Clinical Trials

Numerous clinical trials, ranging from early phase to Phase 4, evaluate doxycycline hydrochloride across a wide spectrum of conditions, including bacterial and sexually transmitted infections, chronic inflammatory diseases, joint infections, malignancies, and neurodegenerative disorders like Alzheimer's disease. Driven by academic institutions, international research networks, and regional health organizations, these studies encompass active recruitment, ongoing, and completed protocols.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT07485010 NOT_YET_RECRUITING
Mycobacterium Abscessus Pulmonary Disease; Mycobacterium Abscessus Infection; Non-Tuberculous Mycobacterial (NTM) Infections; Non-Tuberculous Mycobacteria Pulmonary Disease
The University of Queensland
 2027-04 PHASE2
NCT07704957 NOT_YET_RECRUITING
Chlamydia Females; Gonorrhea Female; Syphilis Female; Adherence; Prophylaxis; Prevention
Tulane University
 2027-01-01 PHASE4
NCT07488949 RECRUITING
Chronic Endometritis
Fang Wang
 2024-04-09
NCT07164131 RECRUITING
Community-acquired Pneumonia
Mayo Clinic
 2025-09-15 PHASE4
NCT05473520 RECRUITING
Tuberculosis; Acute Coronary Syndrome; Pulmonary Hypertension (Diagnosis)
National University Hospital, Singapore
 2023-05-24 PHASE3
NCT07658976 NOT_YET_RECRUITING
HIV Infection; Sexually Transmitted Infection
HIV Prevention Trials Network
 2026-09-01 PHASE3
NCT07629167 NOT_YET_RECRUITING
Acneiform Drug Eruption; Acneiform Eruptions
University of California, San Francisco
 2026-08-30 PHASE2
NCT04310930 RECRUITING
Pulmonary Disease Due to Mycobacteria (Diagnosis)
The University of Queensland
 2020-03-02 PHASE2; PHASE3
NCT07215325 RECRUITING
Sexually Transmitted Infections (STI)
Emory University
 2025-10-13 PHASE4
NCT07510048 NOT_YET_RECRUITING
HIV; STIs; STIs Prevention; HIV Prevention
Westat
 2026-07-20 PHASE2
NCT07306234 NOT_YET_RECRUITING
Mycoplasma Pneumoniae; Mycoplasma Pneumoniae Pneumonia
Young June Choe
 2026-03-01 PHASE4
NCT03462329 RECRUITING
Erythema Migrans
University Medical Centre Ljubljana
 2018-06-01
NCT06468462 RECRUITING
Gonorrhea Male; Chlamydia (Male); Syphilis Male
University of Washington
 2025-10-29 PHASE4
NCT06414408 RECRUITING
Sexually Transmitted Diseases, Bacterial
University of California, San Francisco
 2024-10-18 EARLY_PHASE1
NCT06452394 RECRUITING
Breast Cancer
Swiss Cancer Institute
 2025-07-16 PHASE2
NCT06738407 RECRUITING
Gonorrhea; Chlamydia; Syphilis; Sexually Transmitted Infections (STIs)
Westat
 2026-02-27 PHASE4
NCT05268120 RECRUITING
MRSA
Leiden University Medical Center
 2022-07-25
NCT03956446 RECRUITING
Tick Borne Encephalitis
University Medical Centre Ljubljana
 2014-09-01
NCT05100654 ACTIVE_NOT_RECRUITING
Erectile Dysfunction; Penile Prosthesis Infection
University of Chicago
 2022-04-22 EARLY_PHASE1
NCT03337932 RECRUITING
Erythema Chronicum Migrans
University Medical Centre Ljubljana
 2018-05-01
NCT06069141 RECRUITING
Early Syphilis, Latent, Serological Relapse After Treatment
National Taiwan University Hospital
 2024-01-01
NCT06188442 ACTIVE_NOT_RECRUITING
Sexually Transmitted Diseases, Bacterial; Syphilis; Gonorrhea; Chlamydia
Chinese University of Hong Kong
 2025-03-29 PHASE4
NCT07779629 NOT_YET_RECRUITING
Brucellosis; Osteoarthritis
The First Affiliated Hospital of Shihezi University
 2026-09-01
NCT07230028 NOT_YET_RECRUITING
Lyme Borreliosis, Nervous System
Radboud University Medical Center
 2027-03-01 PHASE4
NCT07767422 NOT_YET_RECRUITING
Lymphogranuloma Venereum; no Anorectal Symptoms; Doxycycline
University Hospital, Bordeaux
 2026-09 PHASE2
NCT06446245 RECRUITING
Tuberculosis, Meningeal; Tuberculosis; Meningitis (Etiology); Tuberculosis, Central Nervous System; Tuberculosis; Meningoencephalitis (Etiology)
National University Hospital, Singapore
 2025-08-21 PHASE2
NCT07500415 RECRUITING
Sexually Transmitted Diseases; Syphilis; Gonorrhea; Chlamydia Infections; HIV Infections
Oswaldo Cruz Foundation
 2025-10-28
NCT07688096 NOT_YET_RECRUITING
Ehlers-Danlos Syndrome Hypermobility Type (hEDS); Ehlers-Danlos Syndrome (EDS); Joint Hypermobility; Joint Instability; Hypermobility Spectrum Disorder; Chronic Pain Syndrome; Musculoskeletal Pain; Sprain; Subluxation; Dislocation; Craniocervical Disfunction
Manhattan Pain Medicine, PLLC
 2026-07-15 PHASE1; PHASE2
NCT04108897 ACTIVE_NOT_RECRUITING
Rosacea
Johns Hopkins University
 2019-09-17 EARLY_PHASE1
NCT07343635 RECRUITING
Erythematotelangiectatic Rosacea
The Fourth Affiliated Hospital of Zhejiang University School of Medicine
 2026-02-01
NCT07755618 NOT_YET_RECRUITING
Sexually Transmitted Infection
HIV Prevention Trials Network
 2026-08-01 PHASE1
NCT07024654 WITHDRAWN
Chronic Knee Pain; Osteoarthritis
Campbell Clinic
 2026-06 PHASE2
NCT07634341 NOT_YET_RECRUITING
Chronic Periodontitis
Fayoum University
 2026-06 PHASE4
NCT06120140 ACTIVE_NOT_RECRUITING
Carcinoma, Non-Small-Cell Lung
Janssen Research & Development, LLC
 2024-02-16 PHASE2
NCT07498010 RECRUITING
Seroma
University of Miami
 2026-05-31 PHASE2
NCT07544251 RECRUITING
Acne Vulgaris
Integrative Skin Science and Research
 2026-04-20 PHASE4
