CAS No. 2758659-09-3
Batch:
Purity:97.87
Chemical Structure
Check the
AZD5004 (ECC5004)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 3-[1-[2-[(4S)-2-(3-cyclopropyl-4-fluorophenyl)-3-[3-(4-fluoro-1-methylindazol-5-yl)-2-oxoimidazol-1-yl]-4-methyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carbonyl]-7-(2,2-dimethyloxan-4-yl)indolizin-3-yl]cyclopropyl]-4H-1,2,4-oxadiazol-5-one | |
|---|---|---|
| CAS Number | 2758659-09-3 | |
| Molecular Formula |
C48H46F2N10O5 |
|
| Molecular Weight (MW) | 880.94 | |
| InChIKey | JMKBTILBGROESC-QUWDGAPNSA-N |
Biological Activity
AZD5004 (ECC5004) is an orally active, small-molecule agonist of the glucagon-like peptide-1 receptor (GLP-1R). Upon binding to human GLP-1R, AZD5004 selectively activates cyclic adenosine monophosphate (cAMP) signaling without inducing β-arrestin-2 recruitment or receptor internalization. This G-protein–biased pathway activation potentiates glucose-stimulated insulin secretion in pancreatic β-cells, supporting its key role in regulating glucose homeostasis and metabolic function. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(113.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
Jump to
Note: Technical data last updated: Sep 1, 2026.