Clinical Trials

Numerous clinical trials, ranging from early phase 1 through phase 4, evaluate the therapeutic applications and physiological effects of epinephrine hydrochloride across diverse indications, including septic shock, acute kidney injury, anaphylaxis, perioperative pain, intraocular procedures, and small cell lung cancer. Sponsored by prominent academic and healthcare institutions—such as Mansoura University, Assistance Publique - Hôpitaux de Paris, and Henry Ford Health System—these studies span active, recruiting, and completed recruitment statuses. This broad research landscape highlights the continuous evaluation of epinephrine hydrochloride across emergency, critical, and perioperative care.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT07785609 NOT_YET_RECRUITING
Advanced Solid Tumors; Malignant Neoplasm
Merck Sharp & Dohme LLC
 2026-09-30 PHASE2
NCT07392580 RECRUITING
Laryngeal Squamous Cell Carcinoma
University of Miami
 2026-12-01 PHASE2
NCT04964869 RECRUITING
Bleeding Hemorrhage
Wen-Hsin Huang
 2021-07-15
NCT07442071 NOT_YET_RECRUITING
Out-of-hospital Cardiac Arrest (OHCA)
Central Hospital, Nancy, France
 2026-06 PHASE3
NCT06473116 NOT_YET_RECRUITING
Out-Of-Hospital Cardiac Arrest
University of Southern Denmark
 2025-03 PHASE4
NCT07667829 NOT_YET_RECRUITING
Pulmonary Arterial Hypertension (PAH); Chronic Thromboembolic Pulmonary Hypertension (CTEPH); Hypertension, Pulmonary
China National Center for Cardiovascular Diseases
 2026-06
NCT06416969 RECRUITING
Obesity
Mayo Clinic
 2024-01-01 EARLY_PHASE1
NCT05166343 RECRUITING
Pediatric Out-of-Hospital Cardiac Arrest
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
 2024-01-08 PHASE2; PHASE3
NCT07144267 NOT_YET_RECRUITING
Cardiac Anaesthesia; Cardiopulmonary Bypass
Mansoura University
 2026-03-01
NCT03826524 RECRUITING
Cardiac Arrest, Out-Of-Hospital; Sudden Cardiac Arrest; Ventricular Fibrillation; Ventricular Tachycardia-Pulseless
Unity Health Toronto
 2023-05-24 PHASE4
NCT07092566 RECRUITING
Renal Carcinoma; Nephrectomy / Methods; Pain Management
Wake Forest University Health Sciences
 2025-11-14 PHASE3
NCT06471348 RECRUITING
Post Operative Pain; Spinal Fusion
Boston Children's Hospital
 2025-08-15
NCT07608900 NOT_YET_RECRUITING
Sevoflurane Consumption
TC Erciyes University
 2026-08
NCT07753629 NOT_YET_RECRUITING
Wide Excision; Postoperative Pain
Seoul National University Hospital
 2026-08-07
NCT07724418 NOT_YET_RECRUITING
This Study Will Focus on In-office Dermatological Procedures
Weill Medical College of Cornell University
 2026-08-01 PHASE4
NCT06927999 RECRUITING
Urticaria Chronic
ARS Pharmaceuticals, Inc.
 2025-07-09 PHASE2
NCT07468604 RECRUITING
Autonomic Dysfunction
University Health Network, Toronto
 2026-05-19 PHASE4
NCT07073209 RECRUITING
Hip Fractures
Weill Medical College of Cornell University
 2025-07-10
NCT06429501 RECRUITING
Pain Management
Washington University School of Medicine
 2024-04-02 PHASE2
NCT05029726 RECRUITING
Lumbar Spinal Stenosis; Lumbar Disc Herniation; Lumbar Spondylolisthesis; Lumbar Spondylosis; Lumbar Radiculopathy; Lumbar Spine Instability; Synovial Cyst; Degenerative Disc Disease; Degenerative Spondylolisthesis; Degenerative Intervertebral Discs
John O'Toole
 2022-02-01 PHASE4
NCT07342010 NOT_YET_RECRUITING
Anesthesia, Local; Hand Surgery; Foot Surgery; Walant Surgery
Centre Hospitalier Universitaire de Nīmes
 2026-02-01 PHASE4
NCT07706426 NOT_YET_RECRUITING
Post Spinal Anaesthesia Hypotension
Ain Shams University
 2026-07-09
NCT06447194 WITHDRAWN
Degenerative Lumbar Spinal Stenosis; Degenerative Disc Disease; Degenerative Spondylolisthesis; Degenerative Disease
University of Maryland, Baltimore
 2025-10-01 PHASE1; PHASE2
NCT04592744 ACTIVE_NOT_RECRUITING
Cirrhosis, Liver; End Stage Liver DIsease; Acute Kidney Injury; Liver Transplant; Complications
University of California, Los Angeles
 2022-04-08 PHASE4
