CAS No. 488832-69-5

Batch: Purity:99.60
Check CoA
Elesclomol (STA-4783) Chemical Structure
Chemical Structure
Check the Elesclomol (STA-4783) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1-N',3-N'-bis(benzenecarbonothioyl)-1-N',3-N'-dimethylpropanedihydrazide
CAS Number 488832-69-5
Molecular Formula

C19H20N4O2S2
Molecular Weight (MW) 400.5
SMILES CN(C(=S)C1=CC=CC=C1)NC(=O)CC(=O)NN(C)C(=S)C2=CC=CC=C2
InChIKey BKJIXTWSNXCKJH-UHFFFAOYSA-N

Ordering Information

Biological Activity

Elesclomol (STA-4783) is a potent copper ionophore and oxidative stress inducer that directly binds ferredoxin 1 (FDX1) to inhibit FDX1-mediated iron-sulfur cluster biosynthesis. By increasing intracellular copper levels, it rapidly stimulates reactive oxygen species generation and upregulates Hsp70 and metallothionein expression. This mechanism impairs mitochondrial function, triggering copper-dependent cell death (cuproptosis) and apoptosis across a broad range of cancer cell types. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 80 mg/mL (199.75 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Aliquotting Service

Free Aliquotting Service

Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.

Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.

Jump to

Note: Technical data last updated: Sep 1, 2026.