Cancer
Mary D Chamberlin
 2024-07-15 PHASE1
NCT04833140 ACTIVE_NOT_RECRUITING
NASH - Nonalcoholic Steatohepatitis
Massachusetts General Hospital
 2021-12-02 PHASE3
NCT07013643 RECRUITING
Healthy Participants
AstraZeneca
 2025-06-04 PHASE1
NCT04783857 RECRUITING
Smoking; Smoking Cessation; Smoking Reduction
University of Minnesota
 2022-04-14 PHASE4
NCT07525791 RECRUITING
Overweight; Obesity
Novo Nordisk A/S
 2026-04-07 PHASE1
NCT07568509 RECRUITING
Arginine Vasopressin Deficiency; Oxytocin Deficiency; Pediatric Disease; Hypopituitarism
Massachusetts General Hospital
 2026-08-17 EARLY_PHASE1
NCT06179303 RECRUITING
Anatomic Stage III Breast Cancer AJCC v8; Anatomic Stage IV Breast Cancer AJCC v8; Locally Advanced Unresectable HER2-Negative Breast Carcinoma; Locally Advanced Unresectable Hormone Receptor-Positive Breast Carcinoma; Metastatic HER2-Negative Breast Carcinoma; Metastatic Hormone Receptor-Positive Breast Carcinoma
University of Washington
 2024-07-22 PHASE2
NCT05723601 ACTIVE_NOT_RECRUITING
Recurrent Urinary Tract Infection
Wake Forest University Health Sciences
 2024-01-12 PHASE4
NCT04685148 RECRUITING
Major Depressive Disorder; Postpartum Depression
Vibe G Frøkjær, MD, PhD
 2021-02-03 PHASE1; PHASE2
NCT07446400 RECRUITING
Healthy Volunteers
Otsuka Pharmaceutical Development & Commercialization, Inc.
 2026-03-31 PHASE1
NCT06798571 RECRUITING
Menopause; Aging
Penn State University
 2025-03-01 PHASE4
NCT07083635 RECRUITING
Menstruation Disturbances; Metrorrhagia; Uterine Hemorrhage; Contraception Behavior
Chulalongkorn University
 2025-07-29 PHASE2
NCT07381569 NOT_YET_RECRUITING
Abortion, Induced
Peking Union Medical College Hospital
 2026-03-01
NCT06343870 RECRUITING
Menopause; Testosterone Deficiency; Estrogen Deficiency
University of Sao Paulo General Hospital
 2025-12-18 PHASE3
NCT07502417 COMPLETED
Healthy Volunteer
AbbVie
 2026-03-27 PHASE1
NCT07379502 NOT_YET_RECRUITING
PCOS (Polycystic Ovary Syndrome)
CMH Kharian Medical College
 2026-03-05
NCT07242131 RECRUITING
Polycystic Ovary Syndrome (PCOS)
Ege University
 2025-12-01
NCT07754630 ACTIVE_NOT_RECRUITING
Menopause; Hypoestrogenism; Hormonal Therapy
Nutrindo Ideais Research Center
 2025-02-25 PHASE2
NCT06460948 COMPLETED
Arginine Vasopressin Deficiency; Oxytocin Deficiency
Elizabeth Austen Lawson
 2024-11-13 EARLY_PHASE1
NCT07269327 COMPLETED
Fertility
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
 2025-11-24 PHASE1
NCT07727863 COMPLETED
PCOS GnRH Antagonist and GnRH Agonist IVF/ICSI Cycles; IVF Outcomes
Cairo University
 2024-09-13
NCT07272889 COMPLETED
Healthy Volunteer Study
Atea Pharmaceuticals, Inc.
 2025-12-04 PHASE1
NCT06942936 COMPLETED
Healthy Participants
AstraZeneca
 2025-05-28 PHASE1
NCT07160504 RECRUITING
Vagina Atrophy
University of Aarhus
 2025-03-21 PHASE4
NCT04828824 COMPLETED
Contraception Behavior
University of Colorado, Denver
 2021-06-18 PHASE4
NCT06279195 WITHDRAWN
Pelvic Pain
Endeavor Health
 2024-06-01 PHASE2
NCT03873428 UNKNOWN
FES TEP in Detection of Estrogen Receptors
Centre Georges Francois Leclerc
 2021-10-18
NCT04597099 UNKNOWN
PCOS; Polycystic Ovary Syndrome
University of Virginia
 2022-10-26 EARLY_PHASE1
NCT03401047 RECRUITING
Polycystic Ovary Syndrome
University of Virginia
 2017-11-30 EARLY_PHASE1
NCT01425541 UNKNOWN
Hyperandrogenemia; Polycystic Ovary Syndrome (PCOS)
University of Virginia
 2000-04
NCT05551949 COMPLETED
Recurrent Urinary Tract Infection; Urinary Tract Infections; Cystitis Recurrent
Johns Hopkins University
 2022-01-01 PHASE4
NCT05982470 UNKNOWN
Cerebral Small Vessel Diseases; Postmenopausal Symptoms; Mild Cognitive Impairment; White Matter Hyperintensity
Beijing Tiantan Hospital
 2023-08-18 PHASE2
NCT04447872 UNKNOWN
Infertility; Diminished Ovarian Reserve; IVF
Northwell Health
 2020-09-15
NCT03973229 COMPLETED
PTSD; Trauma
Emory University
 2019-11-11 EARLY_PHASE1
NCT06461039 COMPLETED
Obesity
Novo Nordisk A/S
 2024-06-14 PHASE1
NCT06799884 COMPLETED
Drug Drug Interaction
Idorsia Pharmaceuticals Ltd.
