CAS No. 1257-08-5

Batch: Purity:99.87
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(-)-Epicatechin gallate Chemical Structure
Chemical Structure
Check the (-)-Epicatechin gallate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 1257-08-5
Molecular Formula

C22H18O10
Molecular Weight (MW) 442.37
SMILES C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O

Ordering Information

Biological Activity

(-)-Epicatechin gallate (ECG) is a natural polyphenolic flavonoid that acts as an inhibitor of cyclooxygenase-1 (COX-1). By inhibiting COX-1 activity and modulating arachidonic acid metabolism, ECG regulates key cellular cascade pathways including NF-kB. This downstream modulation leads to suppressed pro-inflammatory mediator release, inhibited cell proliferation, and induced apoptosis in affected cellular models.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 88 mg/mL (198.92 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.