CAS No. 923978-27-2
| IUPAC Name | 2-[2,6-dimethyl-4-[(E)-3-(4-methylsulfanylphenyl)-3-oxoprop-1-enyl]phenoxy]-2-methylpropanoic acid | |
|---|---|---|
| CAS Number | 923978-27-2 | |
| Molecular Formula |
C22H24O4S |
|
| Molecular Weight (MW) | 384.49 | |
| SMILES | CC1=CC(=CC(=C1OC(C)(C)C(=O)O)C)C=CC(=O)C2=CC=C(C=C2)SC | |
| InChIKey | AFLFKFHDSCQHOL-IZZDOVSWSA-N |
Elafibranor (GFT505) is a dual agonist targeting peroxisome proliferator-activated receptor-α (PPAR-α) and peroxisome proliferator-activated receptor-δ (PPAR-δ). Activation of these nuclear receptors modulates transcription within downstream metabolic networks, leading to enhanced insulin sensitivity and improved glucose homeostasis. Furthermore, Elafibranor regulates lipid metabolism and suppresses inflammatory pathways, thereby reducing systemic inflammation and supporting overall metabolic function. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
76 mg/mL
(197.66 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 60 mg/mL |
| Water | Insoluble |
| DMSO |
76 mg/mL
(197.66 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 76 mg/mL |
| Water | Insoluble |
| DMSO |
77 mg/mL
(200.26 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 50 mg/mL |
| Water | Insoluble |
| DMSO |
77 mg/mL
(200.26 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 16 mg/mL |
| Water | Insoluble |
| DMSO |
77 mg/mL
(200.26 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 13 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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