NCT07604337 NOT_YET_RECRUITING
Emergence Delirium; Pediatric Dental General Anesthesia; Postoperative Recovery
seher orbay yasli
 2026-06
NCT07038746 RECRUITING
Hypersensitivity; Anaphylaxis
Dr. George Luciuk
 2025-08-25 PHASE1
NCT02118467 RECRUITING
Shock
University of Chicago
 2014-05-15 PHASE4
NCT07775001 ACTIVE_NOT_RECRUITING
Septic Shock
Nishtar Medical University
 2026-02-18
NCT07638254 RECRUITING
Pulpitis
Universidad Autonoma de San Luis Potosí
 2026-03-02
NCT06809998 RECRUITING
Total Knee Anthroplasty; Osteoarthritis(Primary); Osteoarthritis (OA) of the Knee; Bilateral Knee Osteoarthritis
Unity Health Toronto
 2025-01-24 PHASE1; PHASE2
NCT07714915 NOT_YET_RECRUITING
Dental Anxiety; Pain; Pulpal Diseases
Recep Tayyip Erdogan University Training and Research Hospital
 2026-08-12
NCT07213635 ACTIVE_NOT_RECRUITING
Opioid Use; Surgical Recovery; Vaginal Hysterectomy; Prolapse Pelvic; Postoperative Pain
University of North Carolina, Chapel Hill
 2025-10-20 PHASE4
NCT07066306 ACTIVE_NOT_RECRUITING
Dentofacial Deformities; Analgesia; Vomiting, Postoperative; Nausea, Postoperative
Bezmialem Vakif University
 2025-06-21
NCT07480889 COMPLETED
Hemodynamic (MAP) Stability
Cairo University
 2026-03-18 PHASE3
NCT07409896 RECRUITING
Anesthetic Efficacy
Armed Forces Institute of Dentistry, Pakistan
 2026-03-20
NCT06203847 RECRUITING
Cardiac Arrest; Out-Of-Hospital Cardiac Arrest; Emergency Medical Services
National Taiwan University Hospital
 2024-07-16
NCT07400146 NOT_YET_RECRUITING
Postoperative Pain; Shoulder Pain
Cedars-Sinai Medical Center
 2026-02 PHASE4
NCT06655454 RECRUITING
Pain Assessment; Quality of Life (QOL); Analgesic Use
New York University
 2024-11-01 PHASE2
NCT06057675 RECRUITING
Postoperative Bleeding; Skin Cancer Face
Vanderbilt University Medical Center
 2024-03-19 PHASE2
NCT07031206 NOT_YET_RECRUITING
Anxiety; Pain
The University of Texas Health Science Center, Houston
 2025-07-01 PHASE2
NCT06519955 RECRUITING
Hip Dysplasia
Michael C Willey
 2024-10-03 PHASE2; PHASE3
NCT06847568 RECRUITING
ST Segment Elevation Myocardial Infarction (STEMI); No Reflow Phenomenon
Ain Shams University
 2024-04-01 PHASE3
NCT07210320 COMPLETED
Food Allergy; Anaphylaxis; Food Hypersensitivity; Food Allergy Peanut
Insignis Therapeutics, Inc.
 2025-10-24 PHASE1
NCT07733167 RECRUITING
Intra-Prostatic Epinephrine Injection in Bipolar Transurethral Resection of Large Prostate
Benha University
 2025-03-20 PHASE3
NCT07200778 RECRUITING
Laparoscopic Myomectomy
Minia University
 2025-09-11
NCT07228325 ENROLLING_BY_INVITATION
Anaphylaxis; Allergy
Nasus Pharma
 2025-11-03 PHASE1; PHASE2
NCT07788261 COMPLETED
Dexamethasone; Lidocaine; Scalp Incision Infiltration; Craniotomy
Assiut University
 2024-12-01
NCT06842771 NOT_YET_RECRUITING
Laparoscopic Adnexal Surgery
University of Tennessee
 2025-03 PHASE4
NCT03970655 COMPLETED
Chronic Rhinosinusitis (Diagnosis)
University of Florida
 2019-09-25 PHASE1; PHASE2
NCT05978687 COMPLETED
Pterygium
Vrije Universiteit Brussel
 2023-09-01 PHASE4
NCT06450028 COMPLETED
Pain, Postoperative; Numbness; Temperature Sensation; Perception of Touch
Boston Children's Hospital
 2024-10-01 PHASE4
NCT06112548 COMPLETED
Arthritis Knee; Pain; Arthroplasty Complications
Damascus University
 2024-03-01
NCT05972681 TERMINATED
Vaginal Laceration During Delivery
Montefiore Medical Center
 2025-04-08 PHASE4
NCT07667725 COMPLETED
Dental Anxiety; Inferior Alveolar Nerve; Pain Management
Al-Mustansiriyah University
 2025-02-01
NCT02692313 COMPLETED
Diabetes Complications
University of Maryland, Baltimore
 2016-06 EARLY_PHASE1
NCT06264596 WITHDRAWN
Intraoperative Bleeding
The Guthrie Clinic
 2024-08 PHASE3
NCT07120594 COMPLETED
Inflamed and Infected Primary Molars in Children; Effectiveness of Buffered Local Anesthesia During Dental Extraction
Latakia University
 2023-11-08
NCT06963411 COMPLETED
Acute Allergic Reaction; Anaphylaxis
Kokua Pharma Inc.