 2025-01-18 PHASE1
NCT05896384 COMPLETED
Healthy
Boehringer Ingelheim
 2023-12-21 PHASE1
NCT06657105 COMPLETED
Healthy Participants
AstraZeneca
 2024-11-01 PHASE1
NCT03976544 TERMINATED
Miscarriage; Frozen Embryo Transfer; Natural Cycle; Hormone Replacement Therapy Cycle; Preimplantation Genetic Screening; Euploid Embryos
CRG UZ Brussel
 2019-05-25 PHASE4
NCT02330757 UNKNOWN
Infertility
Mansoura University
 2016-10-10 PHASE4
NCT06358014 UNKNOWN
Postmenopausal Depression; Estrogen
Xiao Wang
 2023-05-12
NCT06191289 TERMINATED
Suicide
University of Illinois at Chicago
 2024-03-16 PHASE2
NCT05780489 UNKNOWN
Infertility, Female; Reproductive Sterility
Instituto Valenciano de Infertilidad, IVI VALENCIA
 2023-04-14
NCT06181305 UNKNOWN
IVF
Rahem Fertility Center
 2024-02-24 PHASE4
NCT04595682 COMPLETED
Alcohol Use, Unspecified
Mark Fillmore
 2021-03-15
NCT05663892 ACTIVE_NOT_RECRUITING
Hiv; Transgenderism
Maple Leaf Research
 2022-11-23 PHASE4
NCT06508944 COMPLETED
Lower Urinary Tract Symptoms; Female Genitourinary Disease; Urinary Stress Incontinence; Urinary Urge Incontinence; Nocturia; Quality of Life; Voiding Disorders; Vagina Atrophy; Urethral Atrophy; Overactive Bladder; Overactive Bladder Syndrome; Bladder, Overactive
Mahidol University
 2024-04-08 PHASE4
NCT06654570 COMPLETED
Breast Cancer
Helsinki University Central Hospital
 2020-04-08 PHASE2
NCT06310616 COMPLETED
HIV Infections
ViiV Healthcare
 2024-03-06 PHASE1
NCT03941730 ACTIVE_NOT_RECRUITING
Advanced Triple-Negative Breast Carcinoma; Anatomic Stage III Breast Cancer AJCC v8; Anatomic Stage IV Breast Cancer AJCC v8; Metastatic Triple-Negative Breast Carcinoma; Recurrent Breast Carcinoma
Mayo Clinic
 2019-08-28 PHASE2
NCT06039826 COMPLETED
Overweight
Eli Lilly and Company
 2023-09-12 PHASE1
NCT06354257 COMPLETED
Tuberculosis
GlaxoSmithKline
 2024-04-05 PHASE1
NCT05227391 UNKNOWN
PCOS
Reproductive & Genetic Hospital of CITIC-Xiangya
 2022-03-16
NCT03271489 COMPLETED
Heavy Menstrual Bleeding; Uterine Fibroids
AbbVie
 2017-09-13 PHASE3
NCT06380205 COMPLETED
Healthy Participants
Incyte Corporation
 2024-05-07 PHASE1
NCT06250205 COMPLETED
Healthy Volunteers
NewAmsterdam Pharma
 2024-02-05 PHASE1
NCT06233071 UNKNOWN
Healthy Subjects
Bio-innova Co., Ltd
 2024-02-13 PHASE1
NCT05802303 TERMINATED
Frozen Embryo Transfer; Infertility, Female
Indira IVF Hospital Pvt Ltd
 2023-07-25
NCT05617820 COMPLETED
Dyspareunia
Teva Pharmaceuticals USA
 2022-11-15 PHASE3
NCT03844412 COMPLETED
Vestibulodynia; Temporomandibular Disorder; Fibromyalgia Syndrome; Irritable Bowel Syndrome; Migraines; Tension Headache; Endometriosis; Interstitial Cystitis; Back Pain; Chronic Fatigue Syndrome
Duke University
 2019-11-04 PHASE2
NCT05232344 COMPLETED
Infertility
University Hospital, Montpellier
 2022-04-13
NCT04590417 ACTIVE_NOT_RECRUITING
Drug Interaction
Thai Red Cross AIDS Research Centre
 2022-01-24
NCT03106454 COMPLETED
Contraception; Ovulation
University of Southern California
 2014-08 PHASE3
NCT03981341 UNKNOWN
Sleep Apnea; Post Menopausal; Oxidative Stress
Laval University
 2019-11-01 PHASE3
NCT04899778 COMPLETED
Ligament Injury
Cedars-Sinai Medical Center
 2021-09-29 PHASE4
NCT05951413 UNKNOWN
IVF
Beni-Suef University
 2023-06-30 PHASE2; PHASE3
NCT06144814 COMPLETED
Vulvovaginal Atrophy
Koru Health Groups
 2023-04-05
NCT03815929 COMPLETED
Cardiovascular Risk Reduction
Mayo Clinic
 2019-03-15 PHASE2
NCT06316206 COMPLETED
Endometrial Polyp; Endometrial Diseases
University of Palermo
 2023-01-01 PHASE4
NCT06324851 COMPLETED
Endometrial Polyp; Endometrial Diseases
University of Palermo
 2023-01-01 PHASE4
NCT05010707 COMPLETED
Transgenderism
Washington University School of Medicine
 2021-08-02 PHASE2
NCT05706753 COMPLETED
Healthy Female
Janssen Pharmaceutica N.V., Belgium
 2023-01-25 PHASE1
NCT07398924 COMPLETED
Female Infertility; Anovulatory Infertility; Unexplained Infertility
Yuzuncu Yil University
 2022-01-06
NCT04190927 UNKNOWN
Menopause; Perimenopausal Disorder; Menopause Related Conditions
Women's Hormone Network
 2020-06-01 PHASE4
NCT05579574 COMPLETED
Healthy Participants
Bristol-Myers Squibb
 2022-10-21 PHASE1
NCT05458375 TERMINATED
Pelvic Organ Prolapse; Urinary Incontinence; Pessary Ulcer of Vagina; Vaginal Atrophy
University of South Florida
 2022-12-29 EARLY_PHASE1
NCT05300841 UNKNOWN
PCOS; ICSI
Sohag University
 2022-05-01 EARLY_PHASE1
NCT05161338 COMPLETED
Infertility, Female
Instituto Valenciano de Infertilidad, IVI VALENCIA
 2022-02-15
NCT03726931 COMPLETED
Breast Cancer
Amsterdam UMC, location VUmc
 2018-11-13
NCT03442504 UNKNOWN
Metastatic Breast Cancer
Institut Cancerologie de l'Ouest
 2017-03-15
NCT05505162 COMPLETED
Healthy Female Participants
AstraZeneca
 2022-08-24 PHASE1
NCT05367973 COMPLETED
Vulvovaginal Atrophy; Vasomotor Symptoms
Daré Bioscience, Inc.
