🎯 check Entrectinib (Rxdx-101) product page
Entrectinib is a potent, broad-spectrum ATP-competitive TRK, ROS1, and ALK inhibitor. It affects MAPK, PI3K/AKT, and STAT3 signaling pathways by binding to the kinase ATP-binding pocket to prevent autophosphorylation, effectively inhibiting tumor cell proliferation and inducing apoptosis.