 2025-05-09 PHASE1
NCT06379490 COMPLETED
Distal Radius Fractures; Lidocaine; Ropivacaine; Fracture Dislocation; Closed Reduction of Fracture and Application of Plaster Cast; Colles' Fracture
Nordsjaellands Hospital
 2024-04-23 PHASE3
NCT05327556 TERMINATED
Hypotension
Boston Children's Hospital
 2023-02-08 PHASE2
NCT06566352 UNKNOWN
Different Methods to Minimize Blood Loss During Laparoscopic Myomectomy
Zagazig University
 2024-05-01
NCT07771452 COMPLETED
Procedural Pain
Herat University
 2025-03-02
NCT06445374 COMPLETED
Hypersensitivity; Anaphylaxis
Dr. George Luciuk
 2024-07-15 PHASE1
NCT07173179 COMPLETED
Post-ERCP Acute Pancreatitis
Duzce University
 2023-01-01 PHASE4
NCT06927726 ENROLLING_BY_INVITATION
Hypertension
Tanta University
 2025-01-10
NCT05688020 UNKNOWN
Gastric Polyp; Gastric Neoplasm; Duodenal Neoplasms; Esophageal Neoplasms
Assaf-Harofeh Medical Center
 2023-02-01 PHASE4
NCT06270147 RECRUITING
Opioid Use; Pain, Postoperative
McMaster University
 2024-11-21 PHASE2
NCT06040840 COMPLETED
Carpal Tunnel Syndrome
CMC Ambroise Paré
 2024-05-13
NCT03567473 COMPLETED
Bronchiolitis
Children's Hospital of Eastern Ontario
 2018-12-13 PHASE3
NCT04427904 UNKNOWN
Postoperative Pain; Thyroid Diseases; Anesthesia, Local
St. Joseph's Healthcare Hamilton
 2022-06-01 PHASE2
NCT06564987 UNKNOWN
Inferior Alveolar Nerve Injuries
Cleveland Dental Institute
 2024-01-01 PHASE1
NCT05488847 ACTIVE_NOT_RECRUITING
Shoulder Arthropathy; Shoulder Pain
Henry Ford Health System
 2022-06-25 PHASE4
NCT03913845 COMPLETED
Stress Urinary Incontinence
West Penn Allegheny Health System
 2019-11-25 PHASE4
NCT05908851 UNKNOWN
Shoulder Arthritis; Anesthesia, Local; Local Infiltration
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
 2023-11-01
NCT06381622 COMPLETED
Nerve Block; Anesthesia, Local; Forearm Fracture; Surgery; Brachial Plexus Block
Nordsjaellands Hospital
 2024-04-18 PHASE3
NCT06527937 COMPLETED
Allergic Reaction
Aquestive Therapeutics
 2024-07-17 PHASE2
NCT05492968 UNKNOWN
Cardiac Output, Low; Cardiac Output, High; Perfusion; Complications
Medical University of Vienna
 2022-09-01 PHASE4
NCT05313256 COMPLETED
Obstetric Labor Complications
University Hospital, Bordeaux
 2022-07-14 PHASE2; PHASE3
NCT06302998 Not yet recruiting
Sepsis|Septic Shock
Mansoura University
 2024-06 Phase 2
NCT07013071 COMPLETED
Hemodynamics; Pain; ASA I-II Requiring Simple Dental Extraction of a Mandibular Tooth
King Abdulaziz University
 2024-02-10 PHASE4
NCT06344442 Not yet recruiting
Acute Kidney Injury Post Liver Transplantation
Assistance Publique - Hôpitaux de Paris
 2024-05-05 Phase 3
NCT05188053 COMPLETED
Total Knee Arthroplasty
Mayo Clinic
 2022-03-11 PHASE4
NCT05728151 COMPLETED
Pediatric Squint Surgeries
Research Institute of Ophthalmology, Egypt
 2022-02-22
NCT06381479 Recruiting
Stress|Sleep Disorder
National Taiwan Sport University|Bened Biomedical Co. Ltd.
 2024-04-19 Not Applicable
NCT06334653 Not yet recruiting
Healthy Volunteers Only|Energy Metabolism
Helga Ellingsgaard|Rigshospitalet Denmark
 2024-04-09 Not Applicable
NCT05406895 COMPLETED
Inferior Alveolar Nerve; Mandibular Nerve Blocks
Louisiana State University Health Sciences Center in New Orleans
 2022-05-25
NCT05496465 COMPLETED
Urticaria
ARS Pharmaceuticals, Inc.
 2022-07-28 PHASE2
NCT06128590 COMPLETED
Fear Needles
University of Nove de Julho
 2023-02-15
NCT03476642 COMPLETED
Distribution of Ropivacaine in Erector Spinae Plane Block
Milton S. Hershey Medical Center
 2019-07-02 PHASE4
NCT06648265 COMPLETED
Liposuction; Bruising; Inflammation; Skin Condition; Edema Arm; Ecchymosis; Hematoma
Total Definer Research Group
 2022-01-20 PHASE4
NCT05260008 TERMINATED
Acute Postoperative Pain
Allay Therapeutics, Inc.
 2022-06-07 PHASE2
NCT05353062 UNKNOWN
Gastrointestinal Hemorrhage
Theresienkrankenhaus und St. Hedwig-Klinik GmbH
 2023-01-01
NCT06013150 COMPLETED
Anaphylactic Reaction
De Motu Cordis
 2023-10-24 PHASE1
NCT05374499 COMPLETED
Post Operative Pain
University of Southern California
 2022-09-01 PHASE4
NCT05881915 COMPLETED
Hypotension During Surgery
Cairo University
 2023-06-01
NCT06115473 UNKNOWN
Shock
Ain Shams University
 2023-08-01
NCT04959123 COMPLETED
Bowel Disease
Centre Hospitalier Universitaire de Nice
 2021-12-06
NCT05806307 UNKNOWN
Misoprostol Allergy; Oxytocin Allergy; Tranexamic Acid Allergy; Ethamsylate Allergy; Myoma; Blood Loss, Surgical
Cairo University
 2023-03-15 PHASE4
NCT05822765 COMPLETED
Intraoperative Hemodynamics; Liposuction
Al-Azhar University
