CAS No. 562-10-7

Batch: Purity:99.72
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Doxylamine Succinate Chemical Structure
Chemical Structure
Check the Doxylamine Succinate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name butanedioic acid;N,N-dimethyl-2-(1-phenyl-1-pyridin-2-ylethoxy)ethanamine
CAS Number 562-10-7
Molecular Formula

C17H22N2O.C4H6O4
Molecular Weight (MW) 388.46
SMILES CC(C1=CC=CC=C1)(C2=CC=CC=N2)OCCN(C)C.C(CC(=O)O)C(=O)O
InChIKey KBAUFVUYFNWQFM-UHFFFAOYSA-N

Biological Activity

Doxylamine succinate is a first-generation histamine H1 receptor antagonist that competitively inhibits histamine binding to H1 receptors. By blocking H1 receptor-mediated signaling, doxylamine suppresses downstream histamine-induced responses in central and peripheral tissues. This inhibition leads to significant sedative effects and anticholinergic activity, modulating neurohistaminergic pathways involved in wakefulness and smooth muscle contraction. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 78 mg/mL (200.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 78 mg/mL
Ethanol 78 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Simons FE, et al. J Allergy Clin Immunol. 2011;128(6):1139-1150.e4.

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Note: Technical data last updated: Sep 1, 2026.