 2022-04-11 PHASE1; PHASE2
NCT04021017 WITHDRAWN
Anorexia Nervosa
University of Saskatchewan
 2020-01-21 PHASE1
NCT05556317 UNKNOWN
Sleep Disturbances and Insomnia
Cairo University
 2022-09-30
NCT04150731 COMPLETED
Breast Cancer
University of Aarhus
 2020-10-23 PHASE1; PHASE2
NCT01973816 COMPLETED
Endometriosis
University Hospital, Rouen
 2014-09-09 PHASE3
NCT03745144 COMPLETED
Relapsing Multiple Sclerosis (RMS)
Merck KGaA, Darmstadt, Germany
 2019-01-17 PHASE1
NCT05156814 UNKNOWN
Perimenopausal Disorder; Hot Flashes
Scientific Research Institute of Public Health, Russian Federation
 2021-11-29 PHASE4
NCT03047330 COMPLETED
Menopause
Brigham and Women's Hospital
 2017-07-15 PHASE4
NCT05093205 COMPLETED
Healthy Adults
Pfizer
 2021-10-25 PHASE1
NCT05184777 COMPLETED
Infertility, Female; Reproductive Sterility
Instituto Valenciano de Infertilidad, IVI VALENCIA
 2022-02-03
NCT04278755 TERMINATED
Bulimia Nervosa; Binge Eating; Eating Disorders; Binge-Eating Disorder
University of North Carolina, Chapel Hill
 2020-09-24 PHASE2
NCT03236545 COMPLETED
Cardiovascular Risk Factor
University of Delaware
 2016-07-01
NCT04225221 COMPLETED
Bulimia Nervosa
University of North Carolina, Chapel Hill
 2020-02-24 PHASE2
NCT05332106 COMPLETED
Bioequivalence
Laboratorios Andromaco S.A.
 2022-03-12 PHASE1
NCT05282940 COMPLETED
Therapeutic Equivalency
Laboratorios Andromaco S.A.
 2022-02-26 PHASE1
NCT03416764 UNKNOWN
Posttraumatic Stress Disorder (PTSD)
Tel-Aviv Sourasky Medical Center
 2019-01-13
NCT04934696 COMPLETED
Healthy Participants
Bristol-Myers Squibb
 2021-08-03 PHASE1
NCT05064332 COMPLETED
Healthy
Pfizer
 2021-10-08 PHASE1
NCT03654274 COMPLETED
Endometriosis
Myovant Sciences GmbH
 2018-05-22 PHASE3
NCT00303784 UNKNOWN
Anemia; Cardiovascular Complications; Hot Flashes; Osteoporosis; Prostate Cancer
University College, London
 2006-03 PHASE3
NCT05774405 COMPLETED
COVID-19; Hormone Replacement Therapy
Istanbul University - Cerrahpasa
 2020-07-01 PHASE2
NCT01822288 COMPLETED
Menopausal Syndromes
Far Eastern Memorial Hospital
 2012-11-16 PHASE4
NCT06116201 COMPLETED
Transgender Women
Chulalongkorn University
 2020-08-15
NCT04272008 COMPLETED
Contraception
TherapeuticsMD
 2020-03-06 PHASE1
NCT03809546 COMPLETED
Differential Female Response to Δ9-tetrahydrocannabinol (THC)
University of Chicago
 2018-11-06 EARLY_PHASE1
NCT03724955 WITHDRAWN
Cystic Fibrosis Related Bone Disease
Emory University
 2019-04 PHASE4
NCT05418426 COMPLETED
Vulvovaginal Atrophy; Vasomotor Symptoms
Daré Bioscience, Inc.
 2020-08-18 PHASE1
NCT05143723 UNKNOWN
Infertility
Kuban State Medical University
 2020-01-20 PHASE2
NCT04002635 WITHDRAWN
Infertility, Female; Polycystic Ovary Syndrome; IVF; Ovulation Disorder
CRG UZ Brussel
 2020-12-01 PHASE4
NCT03930706 COMPLETED
Infertility
Universitair Ziekenhuis Brussel
 2018-10-01
NCT04714554 COMPLETED
Healthy
Myovant Sciences GmbH
 2021-01-06 PHASE1
NCT05197374 COMPLETED
Female Infertility
Alexandria University
 2020-06-01 PHASE4
NCT04230070 COMPLETED
Bioequivalence
Laboratorios Andromaco S.A.
 2020-10-24 PHASE1
NCT04093518 UNKNOWN
Schizophrenia; Schizoaffective Disorder; Schizophreniform Disorders
Tangent Data
 2019-12-02 PHASE3
NCT03890042 COMPLETED
Adenomyosis
Assiut University
 2019-03-01
NCT04309643 COMPLETED
Healthy Volunteers
Concert Pharmaceuticals
 2020-06-09 PHASE1
NCT02460445 COMPLETED
Hyperandrogenism; Metabolic Cardiovascular Syndrome
Manuel Luque Ramírez
 2015-01
NCT01265017 WITHDRAWN
Type 1 Diabetes
Sansum Diabetes Research Institute
 2012-07 PHASE1
NCT03003949 TERMINATED
Perimenopausal Disorder; Stress, Emotional
University of North Carolina, Chapel Hill
 2017-01-24 PHASE4
NCT03213457 COMPLETED
Endometriosis
AbbVie
 2017-07-07 PHASE3
NCT03412890 COMPLETED
Heavy Menstrual Bleeding; Uterine Fibroid
Myovant Sciences GmbH
 2017-10-19 PHASE3
NCT04142762 COMPLETED
Chronic Hepatitis B
Assembly Biosciences
 2019-10-18 PHASE1
NCT03854175 UNKNOWN
Infertility
Cairo University
 2019-02
NCT03832894 UNKNOWN
Infertility
Cairo University
 2018-12-01 PHASE3
NCT04018274 COMPLETED
Healthy
Pfizer
 2019-08-09 PHASE1
NCT04709094 COMPLETED
Healthy
Alexion Pharmaceuticals, Inc.