 2023-05-01 PHASE3
NCT05407259 UNKNOWN
Healthy Young Adults
National Taiwan Normal University
 2022-06-01
NCT04198662 COMPLETED
Traumatic Rib Fracture(s)
University of California, San Diego
 2020-04-03 PHASE4
NCT05767749 COMPLETED
Anesthetics, Local
Weill Medical College of Cornell University
 2023-03-14 PHASE4
NCT05944341 UNKNOWN
Dental Pulp Diseases
Minia University
 2023-06-01
NCT04814433 TERMINATED
Opioid Pain Medication
NYU Langone Health
 2021-03-24 PHASE4
NCT05670808 UNKNOWN
To Determine the Optimal Doses of Adrenaline in Preventing Blood Loos in Participants Undergoing Supraclavicular Flap Surgery
Dow University of Health Sciences
 2023-02-01 PHASE1
NCT05507476 COMPLETED
Anesthesia
Zagazig University
 2022-09-01
NCT06862570 COMPLETED
Symptomatic Irreversible Pulpitis
28 Military Dental Centre Lahore
 2022-12-19 PHASE2
NCT05624957 COMPLETED
Postoperative Pain; Analgesia
Minia University
 2022-11-25
NCT04717193 COMPLETED
Appendicitis Acute
University of Alberta
 2021-05-28 PHASE2
NCT06293807 COMPLETED
Periodontal Diseases
The University of Texas Health Science Center at San Antonio
 2022-06-06 EARLY_PHASE1
NCT04603911 COMPLETED
Breast Cancer
Tufts Medical Center
 2020-12-04 PHASE2
NCT05294640 COMPLETED
Eyelid Tumor; Eyelid Bump; Eyelid Deformity; Eyelid Abscess; Eyelid Boil; Eyelid Papilloma; Anesthesia, Local; Ophthalmology
University of California, San Francisco
 2022-05-17 PHASE4
NCT01059786 ACTIVE_NOT_RECRUITING
Hairy Cell Leukemia
National Cancer Institute (NCI)
 2010-07-01 PHASE2
NCT07318311 COMPLETED
Comparative Evaluation of the Effect of pH Adjustment of the Solution of Articaine With Epinephrine on the Efficacy of Jet Anesthesia
Aristotle University Of Thessaloniki
 2022-08-01
NCT03119038 WITHDRAWN
Osteoarthritis; Degenerative Joint Disease
Rush University Medical Center
 2016-04-30 PHASE4
NCT03236324 COMPLETED
Cesarean Delivery
University of Calgary
 2017-09-22 PHASE2
NCT05101785 UNKNOWN
Pain; Behavior
Mahmoud Ahmed Mahmoud
 2021-11-01
NCT05244525 COMPLETED
Shoulder Arthroscopy
The University of Texas Health Science Center, Houston
 2022-03-14 PHASE4
NCT04186299 WITHDRAWN
Symptomatic Irreversible Pulpitis
University of California, San Francisco
 2021-08 PHASE4
NCT05279703 UNKNOWN
Postspinal Hypotension; Cesarean Delivery; Epinephrine
Kasr El Aini Hospital
 2022-03-21 PHASE4
NCT05427903 UNKNOWN
Pain, Procedural
Minia University
 2022-03-04
NCT04917055 TERMINATED
Knee Osteoarthritis; Acute Pain; Anesthesia, Local; Regional Anesthesia
University of California, San Diego
 2021-06-07 PHASE4
NCT05152901 COMPLETED
Anaphylactic Reaction
De Motu Cordis
 2022-01-06 PHASE1
NCT03554473 COMPLETED
Carcinoma, Small Cell; Lung Cancer; Small Cell Lung Cancer
National Cancer Institute (NCI)
 2018-09-11 PHASE1; PHASE2
NCT04991597 WITHDRAWN
Pain
Nicholas Bastidas
 2022-01-01
NCT05227300 COMPLETED
Symptomatic Irreversible Pulpitis
Indiana University
 2022-02-14 PHASE4
NCT03672500 TERMINATED
Second Degree Perineal Tear During Delivery - Delivered; Episiotomy; Complications; Anesthesia, Local
Sunnybrook Health Sciences Centre
 2018-09-14
NCT05738564 COMPLETED
Nasal Bleeding
Ain Shams University
 2021-09-01 PHASE3
NCT02980835 COMPLETED
Video-Assisted Thoracic Surgery; Video-Assisted Thoracoscopic Surgery
University at Buffalo
 2016-09-28 PHASE4
NCT05324995 COMPLETED
Postoperative Pain; Total Knee Arthroplasty
Isfahan University of Medical Sciences
 2021-01-01 PHASE2
NCT05672394 COMPLETED
Lung Cancer; Acute Pain; Chronic Pain
National Cancer Institute, Egypt
 2021-06-01
NCT05413902 COMPLETED
Pain Management; Posterior Spinal Fusion
University of Puerto Rico
 2021-04-05 PHASE4
NCT03071601 COMPLETED
Pain, Acute; Laceration
Centre Hospitalier le Mans
 2017-12-01 PHASE4
NCT04282239 WITHDRAWN
Pain, Postoperative; Cardiac Surgery
NYU Langone Health
 2021-03-01
NCT04594408 COMPLETED
Rotator Cuff Injuries; Rotator Cuff Tears; Subacromial Impingement; Subacromial Impingement Syndrome
Panam Clinic
 2020-09-01 PHASE4
NCT04696822 COMPLETED
Anaphylaxis
Nasus Pharma
 2020-11-01 PHASE1
NCT03814954 COMPLETED
Respiratory Distress Score
Makassed General Hospital
 2019-01-01
NCT05225597 COMPLETED
Epinephrine Toxicity; Cataract; Carbachol Adverse Reaction; Choroid Disease
Ordu University
 2021-01-01
NCT05361291 COMPLETED
Pulpitis - Irreversible
Jamia Millia Islamia
 2020-02-01
NCT04065451 COMPLETED
Colonic Polyp
Indiana University
 2020-01-06 PHASE4
NCT04799184 COMPLETED
Anesthetics Complications; Anesthetic Toxicity; Bupivacaine Overdose; Nerve Block; Surgery