NCT05382208 ACTIVE_NOT_RECRUITING
Emphysema; HIV
Weill Medical College of Cornell University
 2022-08-22 PHASE2
NCT01631617 RECRUITING
Eczema; Dermatitis; Skin Diseases, Genetic; Dermatitis, Atopic; Skin Diseases
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
 2012-09-18 PHASE2
NCT04297592 ENROLLING_BY_INVITATION
Infections Joint Prosthetic; Overweight or Obesity; MSSA Colonization; MRSA; Chronic Kidney Diseases; Diabetes; Autoimmune Diseases; Inflammatory Disease; Tobacco Use
Mayo Clinic
 2020-06-11 PHASE4
NCT02713607 ACTIVE_NOT_RECRUITING
Acne Vulgaris
University of California, Davis
 2016-03 PHASE1; PHASE2
NCT04504123 RECRUITING
Exudative Macular Degeneration; Wet Age-related Macular Degeneration
University of Iowa
 2020-11-04 PHASE2
NCT04762134 RECRUITING
Bacterial Sexually Transmitted Diseases
Jonathan Troy Grennan
 2023-06-02
NCT06477185 RECRUITING
Tuberculosis, Pulmonary
Makerere University
 2024-12-04 PHASE2
NCT07180563 RECRUITING
Chronic Endometritis
The Fourth Affiliated Hospital of Zhejiang University School of Medicine
 2025-03-15 PHASE1; PHASE2
NCT06045481 NOT_YET_RECRUITING
Relapsing Fever, Tick-Borne
Medical Corps, Israel Defense Force
 2024-08-01
NCT03083197 ACTIVE_NOT_RECRUITING
Scrub Typhus
University of Oxford
 2017-10-15 PHASE4
NCT07397403 RECRUITING
Syphilis Infection; Gonorrhea; Chlamydia
Bangrak STIs Center
 2025-10-06 PHASE4
NCT03435952 ACTIVE_NOT_RECRUITING
Malignant Neoplasm of Breast; Malignant Neoplasms of Digestive Organs; Malignant Neoplasms of Eye Brain and Other Parts of Central Nervous System; Malignant Neoplasms of Female Genital Organs; Malignant Neoplasms of Ill-defined Secondary and Unspecified Sites; Malignant Neoplasms of Independent (Primary) Multiple Sites; Malignant Neoplasms of Lip Oral Cavity and Pharynx; Malignant Neoplasms of Male Genital Organs; Malignant Neoplasms of Mesothelial and Soft Tissue; Malignant Neoplasms of Respiratory and Intrathoracic Organs; Malignant Neoplasms of Thyroid and Other Endocrine Glands; Malignant Neoplasms of Urinary Tract
M.D. Anderson Cancer Center
 2018-07-10 PHASE1
NCT05521048 ACTIVE_NOT_RECRUITING
Neurofibromatosis Type 2
Massachusetts Eye and Ear Infirmary
 2022-09-19 PHASE1; PHASE2
NCT06616168 ACTIVE_NOT_RECRUITING
Bacterial Vaginosis
Danylo Halytsky Lviv National Medical University
 2023-09-01 PHASE1
NCT07320001 NOT_YET_RECRUITING
Lymphatic Abnormality
Basharat Hussain
 2026-01-26 PHASE2
NCT06809829 RECRUITING
Immediate Implant Placement
Kafrelsheikh University
 2025-02
NCT05061732 UNKNOWN
Helicobacter Pylori Infection
Shanghai Zhongshan Hospital
 2021-09-30 PHASE4
NCT06683638 RECRUITING
Syphilis
University of Washington
 2025-03-03 PHASE2
NCT06329882 RECRUITING
Diabetes Mellitus, Type 2
Mostafa Bahaa
 2024-03-30 PHASE1; PHASE2
NCT04582383 ACTIVE_NOT_RECRUITING
Acne
University of Pennsylvania
 2022-03-30 PHASE4
NCT05840159 COMPLETED
Chlamydial Infection
National Institute of Allergy and Infectious Diseases (NIAID)
 2024-01-19 PHASE4
NCT01917721 ACTIVE_NOT_RECRUITING
Kawasaki Disease; Coronary Aneurysm
Hawaii Pacific Health
 2013-10 PHASE2
NCT06412588 COMPLETED
Helicobacter Pylori Infection
Nanjing First Hospital, Nanjing Medical University
 2024-06-15
NCT05398055 UNKNOWN
Rocky Mountain Spotted Fever
Hospital General de Mexicali
 2022-05-12 PHASE3
NCT05112211 RECRUITING
Thyroid Associated Ophthalmopathy
Sun Yat-sen University
 2022-01-01
NCT05874570 RECRUITING
Helicobacter Pylori Infection
Shanghai Jiao Tong University School of Medicine
 2023-06-20 PHASE4
NCT04686799 COMPLETED
Lateral Epicondylitis; Lateral Epicondylitis, Left Elbow; Lateral Epicondylitis, Right Elbow; Lateral Epicondylitis, Unspecified Elbow; Lateral Epicondylitis (Tennis Elbow) Bilateral; Medial Epicondylitis; Medial Epicondylitis, Right Elbow; Medial Epicondylitis, Left Elbow
Hospital for Special Surgery, New York
 2020-12-03 PHASE1
NCT05972772 RECRUITING
Infectious Disease; Therapeutics
Lao-Oxford-Mahosot Hospital Wellcome Trust Research Unit
 2024-11-01 PHASE2; PHASE3
NCT07357337 COMPLETED
Acne Vulgaris on the Face; Acne Vulgaris
Ghurki Trust and Teaching Hospital
 2025-02-15 PHASE4
NCT06994455 UNKNOWN
Periodontitis
Mansoura University
 2024-06-02
NCT06915688 NOT_YET_RECRUITING
COPD
Amina Aslam
 2025-04-15
NCT03508232 COMPLETED
ST Segment Elevation Myocardial Infarction; Heart Failure
University of Alberta
 2020-01-06 PHASE2
NCT05980871 TERMINATED
Early Syphilis
National Taiwan University Hospital
 2023-03-10 PHASE4
NCT04838717 COMPLETED
Syphilis
Assistance Publique - Hôpitaux de Paris
 2021-12-06 PHASE3
NCT05296837 COMPLETED
Ocular Rosacea; Antimicrobial Resistance
University of California, San Francisco
 2023-06-22 PHASE4
NCT06582966 COMPLETED
STI
University of Washington
 2024-08-13 PHASE4
NCT06545656 COMPLETED
Sexually Transmitted Infection
Emory University
 2024-09-13 PHASE4
NCT06007534 UNKNOWN
Post-exposure Prophylaxis; Sexually Transmitted Diseases; Doxycycline
Assistance Publique - Hôpitaux de Paris
 2023-10-25
NCT05977868 TERMINATED
Endovascular Infection; Bone and Joint Infection; Skin and Soft Tissue Infection; Pulmonary Infection; Gastrointestinal Infection; Genitourinary Infection