 2019-07-28 PHASE1
NCT03675581 COMPLETED
Scleroderma, Systemic
Boehringer Ingelheim
 2018-11-08 PHASE1
NCT01980680 COMPLETED
Infertility
Peter Humaidan
 2014-12 PHASE4
NCT02705963 COMPLETED
Solid Tumors
Novartis Pharmaceuticals
 2016-10-20 PHASE1
NCT03984825 COMPLETED
HIV Infections
ViiV Healthcare
 2019-06-13 PHASE1
NCT03788681 UNKNOWN
ICSI
Ain Shams University
 2018-04-01 PHASE3
NCT06312033 COMPLETED
Emotion Regulation; Estradiol
International Research Training Group 2804
 2018-08-01
NCT04964193 COMPLETED
Drug Use
PT Sydna Farma
 2019-03-12
NCT03049735 COMPLETED
Heavy Menstrual Bleeding; Uterine Fibroid
Myovant Sciences GmbH
 2017-04-26 PHASE3
NCT02859285 COMPLETED
Hypoactive Sexual Desire Disorder
ProHealth Care, Inc
 2016-04
NCT01301183 COMPLETED
Anorexia Nervosa
Massachusetts General Hospital
 2011-02 PHASE3
NCT03662516 COMPLETED
Healthy Females
Pfizer
 2018-09-26 PHASE1
NCT03608241 COMPLETED
Healthy Females
Pfizer
 2018-09-21 PHASE1
NCT04418908 COMPLETED
Type 1 Diabetes
University of Colorado, Denver
 2010-11-24
NCT02255175 COMPLETED
Perimenopausal Depression
University of North Carolina, Chapel Hill
 2015-10-01 PHASE4
NCT03506399 WITHDRAWN
Healthy
Eli Lilly and Company
 2018-06 PHASE1
NCT02744131 UNKNOWN
Polycystic Ovary Syndrome
Kar Clinic & Hospital Pvt. Ltd.
 2016-05
NCT02238808 ACTIVE_NOT_RECRUITING
Estrogen Receptor Positive Breast Cancer
AHS Cancer Control Alberta
 2015-08 PHASE2
NCT03353857 COMPLETED
Biological Availability
Bayer
 2017-11-29 PHASE1
NCT03301233 COMPLETED
Endometrial Thickness
Ain Shams University
 2017-11-01
NCT03120728 UNKNOWN
Emergency Contraception; Healthy, Reproductive Age Women
University of Southern California
 2017-07-10 PHASE4
NCT02475265 COMPLETED
Anorexia Nervosa; Osteoporosis
Massachusetts General Hospital
 2015-07 PHASE2
NCT03210246 COMPLETED
Clinical Trial ,Phase I
Bayer
 2017-07-17 PHASE1
NCT03091595 COMPLETED
Prevention of Pregnancy
Estetra
 2017-02-07 PHASE2
NCT03346317 UNKNOWN
Intrauterine Adhesion
Beijing Obstetrics and Gynecology Hospital
 2017-11-16
NCT03069781 WITHDRAWN
Muscle Atrophy
McMaster University
 2017-05 EARLY_PHASE1
NCT03332303 COMPLETED
Vulvar and Vaginal Atrophy
Prasco LLC
 2017-10-26 PHASE3
NCT03236740 COMPLETED
PCOS
S.C.B. Medical College and Hospital
 2017-08-01 PHASE4
NCT03077555 COMPLETED
Ovulation Inhibition
Mahidol University
 2017-01-21 PHASE4
NCT03238092 UNKNOWN
Fertility Disorders
Hospital de Clinicas de Porto Alegre
 2017-08 PHASE3
NCT03262740 COMPLETED
Rheumatoid Arthritis
Bristol-Myers Squibb
 2017-09-11 PHASE1
NCT01941134 WITHDRAWN
Bariatric Surgery Candidate; Contraception
Johns Hopkins University
 2013-04 PHASE4
NCT02751385 TERMINATED
Carcinoma, Non-Small-Cell Lung
Boehringer Ingelheim
 2016-05-20 PHASE1
NCT03262727 COMPLETED
Systemic Lupus Erythematosus; Arthritic Psoriasis; Psoriasis; Inflammatory Bowel Diseases
Bristol-Myers Squibb
 2017-09-01 PHASE1
NCT03720847 COMPLETED
Suicidal Ideation
University of North Carolina, Chapel Hill
 2016-12-31 PHASE4
NCT02697851 TERMINATED
HIV
St Stephens Aids Trust
 2016-07 PHASE1
NCT02957630 COMPLETED
Contraception; Liver Metabolism; Hemostasis Parameter
Estetra
 2016-09 PHASE1; PHASE2
NCT03155048 COMPLETED
Infertility
Memorial Sisli Hospital, Istanbul
 2017-05-01
NCT02617537 WITHDRAWN
Dysmenorrhea
Bayer
 2016-01 PHASE3
NCT01428193 TERMINATED
Polycystic Ovary Syndrome; Hyperandrogenism
University of Virginia
 2006-09
NCT03126097 TERMINATED
Healthy
Janssen Research & Development, LLC
 2017-04-13 PHASE1
NCT02292732 WITHDRAWN
Cancer
GlaxoSmithKline
 2016-02 PHASE1
NCT02866786 COMPLETED
Polycystic Ovary Syndrome
S.C.B. Medical College and Hospital
 2016-08-15 PHASE4
NCT02846142 COMPLETED
Healthy Volunteer
Proteostasis Therapeutics, Inc.
 2016-06 PHASE1
NCT02626208 COMPLETED
Suppression of Ovulation
Premier Research
 2016-01 PHASE2
NCT03294538 COMPLETED
Atrophic Vaginitis
Actavis Inc.