Pontificia Universidad Catolica de Chile
 2019-04-03 PHASE4
NCT04380298 UNKNOWN
Pain; Supratentorial Brain Tumor
Beijing Tiantan Hospital
 2020-12-01 PHASE4
NCT03902782 COMPLETED
Lung Cancer; Lung Diseases
McGill University Health Centre/Research Institute of the McGill University Health Centre
 2019-06-26
NCT04733781 UNKNOWN
Venomous Snakebites; Local Anesthesia; Painless Injection; Regional Anesthesia; Dermatologic Surgery; Cutaneous Pain; Musculoskeletal Pain
Jeffrey Alan Klein, MD
 2021-02-22 PHASE2; PHASE3
NCT04369950 COMPLETED
Physiological Effect of Drugs; Morphine; Analgesics; Analgesics, Opioid; Central Nervous System Depressants; Narcotics
The University of Texas Health Science Center, Houston
 2020-05-11 PHASE4
NCT02886468 COMPLETED
Anaphylactic Shock
Centre Hospitalier Régional Metz-Thionville
 2016-08-26
NCT02570503 TERMINATED
Osteoarthritis, Knee
Virginia Commonwealth University
 2015-10 PHASE4
NCT03873480 COMPLETED
Trigger Thumb
Children's Hospital of Philadelphia
 2018-10-02
NCT04065919 UNKNOWN
Cardiothoracic Surgery
Florida Heart and Lung Institute
 2019-10-01 PHASE4
NCT03756116 UNKNOWN
Post-ERCP Acute Pancreatitis; Epinephrine
The Second Hospital of Nanjing Medical University
 2018-10-01
NCT03730714 COMPLETED
Postoperative Pain
Assiut University
 2018-11-15 PHASE2; PHASE3
NCT03317197 UNKNOWN
Cardiac Arrest
Korea University Guro Hospital
 2018-01-01 PHASE4
NCT02276495 COMPLETED
Pain Management
University of California, Irvine
 2015-01-01
NCT02740127 COMPLETED
Malignant Neoplasms of Male Genital Organs
M.D. Anderson Cancer Center
 2016-06 PHASE3
NCT04188184 COMPLETED
Intraoperative Bleeding
Assiut University
 2019-12-04
NCT02352155 TERMINATED
Ulcer Bleeding
Chinese University of Hong Kong
 2015-02-04
NCT03070054 COMPLETED
Pain
University of Utah
 2016-06 EARLY_PHASE1
NCT04378283 COMPLETED
Skin Lacerations
Universitätsklinikum Hamburg-Eppendorf
 2016-05
NCT04166890 COMPLETED
Drug Effect; Tooth Extraction
Universidad de Antioquia
 2018-09-04 PHASE4
NCT04522297 COMPLETED
Hepato-Renal Syndrome
National Hepatology & Tropical Medicine Research Institute
 2018-04-15
NCT04061265 COMPLETED
Behaviour Assessment; Pain
Minia University
 2019-08-25 PHASE1; PHASE2
NCT02986347 COMPLETED
Carpal Tunnel Syndrome; Anesthesia
Hospital Alvorada
 2017-05-27
NCT04628676 COMPLETED
Rotator Cuff Tears
Haseki Training and Research Hospital
 2017-02-01
NCT03427502 COMPLETED
Postoperative Agitation: Impaired Awareness, Abnormal Cognitive Function, Confusion, and Verbal and Physical Agitation During Recovery From General Anesthesia; Deviated Nasal Septum; Chronic Rhinosinusitis (Diagnosis); Nasal Polyps
Lumbini Medical College
 2018-06-01
NCT03335293 WITHDRAWN
Pregnancy; Cesarean Section
University of Florida
 2019-10 PHASE4
NCT04688346 COMPLETED
Epinephrine Causing Adverse Effects in Therapeutic Use
University of Washington
 2019-06-10 PHASE2; PHASE3
NCT04203225 COMPLETED
Lacerations; Pain, Procedural; LET
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
 2017-05-22 PHASE4
NCT04536493 COMPLETED
LET; Laceration of Skin
Children's Hospital of Orange County
 2019-06-19 PHASE4
NCT03094481 UNKNOWN
Clavicle Fracture
Sunnybrook Health Sciences Centre
 2016-10-21
NCT03723447 COMPLETED
Pain, Postoperative; Crohn Disease; Inflammatory Bowel Diseases; Colorectal Cancer; Gastrointestinal Cancer; Gastrointestinal Disease; Digestive System Disease; Pain; Pain, Neuropathic; Intestinal Disease
Cedars-Sinai Medical Center
 2018-10-23 PHASE4
NCT03661996 COMPLETED
Knee Osteoarthritis
Centrexion Therapeutics
 2018-09-18 PHASE3
NCT04947267 COMPLETED
LOCAL ANESTHESIA
Afshan Amjad Ali
 2018-05-30 PHASE2
NCT03880409 COMPLETED
Overcoming the Failure of Anesthesia in the Mandibular Teeth
Taibah University
 2019-02-09 PHASE1
NCT03839134 COMPLETED
Anesthetics, Local
Riyadh Colleges of Dentistry and Pharmacy
 2019-03-20
NCT03733171 UNKNOWN
Bleeding Ulcer
Zagazig University
 2018-09-20
NCT02959112 TERMINATED
Pancreatitis, Acute
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
 2016-05
NCT02315573 COMPLETED
Carpal Tunnel Syndrome
St. Mary's Research Center, Canada
 2014-10
NCT03638726 UNKNOWN
Cataract; Mydriasis; Adverse Drug Event
Dar El Oyoun Hospital
 2018-09-28 PHASE4
NCT03057015 UNKNOWN
Postoperative Pain
University of Vermont
 2017-05-22 PHASE4
NCT03862404 COMPLETED
Post Thoracic Surgery
McGill University Health Centre/Research Institute of the McGill University Health Centre
 2017-07-01 PHASE4
NCT02473263 COMPLETED
