2D Structure
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2D chemical structural formula diagram.
3D Structure
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This 3D model represents a theoretically simulated conformation and is for reference only.
Check the
Lotamilast (RVT-501)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | methyl 4-[[3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl]carbamoyl]benzoate | |
|---|---|---|
| CAS Number | 947620-48-6 | |
| Molecular Formula |
C26H24N4O5 |
|
| Molecular Weight (MW) | 472.49 | |
| SMILES | CNC1=NC2=CC(=C(C=C2C(=N1)C3=CC(=CC=C3)NC(=O)C4=CC=C(C=C4)C(=O)OC)OC)OC | |
| InChIKey | BBTFKAOFCSOZMB-UHFFFAOYSA-N |
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
94 mg/mL
(198.94 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
- Lotamilast (RVT-501) Clinical Trials
- Lotamilast (RVT-501) Solubility in DMSO
- Lotamilast (RVT-501) Stock Solution
- Lotamilast (RVT-501) Storage
- Lotamilast (RVT-501) Stability
- Lotamilast (RVT-501) Molecular Weight
- Lotamilast (RVT-501) SMILES
- Lotamilast (RVT-501) CAS Number
- Lotamilast (RVT-501) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.