West Virginia University
 2023-08-04 PHASE4
NCT06422221 UNKNOWN
Bacteremia; Endocarditis
University of Santiago de Compostela
 2024-07-15 PHASE4
NCT07513103 COMPLETED
Scrub Typhus
Jin Soo Lee
 2022-11-19
NCT05853120 COMPLETED
Sexually Transmitted Diseases
Emory University
 2023-05-31 PHASE4
NCT07385300 COMPLETED
Periodontitis; Diabete Mellitus
Alexandria University
 2023-08-20
NCT05878353 COMPLETED
Periodontal Diseases
University of Turin, Italy
 2023-05-30
NCT05897034 NOT_YET_RECRUITING
Sexually Transmitted Diseases
Tanta University
 2023-06-20 PHASE2; PHASE3
NCT07064278 COMPLETED
Refractory Mycoplasma Pneumoniae Pneumonia
Children's Hospital of Hebei Province
 2022-12-01
NCT02864550 COMPLETED
Syphilis; Sexually Transmitted Infections
British Columbia Centre for Disease Control
 2019-08-15 PHASE4
NCT06252194 UNKNOWN
Acne Vulgaris
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
 2023-03-05 PHASE2
NCT06172686 UNKNOWN
Controlled Human Malaria Infection; Induced Blood Stage Malaria Infection; Malaria Transmission; Malaria Challenge
Ifakara Health Institute
 2024-01-09 PHASE1
NCT03637400 COMPLETED
Methicillin-resistant Staphylococcus Aureus; Skin Infection
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
 2018-11-26 PHASE2
NCT06570863 COMPLETED
Periodontitis; Adult
Dr fizza khalid
 2022-07-01
NCT04626193 UNKNOWN
Helicobacter Pylori Infection
Damascus Hospital
 2020-10-31 PHASE4
NCT05708625 UNKNOWN
Leishmaniasis, Cutaneous
Zagazig University
 2022-01-01 PHASE3
NCT05111002 TERMINATED
Mycoplasma Genitalium Infection
University of Washington
 2022-04-22 PHASE1; PHASE2
NCT05157412 COMPLETED
Nasal Polyps; Chronic Rhinosinusitis With Nasal Polyps
Assiut University
 2021-07-01 PHASE3
NCT05875506 COMPLETED
Osteitis; Dry Socket
Minia University
 2023-05-01
NCT05343455 COMPLETED
Papulopustular Rosacea
Journey Medical Corporation
 2022-03-29 PHASE3
NCT05296629 COMPLETED
Papulopustular Rosacea
Journey Medical Corporation
 2022-03-14 PHASE3
NCT05431673 UNKNOWN
Rhinoscleroma
Assiut University
 2022-08-21 PHASE1
NCT03980223 COMPLETED
Gonorrhea; Chlamydia; Syphilis
University of California, San Francisco
 2019-11-26 PHASE4
NCT06199440 COMPLETED
Periodontal Diseases; Type 2 Diabetes
King Abdulaziz University
 2022-06-01 PHASE1; PHASE2
NCT04597424 COMPLETED
Unsafe Sex; Risk-Taking
ANRS, Emerging Infectious Diseases
 2021-01-19 PHASE3
NCT03334682 COMPLETED
Acne Vulgaris
Nantes University Hospital
 2018-01-31 PHASE3
NCT04723940 UNKNOWN
Joint Infection
Rothman Institute Orthopaedics
 2021-01-25 PHASE3
NCT03481972 COMPLETED
TTR Cardiac Amyloidosis
Fondazione IRCCS Policlinico San Matteo di Pavia
 2018-04-11 PHASE3
NCT05492019 UNKNOWN
Parkinson Disease
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
 2022-07-01 PHASE2
NCT03911440 UNKNOWN
Atypical Pneumonia
National Taiwan University Hospital
 2018-11-10
NCT05018923 UNKNOWN
Helicobacter Pylori Infection
Shanghai Zhongshan Hospital
 2021-08-24 PHASE4
NCT05410223 UNKNOWN
Helicobacter Pylori Infection
The Third Xiangya Hospital of Central South University
 2021-04-06
NCT04864717 UNKNOWN
Acneiform Eruptions; Cancer, Treatment-Related
Lady Davis Institute
 2021-09-01 PHASE4
NCT04234945 UNKNOWN
Infertility, Female; Pelvic Inflammatory Disease
Ahmadu Bello University Teaching Hospital
 2020-01-13
NCT04050540 COMPLETED
HIV Infections; HIV/AIDS; Neisseria Gonorrheae Infection; Chlamydia Trachomatis Infection; Syphilis Infection
University of Washington
 2020-02-05 PHASE4
NCT05401422 UNKNOWN
Rosacea
Cairo University
 2022-05-25
NCT03162497 COMPLETED
Dry Eye Syndromes; Meibomian Gland Dysfunction
Medical University of Vienna
 2018-01-08 PHASE4
NCT02203682 UNKNOWN
Graves Ophthalmopathy; Graves Disease; Thyroid-associated Ophthalmopathy; Thyroid Diseases; Endocrine System Diseases; Eye Diseases, Hereditary; Hyperthyroidism; Autoimmune Diseases; Immune System Diseases
Sun Yat-sen University
 2014-07 PHASE2
NCT06090565 COMPLETED
Gonorrhea
Bulovka Hospital
 2021-04-01 PHASE4
NCT05097846 UNKNOWN
Helicobacter Pylori Infection
wang xiaoyan
 2021-06-17
NCT03474458 TERMINATED
Cardiac AL Amyloidosis
Fondazione IRCCS Policlinico San Matteo di Pavia
 2019-02-11 PHASE2; PHASE3
NCT03986996 TERMINATED
Ulcerative Colitis
Wolfson Medical Center
 2019-07-25 PHASE2
NCT04482686 COMPLETED
COVID; Covid-19; Corona Virus Infection; Coronavirus Infection; Coronavirus-19; SARS-CoV2; SARS-CoV Infection
ProgenaBiome
 2020-12-09 PHASE1
NCT03968562 UNKNOWN
Hives
State University of New York - Downstate Medical Center
 2019-05-15 PHASE2
NCT04860505 COMPLETED
Sexually Transmitted Diseases
Emory University
 2021-05-20 PHASE4
NCT05191875 COMPLETED
Helicobacter Pylori Infection
The Third Xiangya Hospital of Central South University
 2021-12-01
NCT05216744 COMPLETED
Neisseria Gonorrhoeae Infection; Chlamydia Trachomatis Infection
Haiphong University of Medicine and Pharmacy
 2021-07-15 PHASE2
NCT03479502 COMPLETED
Adhesive Capsulitis; Adhesive Capsulitis of Unspecified Shoulder; Frozen Shoulder
Vanderbilt University Medical Center
 2018-03-05 PHASE4
NCT03530319 UNKNOWN