Severe Septic Syndrome (Severe Sepsis and Septic Shock) Diagnosed and Treated by Mobile Intensive Care Unit
Assistance Publique - Hôpitaux de Paris
 2016-05-09 PHASE3
NCT02534571 COMPLETED
Acute Upper Gastrointestinal Bleeding
Chinese University of Hong Kong
 2015-09-07 PHASE3
NCT02895035 TERMINATED
Cataract
Milton S. Hershey Medical Center
 2016-09-01 PHASE4
NCT03704909 COMPLETED
Hypotension
Ben marzouk Sofiene
 2018-09-01 PHASE4
NCT03595514 UNKNOWN
Upper Extremity Injury
McGill University Health Centre/Research Institute of the McGill University Health Centre
 2018-07-30
NCT03443726 COMPLETED
Tooth Extraction; Dental Anesthesia
University of Barcelona
 2017-06-10
NCT03282929 COMPLETED
Anaphylaxis
Bausch & Lomb Incorporated
 2017-03-23 PHASE1
NCT03399435 TERMINATED
Anesthesia; Anesthesia, Local; Analgesia
Grünenthal GmbH
 2018-01-30 PHASE1
NCT03576508 COMPLETED
Knee Osteoarthritis
Centrexion Therapeutics
 2018-06-25 PHASE1
NCT04102267 COMPLETED
Analgesia
Heron Therapeutics
 2018-07-02 PHASE4
NCT03439787 TERMINATED
Pain, Postoperative
University of Aarhus
 2018-05-15 PHASE4
NCT02627846 COMPLETED
Varicose Veins
Hull University Teaching Hospitals NHS Trust
 2015-06-01 PHASE4
NCT01664507 UNKNOWN
Croup; Epinephrine, Administration, Inhalation
Seoul National University Hospital
 2016-01 PHASE4
NCT00890162 COMPLETED
Anaphylaxis; Hypotension; Bronchospasm; Angioedema
National Institute of Allergy and Infectious Diseases (NIAID)
 2009-04-27 PHASE2
NCT05204056 COMPLETED
Pain, Postoperative; Blood Loss, Postoperative
Yantai Yuhuangding Hospital
 2018-03-02
NCT03094663 COMPLETED
Knee Arthropathy
Hospital for Special Surgery, New York
 2017-02-28 PHASE4
NCT03415724 UNKNOWN
Irreversible Pulpitis
Postgraduate Institute of Dental Sciences Rohtak
 2018-02-01
NCT03163914 COMPLETED
Spinal Anesthesia
Cukurova University
 2017-07-19 PHASE4
NCT03953001 COMPLETED
Local Anaesthetic; Dental Anxiety
Imam Abdulrahman Bin Faisal University
 2018-01-01
NCT03040167 COMPLETED
Pain, Postoperative; Anesthesia; Regional
Pierre Beaulieu
 2017-10-01 PHASE4
NCT03470532 COMPLETED
Pain
Melaka Manipal Medical College
 2017-02-25 PHASE4
NCT03007966 COMPLETED
Nerve Block; Herniorrhaphy; Regional Anesthesia
Wake Forest University Health Sciences
 2017-01-30 PHASE2
NCT03011333 COMPLETED
Postoperative Pain
Heron Therapeutics
 2017-01-14 PHASE2
NCT02726620 COMPLETED
Hypotension
Vanderbilt University Medical Center
 2017-01-05
NCT03036085 UNKNOWN
Pain, Postoperative; Thoracic Diseases; Local Anesthetics Causing Adverse Effects in Therapeutic Use; Opioid Dependence
Massachusetts General Hospital
 2017-02 PHASE2; PHASE3
NCT02540070 UNKNOWN
Osteoarthritis; Knee Arthroplasty; Pain Management
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
 2014-08 PHASE3
NCT02658240 COMPLETED
Postoperative Pain
University of Texas Southwestern Medical Center
 2016-04-05
NCT03319563 COMPLETED
Posterior Spine Surgery
Mansoura University
 2017-04-11
NCT02864095 UNKNOWN
Blood Loss
Southwest Hospital, China
 2015-05
NCT02462148 COMPLETED
Osteoarthritis, Knee
Wake Forest University Health Sciences
 2015-07 PHASE4
NCT02741232 COMPLETED
Nerve Block; Mastectomy
Maisonneuve-Rosemont Hospital
 2016-03
NCT03531970 COMPLETED
Local Anesthesia
Isfahan University of Medical Sciences
 2016-08-01 PHASE2; PHASE3
NCT03025594 UNKNOWN
Knee Arthroplasty; Pain Management
maximiliano barahona vasquez
 2017-01 PHASE3
NCT02854969 COMPLETED
Anaphylaxis
Adan Medical Innovation, SL
 2016-05
NCT02537353 UNKNOWN
Upper Gastrointestinal Bleeding
University of Sao Paulo General Hospital
 2015-09 PHASE4
NCT02365961 COMPLETED
Hip Dysplasia; Femoroacetabular Impingement; Acetabular Labrum Tear
The Hawkins Foundation
 2015-04 PHASE4
NCT02426164 WITHDRAWN
Pain, Postoperative; Arthroplasty, Replacement, Knee; Osteoarthritis
Miller Orthopedic Specialists
 2015-06 PHASE4
NCT02519023 COMPLETED
Acute Pain
University of Minnesota
 2016-07 PHASE4
NCT03034382 UNKNOWN
Rotator Cuff Tear
Assiut University
 2016-01 PHASE2
NCT02538679 COMPLETED
Crohn's Disease; Inflammatory Bowel Disease; Postoperative Pain
Cedars-Sinai Medical Center
 2015-08-07
NCT02585531 UNKNOWN
Bronchiolitis
Hospital General Naval de Alta Especialidad - Escuela Medico Naval
 2015-11 PHASE2
NCT02765815 WITHDRAWN
Osteoarthritis, Knee; Arthroplasty, Replacement, Knee
Holy Cross Hospital, Florida
 2016-02 PHASE4
NCT02285634 COMPLETED
Epistaxis; Blood Pressure
Mayo Clinic
 2014-11
NCT02116309 COMPLETED
Post-ERCP Acute Pancreatitis
Johns Hopkins University
 2014-08
NCT02525718 COMPLETED
