CAS No. 10592-13-9
| IUPAC Name | (4S,4aR,5S,5aR,6R,12aR)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;hydrochloride | |
|---|---|---|
| CAS Number | 10592-13-9 | |
| Molecular Formula |
C22H24N2O8.HCl |
|
| Molecular Weight (MW) | 480.9 | |
| InChIKey | PTNZGHXUZDHMIQ-CVHRZJFOSA-N |
Doxycycline HCl is a broad-spectrum tetracycline antibiotic and matrix metalloproteinase (MMP) inhibitor that targets bacterial ribosomal machinery and mammalian MMPs. By reversibly binding to the bacterial 30S ribosomal subunit, it inhibits protein translation and bacterial cell proliferation. Additionally, it suppresses MMP-2 and MMP-9 expression and enzymatic activity, leading to attenuated cell migration, tissue remodeling, and inflammatory signaling pathways. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
96 mg/mL
(199.62 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
3 mg/mL
(6.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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