Pneumonia, Mycoplasma
National Taiwan University Hospital
 2018-11-10
NCT01411202 UNKNOWN
Malignant Pleural Effusion
Ottawa Hospital Research Institute
 2011-06 PHASE2
NCT04729140 UNKNOWN
Covid19
Max Health, Subsero Health
 2020-12-28 PHASE4
NCT05399290 COMPLETED
Acne Vulgaris; Pediatrics
Michigan State University
 2020-11-19 PHASE4
NCT03173053 TERMINATED
Staphylococcus Aureus; Motility Disorder
Radboud University Medical Center
 2018-02-08
NCT05545462 COMPLETED
Umbilical Granuloma
Shaheed Zulfiqar Ali Bhutto Medical University
 2020-10-01
NCT04636125 UNKNOWN
Periprosthetic Infection; Oral Antibiotics; Revision Total Shoulder Arthroplasty
Rothman Institute Orthopaedics
 2019-09-24 PHASE3
NCT03655197 COMPLETED
Rosacea; Ocular Rosacea; Cutaneous Rosacea
University of California, Davis
 2017-11-02 EARLY_PHASE1
NCT02929121 COMPLETED
Lymphedema; Lymphatic Filariasis; Filariasis
The Task Force for Global Health
 2019-01-15 PHASE3
NCT04167085 COMPLETED
Epistaxis
University of California, Los Angeles
 2017-12-18 PHASE4
NCT04715295 UNKNOWN
COVID-19
Yaounde Central Hospital
 2020-10-05 PHASE4
NCT04451330 COMPLETED
Acne Vulgaris
Galderma R&D
 2020-07-29 PHASE4
NCT04433078 WITHDRAWN
Cytokine Storm; SARS-CoV-2
Temple University
 2020-06-22 PHASE2
NCT04846335 COMPLETED
Familial Fatal Insomnia
Mario Negri Institute for Pharmacological Research
 2011-04-28 PHASE2
NCT03397004 COMPLETED
Hereditary Hemorrhagic Telangiectasia (HHT)
Unity Health Toronto
 2018-09-12 PHASE2
NCT02341209 TERMINATED
Cutaneous T-cell Lymphoma; Mycosis Fungoides; Sezary Syndrome
Rochester General Hospital
 2018-02-06 PHASE2
NCT04584567 COMPLETED
Covid19
Hedi Gharsallah
 2020-11-20 PHASE3
NCT04371952 WITHDRAWN
COVID19
Nantes University Hospital
 2021-02-01 PHASE3
NCT02606032 COMPLETED
Ulcerative Colitis
Hamilton Health Sciences Corporation
 2016-05 PHASE2
NCT03401372 COMPLETED
Amyloidosis; Systemic
Jian Li
 2018-04-21
NCT02583282 COMPLETED
Malignant Pleural Effusion
Post Graduate Institute of Medical Education and Research, Chandigarh
 2015-08-01
NCT03116659 UNKNOWN
Lymphoma, T-Cell, Cutaneous
James J. Peters Veterans Affairs Medical Center
 2018-02-01 EARLY_PHASE1
NCT02927496 COMPLETED
Lymphedema; Lymphatic Filariasis; Filariasis
The Task Force for Global Health
 2018-06-19 PHASE3
NCT02874430 TERMINATED
Breast Carcinoma; Endometrial Clear Cell Adenocarcinoma; Endometrial Serous Adenocarcinoma; Uterine Corpus Cancer; Uterine Corpus Carcinosarcoma
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
 2016-06-08 PHASE2
NCT03322488 UNKNOWN
Perianal Fistula; Crohn Disease
University of Zurich
 2017-06-20
NCT03618108 TERMINATED
Coronary Heart Disease; Chlamydophila Pneumoniae Infections
Cadrock Pty. Ltd.
 2018-04-04 PHASE2
NCT04551755 UNKNOWN
Covid19
Bangladesh Medical Research Council (BMRC)
 2020-09 PHASE2
NCT04407130 COMPLETED
COVID-19 Patients
International Centre for Diarrhoeal Disease Research, Bangladesh
 2020-06-16 PHASE2
NCT04370782 COMPLETED
COVID-19
St. Francis Hospital, New York
 2020-04-28 PHASE4
NCT04591600 COMPLETED
Covid19
Alkarkh Health Directorate-Baghdad
 2020-07-01 PHASE1; PHASE2
NCT04349410 COMPLETED
CoVid 19 Positive
The Camelot Foundation
 2020-04-11 PHASE2; PHASE3
NCT02463942 UNKNOWN
Tick-borne Encephalitis
University Medical Centre Ljubljana
 2014-09
NCT02553083 UNKNOWN
Bacterial Infection Due to Helicobacter Pylori (H. Pylori)
Rabin Medical Center
 2015-10-22 PHASE4
NCT04348786 COMPLETED
Helicobacter Pylori Infection
Damascus Hospital
 2019-02-01 PHASE4
NCT04523831 COMPLETED
Covid19
Dhaka Medical College
 2020-06-01 PHASE3
NCT03532464 COMPLETED
Chlamydia Trachomatis Infection; Vaginal Infection; Anal Infection
University Hospital, Bordeaux
 2018-10-10 PHASE4
NCT04239755 COMPLETED
Traumatic Brain Injury
Damanhour University
 2020-02-01 PHASE4
NCT04528927 WITHDRAWN
COVID 19; Patients Hospitalized
Abderrahmane Mami Hospital
 2020-05-15 PHASE3
NCT04125706 UNKNOWN
Periodontitis
Riyadh Elm University
 2019-11-01
NCT02147262 UNKNOWN
Chronic Atrophic Acrodermatitis
University Medical Centre Ljubljana
 2013-07
NCT02929134 COMPLETED
Lymphedema; Lymphatic Filariasis; Filariasis
The Task Force for Global Health
 2018-02-16 PHASE3
NCT02844634 COMPLETED
HIV; Syphilis
British Columbia Centre for Disease Control
 2018-05-15 PHASE4
NCT03448731 COMPLETED
Skin Toxicity
Fundacion CRIS de Investigación para Vencer el Cáncer
 2018-05-10 PHASE2
NCT02850913 UNKNOWN
Seizures
Makerere University
 2016-09-05 PHASE2
NCT02759120 TERMINATED
Idiopathic Pulmonary Fibrosis
Weill Medical College of Cornell University
 2017-03-22 PHASE3
NCT04067011 COMPLETED
Anthrax
Emergent BioSolutions
 2019-08-12 PHASE2
NCT03608774 COMPLETED
Anal Chlamydia Infection
National Institute of Allergy and Infectious Diseases (NIAID)
 2018-07-13 PHASE4
NCT03194204 COMPLETED
Rheumatoid Arthritis
Assiut University
 2019-10-01
NCT02553473 COMPLETED
Neuroborreliosis, Borrelia Burgdorferi
Sorlandet Hospital HF
 2015-10 PHASE3
NCT03956212 COMPLETED
Erythema Migrans
University Medical Centre Ljubljana
 2017-06-01
NCT01438515 COMPLETED
Methicillin-resistant Staphylococcus Aureus
Horizon Health Network