Breast Cancer
Northwestern University
 2015-08 PHASE2
NCT02228083 UNKNOWN
Heart Failure
University of Sao Paulo General Hospital
 2014-09
NCT02659501 TERMINATED
Breast Cancer; Postoperative Pain
Loma Linda University
 2015-07
NCT01350024 COMPLETED
Blepharoptosis
University of Miami
 2011-05-01
NCT02526199 COMPLETED
Postoperative Pain
Rasmus Wulff Hauritz
 2015-08 PHASE4
NCT02422823 COMPLETED
Pulpitis
Isabel Peixoto Tortamano
 2015-04
NCT02417493 COMPLETED
Food Allergy
Icahn School of Medicine at Mount Sinai
 2015-03
NCT04758728 COMPLETED
Venous Insufficiency (Chronic)(Peripheral); Venous Reflux; Venous Insufficiency of Leg; Venous Stasis; Venous Disease; Subcutaneous Haematoma; Ecchymosis; Bruising
Junior Doctors Network-Hellas
 2015-09-10
NCT01583166 COMPLETED
Stress Urinary Incontinence
University of Massachusetts, Worcester
 2012-03
NCT02369510 COMPLETED
Spinal Anesthesia; Cesarean Section
Icahn School of Medicine at Mount Sinai
 2015-02 PHASE4
NCT03597945 COMPLETED
Acute Pain Due to Trauma
Faculty of Medicine, Sousse
 2015-04-30
NCT02718976 COMPLETED
Hip Fractures; Anesthesia, Local; Pain, Postoperative
University of Aarhus
 2016-03 PHASE2
NCT03001453 COMPLETED
Pain, Postoperative
American Hip Institute
 2014-04 PHASE2
NCT07018115 COMPLETED
Dental Anxiety; Hemodynamic; Molar, Third; Tooth Extraction; Tooth Impacted
Ummugulsum Coskun
 2015-06-01
NCT01883232 WITHDRAWN
Pediatric Dentistry
University of Colorado, Denver
 2013-08
NCT01367743 COMPLETED
Cardiogenic Shock
Central Hospital, Nancy, France
 2011-09 PHASE4
NCT02701582 COMPLETED
Intracranial Aneurysm; Brain Edema; Scoliosis; Surgery
NYU Langone Health
 2014-03
NCT02593370 COMPLETED
Hip Fractures; Anesthesia Local; Pain, Perioperative
Thomas F. Bendtsen
 2015-10 PHASE1
NCT02505633 COMPLETED
Radius Fractures
Gachon University Gil Medical Center
 2015-07
NCT02609295 COMPLETED
Hypercholesterolemia
Yonsei University
 2015-02 PHASE3
NCT02059694 WITHDRAWN
Upper Eyelid Surgery
Duke University
NCT02603198 UNKNOWN
Pain; Trismus; Edema
University of Sao Paulo
 2014-08
NCT01700192 COMPLETED
Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Nonseasonal
ALK-Abelló A/S
 2013-01 PHASE3
NCT02735018 COMPLETED
Cardiovascular Response to Epinephrine
Rio de Janeiro State University
 2014-12 PHASE4
NCT02752308 COMPLETED
Hypospadias
Isfahan University of Medical Sciences
 2014-09 PHASE2; PHASE3
NCT02628522 COMPLETED
Anal Fissure
Clinical Centre of Serbia
 2014-12
NCT02268019 UNKNOWN
Hypospadias Repair
Isfahan University of Medical Sciences
 2013-01
NCT01533545 TERMINATED
Renal Insufficiency, Chronic
Rigshospitalet, Denmark
 2012-09
NCT02701296 COMPLETED
Posterior Knee Infiltration
Trinity Health Of New England
 2011-11-07
NCT02230735 WITHDRAWN
Pain
Souza, Amanda, M.D.
 2014-08
NCT01602692 COMPLETED
Pain, Postoperative; Postoperative Nausea and Vomiting
University of Wisconsin, Madison
 2012-08 PHASE4
NCT02007434 COMPLETED
Moderate or Severe Submental Fullness
Kythera Biopharmaceuticals
 2013-12 PHASE3
NCT01982929 COMPLETED
Reduction in Post Ceasarean-section Related Pain in Study Group (TAP Block)
Vicki Modest, MD
 2013-11
NCT02020603 COMPLETED
Active Peptic Ulcer Disease/GI Bleeding
Kyunghee University Medical Center
 2012-01
NCT04153123 COMPLETED
Ophthalmic Artery; Peribulbar Block
Federal University of Minas Gerais
 2013-12-01
NCT01862614 COMPLETED
Anesthetic Effectiveness
Ohio State University
 2013-04 PHASE4
NCT01786655 COMPLETED
Safety of Neosaxitoxin in Healthy Volunteers
Charles Berde
 2013-05 PHASE1
NCT01861015 COMPLETED
Uterine Myomas
CHA University
 2013-05 PHASE3
NCT02359136 COMPLETED
Osteoarthritis, Hip
St. Olavs Hospital
 2013-03
NCT01304212 COMPLETED
Pain
Jose Antonio Bernia Gil
 2011-04 PHASE4
NCT01829399 COMPLETED
Application Site Discomfort; Medical Device Discomfort
University of North Carolina, Chapel Hill
 2013-04 PHASE4
NCT01043211 WITHDRAWN
Back Pain
University of Alabama at Birmingham
 2012-01
NCT02226913 COMPLETED
Local Anesthesia
Masoud Saatchi
 2013-02 PHASE3
NCT01560702 COMPLETED
Blood, Injection, Injury Type Phobia; Gastrointestinal Ulcer Haemorrhage; Adverse Reaction to Epinephrine
Zagazig University
 2012-03
NCT02154048 TERMINATED
Surgery, Hand
Duke University
 2012-04 PHASE2
NCT03163472 COMPLETED
Brachial Plexus Blockade
Cork University Hospital
 2012-11-14
NCT01574807 COMPLETED
Pain
Ohio State University
 2012-05 PHASE4
NCT01606969 COMPLETED
Craniotomy
Yonsei University
 2012-06
NCT01737905 COMPLETED
Asthma
Amphastar Pharmaceuticals, Inc.