 2016-05-18 PHASE3
NCT03333564 COMPLETED
Vitamin D Deficiency
Applied Science Private University
 2016-11
NCT02845219 COMPLETED
Diabetes; Diabetes Mellitus, Type 2
Novo Nordisk A/S
 2016-07 PHASE1
NCT02531321 TERMINATED
Contraception; HIV
University of Southern California
 2015-08 PHASE4
NCT01942668 COMPLETED
Menopause
TherapeuticsMD
 2013-08-05 PHASE3
NCT02832180 COMPLETED
Arthritis
Bristol-Myers Squibb
 2016-05 PHASE1
NCT01862835 COMPLETED
Normal Healthy Volunteers
Mayo Clinic
 2013-05 PHASE1
NCT02668796 COMPLETED
Vulvar and Vaginal Atrophy
Glenmark Pharmaceuticals Ltd. India
 2016-01 PHASE3
NCT03848234 COMPLETED
Schizophrenia; Schizoaffective Disorder; Schizophreniform Disorders
Tangent Data
 2015-12-04 PHASE3
NCT02652650 COMPLETED
Healthy
Janssen Research & Development, LLC
 2015-12 PHASE1
NCT02218463 COMPLETED
Prepubertal Labial Adhesions
Children's Mercy Hospital Kansas City
 2014-09
NCT02271282 COMPLETED
Normal Healthy Volunteers
Mayo Clinic
 2014-12 PHASE1
NCT02533427 COMPLETED
HCV Infection
Gilead Sciences
 2015-10-29 PHASE1
NCT01308814 COMPLETED
Perimenopause; Menopause; Depression
University of North Carolina, Chapel Hill
 2010-10 PHASE2; PHASE3
NCT02480881 COMPLETED
Infection, Human Immunodeficiency Virus
ViiV Healthcare
 2015-07-07 PHASE1
NCT02333253 COMPLETED
Other Complications Associated With Artificial Fertilization
Cairo University
 2015-01 PHASE3
NCT02847806 COMPLETED
Hypogonadism
University Hospital, Caen
 2008-01 PHASE3
NCT02161614 COMPLETED
Flow-mediated Dilation Evaluation of the Brachial Artery
Federal University of Minas Gerais
 2014-02
NCT01165307 COMPLETED
Menorrhagia
Abimbola Famuyide
 2009-08 PHASE4
NCT02316249 WITHDRAWN
Atrophy of Vagina; Vaginal Ulceration; Vaginitis
Northwell Health
 2015-04 PHASE2
NCT00030147 COMPLETED
Perimenopausal Depression; Depression
National Institute of Mental Health (NIMH)
 2002-02 PHASE4
NCT01638923 COMPLETED
Metrorrhagia
Bayer
 2012-06 PHASE3
NCT01723579 WITHDRAWN
Contraception
Organon and Co
 2013-07 PHASE3
NCT00997893 COMPLETED
Menopause; Hot Flashes
University of Illinois at Chicago
 2009-12 PHASE2
NCT01586000 COMPLETED
Suppression of Ovulation
Kimberly Myer
 2012-03 PHASE2
NCT01480778 COMPLETED
Irregular Periods
Azidus Brasil
 2014-07 PHASE3
NCT02215395 COMPLETED
Antifungal Drug Adverse Reaction
Population Council
 2014-03 PHASE1
NCT01953809 WITHDRAWN
Infections, Bacterial
GlaxoSmithKline
 2014-08 PHASE1
NCT02027337 UNKNOWN
Polycystic Ovarian Syndrome; Hyperandrogenism; Menstrual Irregularities
Tyumen State Medical Academy
 2013-12 PHASE4
NCT02872818 COMPLETED
Apoptotic Signal Pathways in Endometrial Hyperplasia
Kayseri Education and Research Hospital
 2014-10 PHASE4
NCT02021097 UNKNOWN
Oral Contraceptive
Regenex Pharmaceutical, China
 2012-02 PHASE3
NCT01360996 COMPLETED
Polycystic Ovary Syndrome
Woman's
 2011-08 PHASE4
NCT01427595 COMPLETED
Polycystic Ovary Syndrome; Hyperandrogenism
University of Virginia
 2009-02-18
NCT01798836 TERMINATED
Infertility
National and Kapodistrian University of Athens
 2013-02 PHASE2; PHASE3
NCT01780610 UNKNOWN
Infertility
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
 2012-01
NCT01780558 UNKNOWN
Infertility
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
 2010-01
NCT01714128 WITHDRAWN
Breast Cancer
Washington University School of Medicine
 2013-06
NCT02195986 COMPLETED
Atrophic Vaginitis
Mylan Pharmaceuticals Inc
 2014-06 PHASE3
NCT02159131 COMPLETED
Infections, Human Immunodeficiency Virus and Hepatitis
ViiV Healthcare
 2014-08 PHASE1
NCT01810315 COMPLETED
HIV Prevention
CONRAD
 2013-09 PHASE1
NCT02157467 COMPLETED
Infection, Human Immunodeficiency Virus
ViiV Healthcare
 2014-06-02 PHASE1
NCT02080468 COMPLETED
Healthy
Aegerion Pharmaceuticals, Inc.
 2014-02-19 PHASE1
NCT01941615 TERMINATED
Healthy
Boehringer Ingelheim
 2013-11 PHASE1
NCT01065220 COMPLETED
Transsexualism
Medical University of Vienna
 2010-02 PHASE4
NCT01268046 COMPLETED
Memory Loss; Cognitive Changes; Postmenopausal Symptoms
Massachusetts General Hospital
 2009-11 PHASE1; PHASE2
NCT01805817 WITHDRAWN
Contraceptive Methods Comparison
Istanbul Training and Research Hospital
 2012-12 PHASE4
NCT02524561 COMPLETED
Mammographic Density; Abnormal Mammogram
Brigham and Women's Hospital
 2005-09
NCT01816139 COMPLETED
Vulvovaginal Atrophy
Warner Chilcott
 2013-01-31 PHASE3
NCT01441635 COMPLETED
Heavy Uterine Bleeding; Uterine Fibroids
AbbVie (prior sponsor, Abbott)
 2011-09-08 PHASE2
NCT01709318 COMPLETED
Contraception
Organon and Co
 2012-12-12 PHASE2
NCT03359057 COMPLETED
Contraception
Galeno Desenvolvimento de Pesquisas Clínicas
 2013-02-26 PHASE3
NCT01986764 WITHDRAWN
Planned RRSO
University of Pennsylvania
 2013-07-01
NCT01419353 COMPLETED
Infertility
Meir Medical Center
 2011-08 PHASE4
NCT01083641 TERMINATED
Female Breast Cancer
University of Wisconsin, Madison
 2010-01 PHASE2
NCT01023178 COMPLETED
Ovarian Failure, Premature
Stanford University
 2007-02
NCT01850095 UNKNOWN
Acne; Quality of Life
Marco Alexandre Dias da Rocha
 2012-03
NCT01753102 TERMINATED
Vulvar Atrophy; Vaginal Atrophy
Sun Pharmaceutical Industries Limited
 2012-11-06 PHASE3
NCT00114517 COMPLETED
Atherosclerosis
University of Southern California
 2004-07 PHASE2
NCT01254292 COMPLETED
Contraception
Bayer
 2011-01-06 PHASE3
NCT01418209 COMPLETED
Hot Flashes; Menopause; Vasomotor Disturbance
Fred Hutchinson Cancer Center
 2011-11
NCT01381016 COMPLETED
Obesity; Infertility
University of Colorado, Denver
 2011-06
NCT01615354 COMPLETED
Healthy Volunteer
Hoffmann-La Roche
 2012-07 PHASE1
NCT01490190 COMPLETED
Contraception
Organon and Co
 2011-12-26 PHASE4
NCT01310647 COMPLETED
Ovarian Diseases
Instituto de Investigacion Sanitaria La Fe
 2011-06 PHASE2
NCT00442689 COMPLETED
Polycystic Ovary Syndrome; Metabolic Syndrome
Northwestern University
 2006-07
NCT00608062 COMPLETED
Arterial Stiffening; Aging; Menopause
University of Colorado, Denver
 2007-03
NCT01251263 UNKNOWN
Menstrual Migraines; Menstrual Bleeding; Menstrual Spotting
Scott and White Hospital & Clinic
 2010-10 PHASE4
NCT01448291 UNKNOWN
Vaginosis, Bacterial
Eastern Virginia Medical School
 2011-10 PHASE4
NCT01257984 COMPLETED
Contraception
Bayer
 2010-12 PHASE3
NCT01569113 COMPLETED
Emergency Contraception
HRA Pharma
 2012-03 PHASE4
NCT01546454 COMPLETED
Coronary Heart Disease
Oregon Health and Science University
 2012-02
NCT01597986 COMPLETED
Pharmacokinetics of Isavuconazole; Pharmacokinetics of Ethinyl Estradiol and Norethindrone; Healthy Volunteers
Astellas Pharma Global Development, Inc.