 2008-08
NCT03153267 COMPLETED
Erythema Chronicum Migrans
University Medical Centre Ljubljana
 2017-06-01
NCT01658995 COMPLETED
ESI-related Bleeding
Petra M. Casey
 2012-09-13 PHASE3
NCT03824340 UNKNOWN
Infertility
Aljazeera Hospital
 2019-01-30
NCT03960411 UNKNOWN
ST Elevation Myocardial Infarction; Anterior Wall Myocardial Infarction; Heart Failure; Remodeling, Ventricular
Felix Chikita Fredy, MD
 2019-05-25 PHASE3
NCT01756833 COMPLETED
Aneurysm
University of Maryland, Baltimore
 2013-05 PHASE2
NCT03342456 COMPLETED
Duodenal Ulcer Due to Helicobacter Pylori
The Third Xiangya Hospital of Central South University
 2017-12-13 PHASE4
NCT01783106 COMPLETED
Crohn's Disease
Royal Liverpool University Hospital
 2014-02-01 PHASE2
NCT02456662 COMPLETED
Drug-induced Nausea and Vomiting
University of Rochester
 2015-10-07
NCT03454945 UNKNOWN
Lymphoma
Cairo University
 2017-03-01 PHASE3
NCT02913118 UNKNOWN
Community Acquired Pneumonia
Qingfeng Pharmaceutical Group
 2016-07 PHASE4
NCT03076281 TERMINATED
Larynx; LIP; Oral Cavity; Pharynx
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
 2017-04-03 PHASE2
NCT02910011 COMPLETED
Dermatitis, Atopic
University of Florida
 2017-05-18 PHASE2
NCT03340961 COMPLETED
Rosacea
Dr. Reddy's Laboratories Limited
 2017-10-01 PHASE2
NCT03457636 COMPLETED
Acne
Derm Research, PLLC
 2018-03-19 PHASE4
NCT02894268 UNKNOWN
Helicobacter Pylori Infection
Sir Run Run Shaw Hospital
 2016-02 PHASE4
NCT02775695 COMPLETED
Resectable Pancreatic Cancer
Medical College of Wisconsin
 2017-04-03 PHASE2
NCT02564471 COMPLETED
Rabies
State University of New York - Upstate Medical University
 2016-11-11 PHASE4
NCT01874860 COMPLETED
Colorectal Cancer; Head and Neck Cancer
University of Louisville
 2013-08 PHASE2
NCT02204254 COMPLETED
Rosacea
Centre Hospitalier Universitaire de Nice
 2014-03
NCT03075891 COMPLETED
Rosacea
Galderma R&D
 2017-07-05 PHASE4
NCT01635530 COMPLETED
Lyme Neuroborreliosis
Turku University Hospital
 2012-08 PHASE4
NCT01594827 COMPLETED
Cystic Fibrosis
Johns Hopkins University
 2012-10 PHASE2
NCT03237533 UNKNOWN
Oral Lichen Planus
University of Faisalabad
 2017-06-01 EARLY_PHASE1
NCT02753426 COMPLETED
Chronic Kidney Disease; Cardiorenal Syndrome
University of California, San Francisco
 2016-04 PHASE1
NCT01847976 COMPLETED
Pain
Ottawa Hospital Research Institute
 2013-08 PHASE2
NCT01163994 UNKNOWN
Multiple Erythema Migrans
University Medical Centre Ljubljana
 2010-06
NCT02207556 COMPLETED
Primary Systemic Amyloidosis
Medical College of Wisconsin
 2014-10-01 PHASE2
NCT02305940 COMPLETED
Chronic Obstructive Pulmonary Disease (COPD)
Imperial College London
 2014-07 PHASE3
NCT02756403 COMPLETED
First Trimester Abortion
Medstar Health Research Institute
 2016-03
NCT01744093 COMPLETED
HIV; Chronic Obstructive Pulmonary Disease (COPD); Emphysema
Weill Medical College of Cornell University
 2014-12-08
NCT02774993 COMPLETED
Tuberculosis
National University Hospital, Singapore
 2015-09 PHASE2
NCT02623959 TERMINATED
Advanced Cancers; Malignant Pleural Effusions
M.D. Anderson Cancer Center
 2016-04-27 PHASE4
NCT02899000 COMPLETED
Acne Vulgaris
Galderma R&D
 2016-07-29 PHASE4
NCT02281643 COMPLETED
Mansonella Perstans Infection; Buruli Ulcer; Tuberculosis; Co-infection
Kwame Nkrumah University of Science and Technology
 2014-10 PHASE2
NCT02562651 UNKNOWN
Vascular Diseases; Cardiovascular Diseases; Acute Myocardial Infarction
Russian Academy of Medical Sciences
 2014-02 PHASE2; PHASE3
NCT03115177 COMPLETED
Osteoarthritis
Rush University Medical Center
 2015-11
NCT03765931 COMPLETED
Fever
Institut de Recherche pour le Developpement
 2016-07 PHASE4
NCT02688738 UNKNOWN
Propionibacterium
Rothman Institute Orthopaedics
 2015-03
NCT01345526 COMPLETED
Metastatic Colorectal Cancer
Universitätsmedizin Mannheim
 2011-04 PHASE2
NCT02726646 COMPLETED
Chronic Periodontitis
University of Campinas, Brazil
 2015-06 PHASE2
NCT03478436 COMPLETED
Rosacea
Medical University of Vienna
 2016-07 PHASE1
NCT01317433 TERMINATED
Colorectal Cancer Metastatic; Skin Toxicity
Institut Cancerologie de l'Ouest
 2010-12-29
NCT01198912 COMPLETED
Chronic Rhinosinusitis; Nasal Polyps
University Hospital, Ghent
 2011-11-22 PHASE2
NCT02569437 TERMINATED
Polyp of Nasal Sinus
Icahn School of Medicine at Mount Sinai
 2014-09 PHASE2
NCT03585140 COMPLETED
Acne Vulgaris; Diet Modification
Centro Dermatológico Dr. Ladislao de la Pascua
 2016-01-01
NCT02388477 WITHDRAWN
Rotator Cuff Injury
Milton S. Hershey Medical Center
NCT01820910 COMPLETED
Marginal Zone Lymphoma of Ocular Adnexal
International Extranodal Lymphoma Study Group (IELSG)
 2013-03-19 PHASE2
NCT02735837 COMPLETED
Diabetes Mellitus With Periodontal Disease
Amirhossein Farahmand
 2015-01 PHASE2; PHASE3
NCT01809444 UNKNOWN
Thyroid Associated Opthalmopathies
Sun Yat-sen University
 2012-11 PHASE2; PHASE3
NCT02845024 COMPLETED
Diabetes Mellitus With Periodontal Disease
Islamic Azad University, Sanandaj
 2014-09
NCT01949233 UNKNOWN
Marfan Syndrome
University of Oxford
 2013-10 PHASE2
NCT02239731 COMPLETED
Rash Due to Epidermal Growth Factor Receptor Inhibitors
Vyne Therapeutics Inc.