 2012-10 PHASE3
NCT01989312 COMPLETED
Orthopaedic Disorders; Nerve Block; Anaesthesia
Ankara University
 2012-02 PHASE4
NCT01794533 COMPLETED
Painful Irreversible Pulpitis
Islamic Azad University, Sanandaj
 2012-10 PHASE2
NCT01611324 COMPLETED
Varicose Veins; Pain; Surgery; Anesthesia
Campus Bio-Medico University
 2012-05 PHASE4
NCT02457325 COMPLETED
Impacted Third Molar Tooth; Adverse Reaction to Other Local Anesthetics
University of Sao Paulo
 2011-06 PHASE4
NCT01064986 COMPLETED
Infections
Rutgers, The State University of New Jersey
 2010-02 PHASE1
NCT01497509 WITHDRAWN
Neonatal Neurobehavior; Breastfeeding Outcomes
University Hospitals Cleveland Medical Center
 2012-05
NCT01405768 COMPLETED
Uterine Cervical Dysplasia
Washington University School of Medicine
 2011-07 PHASE2
NCT01871857 COMPLETED
Acute Bronchiolitis
Le Bonheur Children's Hospital
 2010-11 PHASE4
NCT01460511 COMPLETED
Asthma
Amphastar Pharmaceuticals, Inc.
 2011-10 PHASE3
NCT00753402 COMPLETED
Immune System
Rutgers, The State University of New Jersey
 2012-02 PHASE1
NCT00548886 TERMINATED
Congenital Disorders
Emory University
 2008-02
NCT01005459 TERMINATED
Labor Pain
Wake Forest University
 2009-08 PHASE4
NCT01080625 COMPLETED
Hypotension After Reperfusion in Liver Transplantation
Seoul National University Hospital
 2010-04
NCT01432522 COMPLETED
Anaphylaxis
Siriraj Hospital
 2010-07
NCT01042093 COMPLETED
Osteoarthritis,Knee
Towson Orthopaedic Associates
 2010-01
NCT01091766 COMPLETED
Anaesthesia; Toxicity
University Children's Hospital, Zurich
 2010-03 PHASE4
NCT01395043 COMPLETED
Postoperative Pain
Aalborg University Hospital
 2010-09
NCT01572116 COMPLETED
Irreversible Pulpitis
Islamic Azad University, Sanandaj
 2010-01 PHASE2
NCT01276821 COMPLETED
Bronchiolitis
Dr. Aayush Khanal, MD
 2011-01 PHASE4
NCT01264575 COMPLETED
Spinal Anesthesia; Total Knee Replacement Arthroplasty
Seoul Medical Center
 2009-12
NCT01255709 COMPLETED
Asthma
Amphastar Pharmaceuticals, Inc.
 2010-12 PHASE2
NCT01912755 COMPLETED
Irreversible Pulpitis; Pain
University of Campinas, Brazil
 2010-02 PHASE4
NCT00564655 TERMINATED
Anesthesia; Enteral Nutrition
The Hospital for Sick Children
 2007-10 PHASE3
NCT00628550 COMPLETED
Cardiopulmonary Arrest; Cardiac Arrest
University of Texas Southwestern Medical Center
 2008-04 PHASE1
NCT01188577 COMPLETED
Asthma; Bronchospasm; Wheezing; Shortness of Breath
Amphastar Pharmaceuticals, Inc.
 2010-08 PHASE1; PHASE2
NCT00980616 COMPLETED
Arthroplasty, Replacement, Hip
University Hospital, Clermont-Ferrand
 2009-09 PHASE2
NCT01131741 UNKNOWN
Injections, Intravenous
Seoul National University Hospital
 2010-05
NCT01060930 COMPLETED
Vascular Function in Healthy Volunteers
University of Edinburgh
 2010-03
NCT01300325 COMPLETED
Bronchiolitis
Federico II University
 2008-11 PHASE4
NCT01025648 TERMINATED
Asthma
Amphastar Pharmaceuticals, Inc.
 2009-12 PHASE1; PHASE2
NCT01116609 COMPLETED
Healthy
University of Aarhus
 2004-10
NCT01708967 COMPLETED
Pretreatment Method of Transnasal Endoscopy
Chuncheon Sacred Heart Hospital
 2009-03
NCT00889642 COMPLETED
Local Anesthesia
Dharma Therapeutics Inc.
 2009-05 PHASE2
NCT01016249 COMPLETED
Bronchiolitis
Hamad Medical Corporation
 2007-04 PHASE4
NCT00165009 TERMINATED
Peptic Ulcer Hemorrhage
Chinese University of Hong Kong
 2005-06 PHASE3
NCT01719978 COMPLETED
Cardiac Arrhythmias
Mauricio Jose Tornelli
 2007-10 PHASE4
NCT00225043 COMPLETED
Healthy
New York Presbyterian Brooklyn Methodist Hospital
 2005-06
NCT00411879 COMPLETED
Heart Arrest
University of Athens
 2006-06 PHASE2
NCT00622817 COMPLETED
Bronchiolitis
Schneider Children's Medical Center, Israel
 2004-10
NCT00148278 COMPLETED
Septic Shock; Severe Sepsis; Infections
University of Versailles
 1999-10 PHASE2; PHASE3
NCT00728832 COMPLETED
Postoperative Pain
EKR Therapeutics, Inc
 2002-05 PHASE1
NCT00134212 COMPLETED
Septic Shock
Rennes University Hospital
 2002-03 PHASE2
NCT00605774 WITHDRAWN
Type 1 Diabetes
Vanderbilt University
NCT00298571 COMPLETED
Pain, Postoperative
University of South Florida
 2006-02 PHASE2; PHASE3
NCT00608816 WITHDRAWN
Type 1 Diabetes
Vanderbilt University
NCT00114478 UNKNOWN
Bronchiolitis
Kern Medical Center
 2003-11

(data from https://clinicaltrials.gov, updated on 2026-08-25)

Check the Epinephrine HCl product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Epinephrine hydrochloride binds to alpha- and beta-adrenergic receptors, activating G-protein-coupled signaling cascades that elevate intracellular cyclic AMP levels and modulate smooth muscle tone, cardiac contractility, and vascular resistance. This potent adrenergic stimulation induces systemic vasoconstriction and bronchodilation, providing crucial hemodynamic stabilization and physiological support in clinical conditions such as septic shock and severe anaphylactic reactions.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

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Note: Technical data last updated: Sep 1, 2026.