Elesclomol (STA-4783): Selectivity & Specificity

Elesclomol (STA-4783) is a potent inhibitor of MCF-7 (110 nM), SK-MEL-5 (24 nM), HL-60 (9 nM), UCP2, ROS, ISC protein, Mitochondrial acyltransferase protein, OXPHOS, FDX1, DLAT, Fe-S cluster, NPL4, Mitochondrial NADH-ubiquinone oxidoreductase, ATP7A, SLC7A11, CASP3, CASP9, BCL2L1, BCL2, VIM, CDH1, MMP2, MMP9, TOS, MDA, Mitochondrial membrane potential, PARP, Glutamine, α-ketoglutarate, Succinate, Citric acid, Cis-aconitate, Sedoheptulose 7-phosphate, NFKB, CDKN1B, CDKN1A, MAPK14, JNK, AKT, HSP70, COX, SOD1, LOX, DBH, CP, PAM, TYR, OGDH, PDH, LIAS, TCA cycle proteins, GNAQ, GNA11, LATS1, YAP1, TXN, Fe2+, Mitochondrial iron, FET3, FTR1, CGAS, STING1, GSH, ETC, ACO2, POLD1, Mitochondrial DNA, PD-L1, Cuproptosis, Mitochondrial apoptosis, Ascorbate, Copper ions. Elesclomol (STA-4783) exhibits the greatest inhibitory potency toward HL-60 (IC50 = 9 nM).