 2012-04 PHASE1
NCT00154180 UNKNOWN
Menopause; Arteriosclerosis
Kronos Longevity Research Institute
 2005-09 PHASE4
NCT01501448 COMPLETED
Infertility
IVI Madrid
 2012-01 PHASE4
NCT01603745 UNKNOWN
Polycystic Ovary Syndrome
Catholic University of the Sacred Heart
 2012-04 PHASE1
NCT00722761 COMPLETED
Acne Vulgaris
Massachusetts General Hospital
 2009-04 PHASE3
NCT01291004 COMPLETED
Follicle Development; Ovarian Follicle; Follicle Count; Follicle Size; Oral Contraceptive
Teva Branded Pharmaceutical Products R&D, Inc.
 2011-01-31 PHASE1
NCT00193726 TERMINATED
Breast Cancer
Sudeep Gupta
 2005-07 PHASE3
NCT01498861 COMPLETED
Infection, Human Immunodeficiency Virus
ViiV Healthcare
 2011-12 PHASE1
NCT02467673 COMPLETED
Menopausal Syndrome
University Potiguar
 2012-01 PHASE2
NCT01109979 COMPLETED
Cardiovascular Diseases
Brigham and Women's Hospital
 2009-12 PHASE4
NCT00370019 WITHDRAWN
Premature Ovarian Failure
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
 2006-08-25 PHASE2
NCT00455962 COMPLETED
Premenopause; Healthy
Massachusetts General Hospital
 2005-01 PHASE1; PHASE2
NCT00722800 TERMINATED
Hidradenitis Suppurativa
Massachusetts General Hospital
 2008-10 PHASE2
NCT00357006 COMPLETED
Schizophrenia; Schizoaffective Disorder; Schizophreniform Disorder(Not in Manic Phase)
The Alfred
 2006-07 PHASE2
NCT00999479 WITHDRAWN
Endometrioma
University of Oklahoma
 2009-10
NCT01185704 COMPLETED
Polycystic Ovarian Syndrome
Merck KGaA, Darmstadt, Germany
 2008-11 PHASE3
NCT01221831 COMPLETED
Contraception
Estetra
 2010-09 PHASE2
NCT00914693 COMPLETED
Contraception
Bayer
 2009-04 PHASE3
NCT01581814 COMPLETED
Polycystic Ovary Syndrome
Catholic University of the Sacred Heart
 2008-10 PHASE3
NCT00755963 COMPLETED
Hormone Replacement
Medical University of Vienna
 2009-05 PHASE4
NCT01519401 COMPLETED
Polycystic Ovary Syndrome; Estro-progestin Drugs
Catholic University of the Sacred Heart
 2010-02
NCT01459445 UNKNOWN
Polycystic Ovary Syndrome; Endothelial Dysfunction
Iuliu Hatieganu University of Medicine and Pharmacy
 2011-02
NCT01056042 COMPLETED
Endometriosis
Prince of Songkla University
 2007-06 PHASE4
NCT00829114 COMPLETED
HIV/AIDS; HIV Infections
FHI 360
 2009-03 PHASE4
NCT00870220 TERMINATED
Turner's Syndrome
University of Chicago
 2009-04 PHASE1
NCT00324259 COMPLETED
Breast Neoplasms
Washington University School of Medicine
 2004-08 PHASE2
NCT01087879 COMPLETED
Contraception
University of Oulu
 2007-10
NCT00910637 COMPLETED
Contraception
Bayer
 2009-05-01 PHASE3
NCT01569945 COMPLETED
Subfertility
University Hospital, Gasthuisberg
 2004-09
NCT01103518 UNKNOWN
Amenorrhea; Dysmenorrhea; Menstruation Disturbances; Hyperandrogenism
Fundação Educacional Serra dos Órgãos
 2009-12 PHASE4
NCT01489852 COMPLETED
Infertility
Gemer
 2006-12 PHASE4
NCT00465894 COMPLETED
Overactive Bladder
University of Alabama at Birmingham
 2007-04
NCT00237042 COMPLETED
Temporomandibular Joint Disorders
University of Washington
 2005-10
NCT01063023 COMPLETED
Hepatitis C Virus
Bristol-Myers Squibb
 2010-01 PHASE1
NCT00089414 TERMINATED
Premenstrual Syndrome; PMS; Premenstrual Dysphoric Disorder; PMDD; Depression
National Institute of Mental Health (NIMH)
 2004-07 PHASE2
NCT00905723 UNKNOWN
Postmenopausal Symptoms
Federal University of São Paulo
 2009-05 PHASE3
NCT00576225 WITHDRAWN
NSCLC
CTI BioPharma
 2007-09 PHASE3
NCT00915915 COMPLETED
Contraception; Ovulation Inhibition
Bayer
 2009-06 PHASE2
NCT01466673 COMPLETED
Acne Vulgaris
Janssen-Cilag Ltd.,Thailand
 2008-12 PHASE4
NCT01600274 COMPLETED
Focus: Bioequivalence
Pharbil Waltrop GmbH
 2010-01
NCT00983957 COMPLETED
Chronic Hepatitis C
Bristol-Myers Squibb
 2009-10 PHASE1
NCT00701337 COMPLETED
Postmenopausal
University Hospital, Toulouse
 2006-09 PHASE4
NCT00789802 COMPLETED
Contraception; Bleeding
Washington University School of Medicine
 2008-11
NCT00569244 COMPLETED
Primary Dysmenorrhea
Bayer
 2007-12 PHASE3
NCT00567164 COMPLETED
Contraception; Ovulation Inhibition; Contraceptives, Oral
Bayer
 2007-10 PHASE3
NCT00915174 COMPLETED
Healthy
Merz Pharmaceuticals GmbH
 2009-06 PHASE1
NCT00785317 UNKNOWN
Hormone Replacement Therapy
Karolinska Institutet
 2008-11 PHASE4
