Entrectinib (Rxdx-101) IC50 for Cell-based and Cell-free Assays

Entrectinib is a potent, broad-spectrum ATP-competitive TRK, ROS1, and ALK inhibitor. It affects MAPK, PI3K/AKT, and STAT3 signaling pathways by binding to the kinase ATP-binding pocket to prevent autophosphorylation, effectively inhibiting tumor cell proliferation and inducing apoptosis.

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