 2014-10 PHASE2
NCT04206631 COMPLETED
Acne Vulgaris
Indonesia University
 2015-04-01 PHASE1
NCT01318356 COMPLETED
Q Fever; Fatigue Syndrome, Chronic; Coxiella Infection
Radboud University Medical Center
 2011-04 PHASE4
NCT01160640 COMPLETED
Pelvic Inflammatory Disease
Harold Wiesenfeld
 2010-11 PHASE2
NCT01661985 UNKNOWN
Urethritis; Cervicitis; Genital Mycoplasma Infection; Chlamydia Trachomatis
Ostergotland County Council, Sweden
 2010-02 PHASE4
NCT01590082 TERMINATED
Melanoma
M.D. Anderson Cancer Center
 2012-11 PHASE1; PHASE2
NCT02086591 TERMINATED
Adult Diffuse Large B-Cell Lymphoma; Mantle Cell Lymphoma Recurrent; Lymphoma, Follicular; Marginal Zone B-Cell Lymphoma; Malignant Lymphoma - Lymphoplasmacytic; Waldenstrom Macroglobulinemia; Small Lymphocytic Lymphoma; Chronic Lymphocytic Leukemia (CLL); T-Cell Lymphoma
University of Rochester
 2014-03 PHASE2
NCT01855360 COMPLETED
Amyloidosis; Heart (Manifestation); Senile Cardiac Amyloidosis
Brigham and Women's Hospital
 2013-06 PHASE1; PHASE2
NCT01677286 COMPLETED
Amyloidosis
Boston University
 2012-07 PHASE2
NCT01465802 COMPLETED
Non Small Cell Lung Cancer (NSCLC)
Pfizer
 2011-12-26 PHASE2
NCT01171859 COMPLETED
Transthyretin Amyloidosis
Fondazione IRCCS Policlinico San Matteo di Pavia
 2010-07 PHASE2
NCT01879930 TERMINATED
Chronic Pelvic Pain Syndrome; Bladder Pain Syndrome
Insel Gruppe AG, University Hospital Bern
 2012-11 PHASE4
NCT01668498 COMPLETED
Ras-wildtype Colorectal Cancer
AIO-Studien-gGmbH
 2011-05 PHASE2
NCT02487186 COMPLETED
Periodontal Disease
University of Campinas, Brazil
 2010-03 PHASE4
NCT02036528 TERMINATED
Diabetic Foot Ulcers
Royer Biomedical, Inc.
 2014-01 PHASE1; PHASE2
NCT02016365 COMPLETED
Transthyretin Amyloidosis; Cardiomyopathy
Umeå University
 2012-02 PHASE2
NCT02174757 COMPLETED
Chronic Periodontitis
CD Pharma India Pvt. Ltd.
 2014-08 PHASE3
NCT01886560 UNKNOWN
Eye Burns
Sun Yat-sen University
 2013-09 PHASE2; PHASE3
NCT01788215 COMPLETED
Polycystic Ovarian Syndrome (PCOS); Irregular Menstrual Cycles; Androgen Excess
University of Rochester
 2010-11 PHASE3
NCT01653522 WITHDRAWN
Migraine Disorders; Headache, Migraine; Migraine; Migraine Headache; Migraine With Aura; Migraine Without Aura; Headache Disorders, Primary
The Cleveland Clinic
 2012-07
NCT01885910 COMPLETED
Acne Vulgaris
Derm Research, PLLC
 2013-07 PHASE4
NCT03727620 COMPLETED
Aggressive Periodontitis
Mohammed V Souissi University
 2014-01-06 PHASE1; PHASE2
NCT01935622 TERMINATED
Non-ischemic Cardiomyopathy; Systolic Heart Failure (NYHA II-III)
Virginia Commonwealth University
 2012-07 PHASE2
NCT01825408 COMPLETED
Sinusitis
University of North Carolina, Chapel Hill
 2013-02 PHASE4
NCT00980148 COMPLETED
Chlamydial Infection
National Institute of Allergy and Infectious Diseases (NIAID)
 2009-12-02 PHASE3
NCT01867294 COMPLETED
Advanced Malignant Neoplasm; Dermatologic Complication
Academic and Community Cancer Research United
 2012-08-31 PHASE2
NCT02884713 COMPLETED
GASTRITIS
King Faisal Specialist Hospital & Research Center
 2013-06
NCT02538224 COMPLETED
Chronic Periodontitis
Islamic Azad University, Sanandaj
 2013-07 PHASE2; PHASE3
NCT01368341 COMPLETED
Erythema Migrans; Erythema Chronicum Migrans; Borreliosis; Lyme Disease; Early Lyme Disease
Morten Lindbaek
 2011-06 PHASE4
NCT01727973 COMPLETED
Graves Ophthalmopathy; Graves Disease; Eye Diseases; Thyroid Diseases; Endocrine System Diseases; Eye Diseases, Hereditary; Hyperthyroidism; Autoimmune Diseases; Immune System Diseases
Sun Yat-sen University
 2012-10 PHASE1; PHASE2
NCT01207739 COMPLETED
Lyme Disease; Borrelia Infection
Radboud University Medical Center
 2010-09 PHASE4
NCT01547325 WITHDRAWN
Dehisced Surgical Wounds
NanoSHIFT LLC
 2012-05
NCT01783860 COMPLETED
Posterior Blepharitis
Tehran University of Medical Sciences
 2013-01 PHASE2
NCT01499225 COMPLETED
Chronic Periodontitis
Yuhan Corporation
 2011-12 PHASE2
NCT01474590 COMPLETED
Acne
Galderma R&D
 2011-11 PHASE3
NCT01243437 COMPLETED
Plague
Centers for Disease Control and Prevention
 2010-12 PHASE2
NCT01426269 COMPLETED
Rosacea
Galderma R&D
 2011-09 PHASE4
NCT01418742 TERMINATED
Colorectal Carcinoma
Gesellschaft fur Medizinische Innovation - Hamatologie und Onkologie mbH
 2011-08 PHASE2
NCT00989742 COMPLETED
Lymphangioleiomyomatosis; Tuberous Sclerosis
University of Nottingham
 2009-07 PHASE4
NCT01198509 COMPLETED
Rheumatoid Arthritis; Psoriatic Arthritis; Periodontal Disease
NYU Langone Health
 2010-01
NCT02257658 COMPLETED
Syphilis
Los Angeles LGBT Center
 2011-09
NCT01398072 UNKNOWN
Chronic Obstructive Pulmonary Disease (COPD).