NCT01668446 COMPLETED
Endometrial Preparation; Frozen Embryo Transfer
farzaneh hojjat
 2009-09 PHASE4
NCT00901290 SUSPENDED
Pharmacokinetics
AstraZeneca
 2009-05 PHASE1
NCT00522873 COMPLETED
Postmenopause
Bayer
 2007-08 PHASE3
NCT00653614 COMPLETED
Contraceptive, Oral, Hormonal
Bayer
 2008-03 PHASE2
NCT00511342 COMPLETED
Contraception
Organon and Co
 2006-09 PHASE3
NCT00145522 COMPLETED
Menopause
Solvay Pharmaceuticals
 2005-11 PHASE4
NCT00821496 COMPLETED
Healthy
VIVUS LLC
 2009-01 PHASE1
NCT01120665 COMPLETED
Women's Health
University of Sao Paulo General Hospital
 2002-02
NCT00537836 COMPLETED
Vasomotor System
Bayer
 2007-10 PHASE2
NCT00740194 COMPLETED
Healthy
University Hospital, Ghent
 2008-08 PHASE1; PHASE2
NCT01367912 COMPLETED
Infertility
Zekai Tahir Burak Women's Health Research and Education Hospital
 2008-02
NCT00685906 COMPLETED
Healthy
AstraZeneca
 2008-04 PHASE1
NCT00196313 COMPLETED
Dysmenorrhea
Duramed Research
 2005-05 PHASE2
NCT00266032 COMPLETED
Contraception
Bayer
 2005-12 PHASE3
NCT01344369 COMPLETED
Healthy
Teva Pharmaceuticals USA
 2008-08 PHASE1
NCT00468481 COMPLETED
Neural Tube Defects; Contraception; Oral Contraceptives (OC)
Bayer
 2007-04 PHASE3
NCT00090857 COMPLETED
Breast Cancer
Dana-Farber Cancer Institute
 2002-02 PHASE2
NCT00612508 COMPLETED
Contraceptive Usage; Vaginal Epithelial Disruption
Oregon Health and Science University
 2007-05
NCT00668603 COMPLETED
Postmenopausal Vasomotor Symptoms; Cardiovascular Disease
University of Helsinki
 2005-08
NCT00511433 COMPLETED
Contraception
Organon and Co
 2006-10 PHASE3
NCT01258660 COMPLETED
Contraception
Bayer
 2006-12 PHASE1
NCT00511355 COMPLETED
Contraception
Organon and Co
 2006-10 PHASE3
NCT00551733 TERMINATED
Lung Cancer
CTI BioPharma
 2007-08 PHASE3
NCT00471991 COMPLETED
Oral Contraceptive
Bayer
 2007-04 PHASE2
NCT00160316 COMPLETED
Postmenopause
Solvay Pharmaceuticals
 2005-04 PHASE3
NCT00191113 COMPLETED
Turner Syndrome
Eli Lilly and Company
 1989-02 PHASE3
NCT00356447 COMPLETED
Vasomotor Symptoms
Bayer
 2006-05 PHASE3
NCT00251082 COMPLETED
Postmenopause
Solvay Pharmaceuticals
 2005-12 PHASE3
NCT00711607 COMPLETED
Healthy
Organon and Co
 2007-05-01 PHASE1
NCT00593294 COMPLETED
Polycystic Ovary Syndrome
Federico II University
 2006-01 PHASE4
NCT00196365 COMPLETED
Dysmenorrhea
Duramed Research
 2005-01 PHASE3
NCT01253174 COMPLETED
Contraception
Bayer
 2006-08 PHASE1
NCT00113100 COMPLETED
Skin Wrinkling
University of Michigan
 2004-08
NCT00196326 COMPLETED
Contraception
Duramed Research
 2005-06 PHASE3
NCT00108849 COMPLETED
Menopause; Postmenopausal Vaginal Atrophy
Novo Nordisk A/S
 2005-03 PHASE3
NCT01508858 COMPLETED
Diabetes; Diabetes Mellitus, Type 2
Novo Nordisk A/S
 2006-11 PHASE1
NCT00269620 COMPLETED
Contraception
University of Pittsburgh
 2005-06 PHASE4
NCT00167648 COMPLETED
Cancer; Prostate Neoplasms
University of Washington
 2005-03 PHASE2
NCT00319163 COMPLETED
Healthy
Wyeth is now a wholly owned subsidiary of Pfizer
 2006-05 PHASE1
NCT00732693 COMPLETED
Premature Ovarian Failure
University of Edinburgh
 2002-02 PHASE4
NCT00185237 COMPLETED
Hot Flashes
Bayer
 2005-07 PHASE3
NCT01389102 COMPLETED
Hot Flashes
Lumara Health, Inc.
 2004-12 PHASE3
NCT00212277 COMPLETED
Dysmenorrhea
Nobelpharma
 2005-02 PHASE3
NCT01182194 COMPLETED
Healthy
Teva Pharmaceuticals USA
 2006-06 PHASE1
NCT00161681 COMPLETED
Premenstrual Syndrome
Wyeth is now a wholly owned subsidiary of Pfizer
 2005-07 PHASE3
NCT00236301 TERMINATED
Healthy Symptomatic Menopausal Women
Assistance Publique - Hôpitaux de Paris
 2004-03 PHASE3
NCT00662454 COMPLETED
Contraception; Body Weight
Oregon Health and Science University
 2006-01 PHASE4
NCT00212342 COMPLETED
Dysmenorrhea
Nobelpharma
 2004-12 PHASE3
NCT00413764 COMPLETED
Sexual Dysfunction
Organon and Co
 2004-03-23 PHASE3
NCT00000897 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
NCT01477632 COMPLETED
Menopause; Healthy
Novo Nordisk A/S
 2005-03 PHASE1
NCT00184795 COMPLETED
Menopause; Menopausal Vasomotor Symptoms
Novo Nordisk A/S
 2004-05-28 PHASE3
NCT00431093 COMPLETED
Menopause
Organon and Co
 2002-11 PHASE4
NCT00307632 COMPLETED
Contraception
Janssen-Cilag Farmaceutica Ltda.
