CAS No. 309-29-5
Batch:
Purity:99.73
Chemical Structure
Check the
Doxapram
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-ethyl-4-(2-morpholin-4-ylethyl)-3,3-diphenylpyrrolidin-2-one | |
|---|---|---|
| CAS Number | 309-29-5 | |
| Molecular Formula |
C24H30N2O2 |
|
| Molecular Weight (MW) | 378.51 | |
| SMILES | CCN1CC(C(C1=O)(C2=CC=CC=C2)C3=CC=CC=C3)CCN4CCOCC4 | |
| InChIKey | XFDJYSQDBULQSI-UHFFFAOYSA-N |
Doxapram is a central respiratory stimulant that acts as a selective inhibitor of TASK-1 (EC50 = 410 nM), TASK-3 (EC50 = 37 μM), and TASK-1/TASK-3 heterodimeric channels (EC50 = 9 μM). Inhibition of these two-pore domain potassium channels suppresses background potassium conductance, inducing cell depolarization and triggering hyperventilation through activation of peripheral chemoreceptors and central respiratory networks. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
76 mg/mL
(200.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 76 mg/mL |
| Water | Insoluble |
| DMSO |
75 mg/mL
(198.14 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 75 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.