University College, London
 2011-12 PHASE3
NCT01188954 WITHDRAWN
Seroma
Northwell Health
 2010-01
NCT01112059 COMPLETED
Cystic Fibrosis
University of Alabama at Birmingham
 2008-11
NCT01308619 COMPLETED
Rosacea
Galderma R&D
 2011-04 PHASE4
NCT00917553 COMPLETED
Diabetic Retinopathy
Thomas Gardner
 2009-07 PHASE2
NCT00511875 COMPLETED
Diabetic Retinopathy
Thomas Gardner
 2008-07 PHASE2
NCT01469585 COMPLETED
Breakthrough Bleeding
University of Hawaii
 2011-11
NCT01595594 COMPLETED
Periodontal Disease; Type 2 Diabetes
University of Sao Paulo
 2010-03 PHASE3
NCT01320033 COMPLETED
Acne Vulgaris
Galderma R&D
 2011-03-29 PHASE2
NCT01010295 COMPLETED
Non-Hodgkin Lymphoma
International Extranodal Lymphoma Study Group (IELSG)
 2006-09 PHASE2
NCT00358462 COMPLETED
Urethritis
University of Washington
 2007-01 PHASE3
NCT00353158 COMPLETED
Healthy Volunteers; Fungal Infections; Bacterial Infections
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
 2007-05-25 PHASE1
NCT02220751 COMPLETED
Periodontitis; Type 2 Diabetes Mellitus
University of Sao Paulo
 2009-03 PHASE3
NCT01301586 UNKNOWN
ACNE VULGARIS
Nexgen Dermatologics, Inc.
 2010-11 PHASE1; PHASE2
NCT02005653 COMPLETED
Filarial; Infestation
Indian Council of Medical Research
 2009-02 PHASE4
NCT00469261 COMPLETED
Myocardial Infarction; Left Ventricular Remodeling
Careggi Hospital
 2007-05 PHASE2
NCT01012726 TERMINATED
Crohn's Disease
Gerhard Rogler
 2009-11
NCT01087476 UNKNOWN
Mucositis
Metropolitan Autonomous University
 2010-05 PHASE2
NCT01375491 COMPLETED
Type 2 Diabetes; Obesity
University of California, San Diego
 2009-10 PHASE4
NCT01245946 COMPLETED
Acne
Pontificia Universidad Catolica de Chile
 2010-10 PHASE2
NCT01014260 WITHDRAWN
Cardiovascular Disease
Johns Hopkins University
 2010-09 PHASE4
NCT01030666 TERMINATED
Periodontitis
Peter Eickholz
 2007-04 PHASE4
NCT00783523 COMPLETED
Arteriovenous Malformations; Cavernous Angiomas; Brain Aneurysms
University of California, San Francisco
 2008-03 PHASE1
NCT00803452 COMPLETED
Blepharitis
University of Louisville
 2008-07 PHASE4
NCT01323101 COMPLETED
Cystic Fibrosis
University of Southern California
 2008-04 PHASE4
NCT00910715 COMPLETED
Erythema Chronicum Migrans
University Medical Centre Ljubljana
 2009-06
NCT00942006 UNKNOWN
Suspected Early Lyme Neuroborreliosis
University Medical Centre Ljubljana
 2009-07
NCT00952861 WITHDRAWN
Pulmonary Disease, Chronic Obstructive
Odense University Hospital
 2009-10 PHASE4
NCT01254799 COMPLETED
Uterine Hemorrhage
Omar Mamdouh Shaaban
 2008-01 PHASE3
NCT00764361 COMPLETED
Diabetic Foot Ulcer
NanoSHIFT LLC
 2009-01 PHASE2
NCT00531934 COMPLETED
Non-Small Cell Lung Cancer
Hoffmann-La Roche
 2007-10 PHASE2
NCT00439166 COMPLETED
Alzheimer's Disease
Hamilton Health Sciences Corporation
 2007-02 PHASE3
NCT02168374 COMPLETED
Dental Caries
Aline R F de Castilho
 2008-03 PHASE2
NCT00480532 COMPLETED
Contraceptives, Oral
Oregon Health and Science University
 2007-05
NCT01798225 COMPLETED
Periodontal Disease; Type 2 Diabetes Mellitus
Medical University of South Carolina
 2007-12 PHASE4
NCT00803842 WITHDRAWN
Non Small Cell Lung Cancer
Northwestern University
 2008-10
NCT00568711 COMPLETED
Scrub Typhus
Dong-Min Kim
 2006-09
NCT00639873 COMPLETED
Malaria
Medical University of Vienna
 2008-06
NCT00892281 COMPLETED
Rosacea
Galderma R&D
 2009-04 PHASE4
NCT00964834 TERMINATED
Anthrax
PharmAthene, Inc.
 2009-07 PHASE1
NCT00246324 COMPLETED
Multiple Sclerosis
Louisiana State University Health Sciences Center Shreveport
 2003-12 PHASE4
NCT00857038 UNKNOWN
Chronic Obstructive Pulmonary Disease; Inflammation; Pulmonary Emphysema
Medical Center Alkmaar
 2009-04 PHASE4
NCT00715858 UNKNOWN
Alzheimer's Disease
McMaster University
 2008-05 PHASE3
NCT00066066 COMPLETED
Periodontitis; Periodontal Diseases
The Forsyth Institute
 2003-07 PHASE2
NCT00560703 COMPLETED
Blepharitis; Meibomianitis; Dry Eye
Galderma R&D
 2007-11 PHASE2
NCT00322465 COMPLETED
Urethritis
National Institute of Allergy and Infectious Diseases (NIAID)
 2006-11-17 PHASE2
NCT00855595 COMPLETED
Papulopustular Rosacea
LEO Pharma
 2009-02 PHASE4
NCT00688064 COMPLETED
Severe Acne Vulgaris
Galderma R&D
 2008-08 PHASE3
NCT00939562 COMPLETED
Bacterial Infection
Pfizer
 2008-11 PHASE4
NCT00355602 COMPLETED
Colitis, Ulcerative
University of Dundee
 2006-07
NCT00612573 COMPLETED
Acne Vulgaris
Warner Chilcott
 2008-02 PHASE2
NCT00830401 TERMINATED
Minor Intra-uterine Abnormalities
UMC Utrecht
 2007-06 PHASE2
NCT00243893 COMPLETED
Aneurysms; Arteriovenous Malformations
University of California, San Francisco
 2004-07 PHASE1
NCT00351273 COMPLETED
Arthritis, Reactive; Reiter Disease
University of South Florida
 2006-05 PHASE3
NCT00635609 COMPLETED
Acne Vulgaris
Warner Chilcott
 2008-03 PHASE4
NCT00170222 COMPLETED
Chronic Obstructive Pulmonary Disease
Medical Center Alkmaar
 2002-07 PHASE4
NCT00837213 COMPLETED
Acne
Stiefel, a GSK Company
 2007-08 PHASE4
NCT00246740 COMPLETED
Coronary Artery Bypass Grafting; Cardiopulmonary Bypass; Reperfusion Injury
University of Alberta
 2005-10 PHASE2
NCT00138801 COMPLETED
Lyme Neuroborreliosis
Sorlandet Hospital HF
 2004-03 PHASE3
NCT00547170 COMPLETED
Endometritis
