CAS No. 1316755-16-4
Batch:
Purity:99.66
Chemical Structure
Check the
Olodanrigan (EMA401)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 1316755-16-4 | |
|---|---|---|
| Molecular Formula |
C32H29NO5 |
|
| Molecular Weight (MW) | 507.58 | |
| SMILES | COC1=C(C2=C(CN(C(C2)C(=O)O)C(=O)C(C3=CC=CC=C3)C4=CC=CC=C4)C=C1)OCC5=CC=CC=C5 |
Biological Activity
Olodanrigan (EMA401) is an orally active, highly selective, peripherally restricted antagonist of the angiotensin II type 2 receptor (AT2R). By blocking AT2R signaling, olodanrigan inhibits angiotensin II-induced activation of p38 and p42/p44 MAPK pathways. This inhibition suppresses hyperexcitability and neurite sprouting in dorsal root ganglion neurons, ultimately mediating its targeted analgesic activity in preclinical pain models. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(197.01 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.