CAS No. 305-01-1

Batch: Purity:99.97
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Esculetin Chemical Structure
Chemical Structure
Check the Esculetin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 6,7-dihydroxychromen-2-one
CAS Number 305-01-1
Molecular Formula

C9H6O4
Molecular Weight (MW) 178.14
SMILES C1=CC(=O)OC2=CC(=C(C=C21)O)O
InChIKey ILEDWLMCKZNDJK-UHFFFAOYSA-N

Ordering Information

Biological Activity

Esculetin is a naturally occurring coumarin derivative that acts as a potent inhibitor of lipoxygenases, particularly 5-lipoxygenase (5-LOX). By blocking lipoxygenase activity, esculetin suppresses the biosynthesis of proinflammatory leukotrienes within the arachidonic acid metabolic pathway. Downstream, this inhibition attenuates NF-kB signaling, reduces oxidative stress, and decreases proinflammatory cytokine expression, thereby exerting anti-inflammatory, anti-edema, and anti-tumor effects in cellular models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 35 mg/mL (196.47 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.