University of Pittsburgh
 2007-01 PHASE4
NCT01205464 COMPLETED
Fatigue; Radicular Pain; Cognitive Dysfunction; Paresthesia; Paresis
Linkoeping University
 2005-02
NCT00419848 UNKNOWN
Acne
Shahid Beheshti University of Medical Sciences
 2006-08 PHASE2
NCT00495313 COMPLETED
Rosacea
CollaGenex Pharmaceuticals
 2007-03 PHASE4
NCT00376493 TERMINATED
Septic Abortion
Hospital de Clinicas de Porto Alegre
 2006-05 PHASE4
NCT00883818 COMPLETED
Overactive Bladder
Samsung Medical Center
 2007-01 PHASE4
NCT00353743 TERMINATED
Abortion, Septic
Hospital de Clinicas de Porto Alegre
 2006-05
NCT01518192 COMPLETED
Erythema Migrans; Post-Lyme Disease Symptoms
University Medical Centre Ljubljana
 2006-06 PHASE4
NCT00340691 COMPLETED
Mansonella Perstans Infection; Mp Microfilaremia
National Institute of Allergy and Infectious Diseases (NIAID)
 2004-12-06 PHASE2
NCT03584919 COMPLETED
Erythema Chronicum Migrans
University Medical Centre Ljubljana
 2006-06-01
NCT00031499 COMPLETED
Syphilis
National Institute of Allergy and Infectious Diseases (NIAID)
 2000-06 PHASE3
NCT00829764 COMPLETED
Healthy
Teva Pharmaceuticals USA
 2006-10 PHASE1
NCT00829790 COMPLETED
Healthy
Teva Pharmaceuticals USA
 2006-10 PHASE1
NCT00177333 COMPLETED
Abortion, Induced; Vomiting
University of Pittsburgh
 2005-09 PHASE4
NCT00647959 COMPLETED
Healthy
Mylan Pharmaceuticals Inc
 2006-03 PHASE1
NCT00351182 COMPLETED
Scrub Typhus
Dong-Min Kim
 2005-09 PHASE3
NCT00066027 COMPLETED
Periodontitis
University of Nebraska
 2002-06-01 PHASE3
NCT00648180 COMPLETED
Healthy
Mylan Pharmaceuticals Inc
 2005-07 PHASE1
NCT00649571 COMPLETED
Healthy
Mylan Pharmaceuticals Inc
 2005-07 PHASE1
NCT00775918 COMPLETED
Healthy
Ranbaxy Laboratories Limited
 2005-06
NCT00775177 COMPLETED
Healthy
Ranbaxy Laboratories Limited
 2005-06
NCT00016835 COMPLETED
Periodontal Disease; Diabetes Mellitus, Type 2
University of Michigan
 2001-10-17 PHASE2
NCT00652795 COMPLETED
To Determine Bioequivalence Under Fasting Conditions
Par Pharmaceutical, Inc.
 2004-07 PHASE1
NCT00002872 COMPLETED
Metastatic Cancer
Eastern Cooperative Oncology Group
 1997-01-10 PHASE3
NCT00001101 COMPLETED
Lyme Disease
National Institute of Allergy and Infectious Diseases (NIAID)
 PHASE3
NCT01380483 COMPLETED
To Determine Bioequivalence Under Fasting Conditions
Par Pharmaceutical, Inc.
 2000-01 PHASE1
NCT01380496 COMPLETED
To Determine Bioequivalence Under Fed Conditions
Par Pharmaceutical, Inc.
 1999-11 PHASE1
NCT00653380 COMPLETED
To Determine Bioequivalence Under Fasting Conditions
Par Pharmaceutical, Inc.
 1999-09 PHASE1
NCT00652704 COMPLETED
To Determine Bioequivalence Under Fed Conditions
Par Pharmaceutical, Inc.
 1999-07 PHASE1
NCT00012688 COMPLETED
Diabetes Mellitus; Poor Glycemic Control; Peridontal Disease
US Department of Veterans Affairs
NCT00439400 COMPLETED
Dry Eye
Alacrity Biosciences, Inc.
 2007-02 PHASE2
NCT00484250 COMPLETED
Oral Lichen Planus
Mashhad University of Medical Sciences
 2005-09 PHASE2
NCT00207584 COMPLETED
Mycoplasma Pneumoniae
Centers for Disease Control and Prevention
 1994-01
NCT00631501 UNKNOWN
Lateral Epicondylalgia (Tennis Elbow)
Kaunas University of Medicine
NCT00237016 COMPLETED
Relapsing Fever, Tick-borne; Jarisch Herxheimer Reaction
Medical Corps, Israel Defense Force
 2002-04 PHASE2; PHASE3
NCT00000938 COMPLETED
Lyme Disease
National Institute of Allergy and Infectious Diseases (NIAID)
 PHASE3
NCT00064766 UNKNOWN
Endometrial Bleeding; Periodontal Disease
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
 2003-02 PHASE4
NCT00428818 COMPLETED
Infection
University of Texas Southwestern Medical Center
 2005-08
NCT00538967 COMPLETED
Aortic Aneurysm, Abdominal
Leiden University Medical Center
 2002-05 PHASE2
NCT00355459 WITHDRAWN
Dry Eye Syndrome
University of Texas Southwestern Medical Center
 2005-08
NCT00007735 COMPLETED
Persian Gulf Syndrome; Mycoplasma Infections
US Department of Veterans Affairs
 1999-01 PHASE3
NCT00388778 UNKNOWN
Acne; Inflammation
Shahid Beheshti University of Medical Sciences
 2005-10 PHASE2; PHASE3
NCT00126204 COMPLETED
Aortic Aneurysm
The Foundation for Barnes-Jewish Hospital
 2004-03
NCT00041977 COMPLETED
Acne Rosacea
CollaGenex Pharmaceuticals
 2002-06 PHASE3
NCT00000403 COMPLETED
Osteoarthritis
Indiana University
 1996-09 PHASE3
NCT00126399 COMPLETED
Rosacea
CollaGenex Pharmaceuticals
 2004-06 PHASE3

(data from https://clinicaltrials.gov, updated on 2026-03-20)

Check the Doxycycline HCl product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Doxycycline HCl reversibly binds to the bacterial 30S ribosomal subunit and inhibits matrix metalloproteinases, thereby blocking aminoacyl-tRNA access to the mRNA-ribosome complex and preventing bacterial protein synthesis and tissue degradation. This dual antimicrobial and anti-inflammatory activity inhibits pathogen proliferation and extracellular matrix breakdown, providing the therapeutic rationale for its clinical evaluation in bacterial infections, inflammatory disorders, and ocular adnexal lymphomas.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

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Note: Technical data last updated: Sep 1, 2026.