 2003-02 PHASE4
NCT01044056 COMPLETED
Contraception
Organon and Co
 2004-03 PHASE4
NCT00805415 COMPLETED
Ovulation Inhibition
Bayer
 2003-03 PHASE2
NCT01070979 COMPLETED
Hormone Replacement Therapy
Warner Chilcott
 2003-02 PHASE3
NCT00650442 COMPLETED
Healthy
Mylan Pharmaceuticals Inc
 2003-01 PHASE1
NCT00860964 COMPLETED
Osteoporosis
Peking Union Medical College
 1998-02 PHASE4
NCT02245438 TERMINATED
Healthy
Boehringer Ingelheim
 2002-05 PHASE1
NCT02182791 COMPLETED
HIV Infections
Boehringer Ingelheim
 1998-04 PHASE1
NCT00465192 COMPLETED
Menopause; Postmenopausal Vaginal Atrophy
Novo Nordisk A/S
 1994-08-31 PHASE3
NCT00391417 COMPLETED
Hot Flashes
BioSante Pharmaceuticals
 2003-09 PHASE3
NCT00117273 COMPLETED
Healthy
Duramed Research
 2005-06 PHASE3
NCT00236769 COMPLETED
Contraception; Female Contraception
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
 1997-11 PHASE3
NCT00185224 COMPLETED
Contraception
Bayer
 2005-03 PHASE2
NCT00775086 COMPLETED
Female Contraception
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
 2004-05 PHASE1
NCT00102141 COMPLETED
Hypertension; Postmenopause
Bayer
 2004-04 PHASE3
NCT00294463 COMPLETED
Postmenopause; Osteoporosis
Erasmus Medical Center
 2003-02 PHASE4
NCT00206557 COMPLETED
Schizophrenia; Schizoaffective Disorder; Schizophreniform Disorder
The Alfred
 2002-10 PHASE2
NCT00004763 COMPLETED
Hyperandrogenism
National Center for Research Resources (NCRR)
 1993-01 PHASE2
NCT00003771 COMPLETED
Breast Cancer; Menopausal Symptoms
Regional Oncologic Center
 1997-09 PHASE3
NCT00435175 COMPLETED
Postmenopause
University of Aarhus
 2005-06
NCT00001221 COMPLETED
Gonadal Dysgenesis; Turner's Syndrome
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
 1987-09 PHASE2
NCT00236782 COMPLETED
Contraception
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
 1997-10 PHASE3
NCT00490308 UNKNOWN
Infertility
Assaf-Harofeh Medical Center
 2007-08 PHASE1
NCT00236795 COMPLETED
Contraception; Female Contraception
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
 1997-01 PHASE3
NCT00651469 COMPLETED
Acne Vulgaris
Bayer
 2003-01 PHASE3
NCT00709332 COMPLETED
Drug Interactions; Contraception; Pharmacokinetics
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
 2005-01 PHASE1
NCT00213096 COMPLETED
Contraception
Population Council
 2003-03 PHASE2
NCT00204438 COMPLETED
Contraception
University of Saskatchewan
 2002-02
NCT00005108 COMPLETED
Atherosclerosis; Healthy; Vascular Disease
National Heart, Lung, and Blood Institute (NHLBI)
 2000-04 PHASE2
NCT00195559 COMPLETED
Premenstrual Syndrome; Menstruation Disturbances
Wyeth is now a wholly owned subsidiary of Pfizer
 2005-09 PHASE3
NCT00361075 COMPLETED
Menopause; Postmenopause; Premenopause; Cardiovascular Disease
Northwestern University
 1998-07 PHASE4
NCT00320567 COMPLETED
Osteoporosis
McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.
 PHASE2
NCT00709189 COMPLETED
Female Contraception; Contraception; Therapeutic Equivalency; Pharmacokinetics
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
 2005-05 PHASE1
NCT00651599 COMPLETED
Vasomotor Symptoms
Bayer
 2004-07 PHASE3
NCT00367276 COMPLETED
Healthy
Bayer
 2002-12 PHASE3
NCT00653016 COMPLETED
Female Contraception
Janssen-Ortho Inc., Canada
 2002-10 PHASE4
NCT00428311 COMPLETED
Polycystic Ovary Syndrome
Hospital Universitario Ramon y Cajal
 2004-04 PHASE4
NCT00206622 COMPLETED
Hot Flashes
Bayer
 2004-12 PHASE4
NCT00185328 COMPLETED
Postmenopause
Bayer
 2005-09 PHASE4
NCT00026962 COMPLETED
Breast Cancer
National Cancer Institute (NCI)
 1999-09 PHASE2
NCT00709982 COMPLETED
Drug Interactions; Healthy; Pharmacokinetics
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
 2005-05 PHASE1
NCT00204074 UNKNOWN
Migraine
University Hospital, Linkoeping
 2001-10 PHASE2; PHASE3
NCT00006133 COMPLETED
Systemic Lupus Erythematosus
National Center for Research Resources (NCRR)
 2000-06
NCT00006324 COMPLETED
HIV Infections
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
 1999-12
NCT00220324 COMPLETED
Contraception
Bayer
 2004-02 PHASE3
NCT00310531 COMPLETED
Osteopenia
Bayer
 2004-02 PHASE3
NCT00044837 TERMINATED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
 PHASE1
NCT00350480 COMPLETED
Uterine Hemorrhage; Menorrhagia
Kaiser Permanente
 2003-04
NCT00463450 COMPLETED
Hormone Replacement Therapy
Bayer
 2002-05 PHASE3
NCT00258063 COMPLETED
Contraception; Female Contraception
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
 2004-05 PHASE1
NCT00344383 COMPLETED
Metrorrhagia
McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.
 2003-11 PHASE2

(data from https://clinicaltrials.gov, updated on 2026-06-17)

Check the Estradiol Benzoate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Estradiol benzoate functions as a potent estrogen receptor alpha agonist that selectively binds human, murine, and chicken estrogen receptor alpha with IC50 values ranging from 22 to 28 nM, thereby promoting receptor dimerization, nuclear translocation, and downstream activation of estrogen-responsive transcriptional pathways. This targeted signaling activation drives cellular proliferation, tissue differentiation, and mucosal restoration in estrogen-sensitive tissues, providing therapeutic efficacy across clinical trial indications such as atrophic vaginitis, contraception, and menopausal hormone therapy.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

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Note: Technical data last updated: Sep 1, 2026.