CAS No. 3483-12-3
| IUPAC Name | (2R,3R)-1,4-bis(sulfanyl)butane-2,3-diol | |
|---|---|---|
| CAS Number | 3483-12-3 | |
| Molecular Formula |
C4H10O2S2 |
|
| Molecular Weight (MW) | 154.25 | |
| SMILES | C(C(C(CS)O)O)S | |
| InChIKey | VHJLVAABSRFDPM-IMJSIDKUSA-N |
DTT (Dithiothreitol) is a small-molecule redox reagent and reducing agent that specifically cleaves disulfide bonds in biological molecules. By quantitatively reducing disulfide bridges into free sulfhydryl groups, DTT maintains target proteins in a reduced state and prevents oxidative cross-linking or disulfide-mediated aggregation. This conformational modulation regulates disulfide-dependent enzymatic activities and preserves active-site cysteine function across diverse biological signaling pathways.
| Solvent | Solubility & Note |
|---|---|
| DMSO |
31 mg/mL
(200.97 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 31 mg/mL |
| Ethanol | 31 mg/mL |
| DMSO |
31 mg/mL
(200.97 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 31 mg/mL |
| Ethanol | 31 mg/mL |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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