CAS No. 947620-48-6

Batch: Purity:99.66
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Lotamilast (RVT-501) Chemical Structure
Chemical Structure
Check the Lotamilast (RVT-501) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name methyl 4-[[3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl]carbamoyl]benzoate
CAS Number 947620-48-6
Molecular Formula

C26H24N4O5
Molecular Weight (MW) 472.49
SMILES CNC1=NC2=CC(=C(C=C2C(=N1)C3=CC(=CC=C3)NC(=O)C4=CC=C(C=C4)C(=O)OC)OC)OC
InChIKey BBTFKAOFCSOZMB-UHFFFAOYSA-N

Ordering Information

Biological Activity

Lotamilast (RVT-501, E6005) is a potent and selective phosphodiesterase 4 (PDE4) inhibitor. Targeted inhibition of PDE4 prevents the hydrolysis of intracellular cyclic adenosine monophosphate (cAMP), leading to cAMP accumulation in immune cells. Downstream, elevated cAMP signaling suppresses the activation of pro-inflammatory transcription factors and reduces the expression of inflammatory cytokines, thereby attenuating immune-mediated cutaneous inflammation.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 94 mg/mL (198.94 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.